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| Scientists applied an oncogene-associated, multicolor reporter mouse model to the small intestine to show that oncogene-expressing mutant crypts altered the cellular organization of neighboring wild-type crypts, thereby driving accelerated clonal drift.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated how Apc-mutant cells gain a clonal advantage over wild-type counterparts to achieve fixation and found that Apc-mutant cells were enriched for transcripts that encoded several secreted WNT antagonists, with Notum being the most highly expressed.
[Nature] |
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| Investigators developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable human intestinal epithelial cells (hIECs) progenitors and a functional hIEC monolayer exhibiting intestinal molecular features, cell type diversity, and high activities of intestinal transporters and metabolic enzymes such as cytochrome P450 3A4.
[Science Advances] |
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| GUT-103, composed of 17 strains that synergistically provide protective and sustained engraftment in the IBD inflammatory environment, prevented and treated chronic immune-mediated colitis.
[Nature Communications] |
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| Using the small intestinal crypt as a model, Optical Stem Cell Activity Reporter (OSCAR) revealed in real time the dynamics of dormancy induction and cellular differentiation in vitro, and allowed for the identification and isolation of several populations of transcriptionally diverse OSCARhigh and OSCARlow intestinal epithelial cell states in vivo.
[Nature Communications] |
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| Researchers examined the function of the RNF20/RNF40/H2Bub1 axis in intestinal inflammation in IBD patients and mouse models. They analyzed underlying molecular pathways in isolated primary intestinal epithelial cells and confirmed their findings in IBD resection specimens.
[Cell Death & Differentiation] |
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| Cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficiency led to intestinal stem cell loss and compromised intestinal barrier integrity upon dextran sodium sulfate-induced acute injury.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.
[Cell Death & Disease] |
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| Investigators showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells, suggesting that exosomal miR-21-5p was involved in angiogenesis and vascular permeability in CRC.
[Cell Death & Disease] |
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| Scientists examined the relationship of RAB11A to epithelial junctional complexes, Yes-Associated Protein (YAP), and the associated consequences on colonic epithelial tissue repair.
[Journal of Biological Chemistry] |
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| Researchers demonstrated that Claudin-2 was functionally required for colorectal cancer liver metastasis and that Claudin-2 expression in primary colorectal cancers was associated with poor overall and liver metastasis-free survival.
[Communications Biology] |
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| The authors showed that H. pylori increased the proliferation, growth, migration, and invasiveness of gastric cancer cells via its effects on semaphorin 5A and that H. pylori increased the expression of matrix metalloproteinase 9 (MMP9) in gastric cancer cells via the semaphorin 5A-mediated extracellular regulated protein kinase (ERK) signaling pathway.
[Molecular Therapy-Oncolytics] |
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| Scientists review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1α.
[Mucosal Immunology] |
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| The authors review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages.
[Current Opinion in Genetics & Development] |
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| Following successful research that showed how a drug available on the NHS could boost fitness of healthy stem cells in the gut, a clinical trial funded by the Dutch Cancer Society testing the effect of lithium of bowel cancer development in individuals with familial adenomatous polyposis will be performed in the Netherlands.
[Worldwide Cancer Research (EurekAlert!)] |
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| September 13 – 15, 2021
Virtual |
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| | Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States |
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| | University of Maryland – College Park, Maryland, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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