 | | Vol. 7.21 – 11 June, 2021 |
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| The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the intestine-enriched miR-802 was a central regulator of intestinal epithelial cell proliferation, Paneth cell function, and enterocyte differentiation.
[Nature Communications] |
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| By targeting antiapoptotic proteins with specific BH3 mimetics in organoid models of colorectal cancer progression, scientists found that BCL-2 was essential only during instestinal stem cell transformation while MCL1 inhibition did not affect adenoma outgrowth.
[Cell Death & Differentiation] |
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| Researchers demonstrated that αSMA+ cancer-associated fibroblast in colorectal cancer (CRC) exerted tumor-restraining functions via BMP4/TGFβ1 paracrine signaling that served to suppress Lgr5+ CSCs and promoted anti-tumor immunity, ultimately limiting CRC progression.
[Oncogene] |
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| In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
[eLife] |
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| The authors linked intestinal dysbiosis, systemic inflammation, and inflammasome activity to intestinal epithelial cells major histocompatibility complex class II upregulation via an intestinal serum Interleukin-18-interferon gamma axis.
[Mucosal Immunology] |
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| Researchers demonstrated that Zic2 was highly expressed in colon cancer tissues and correlated with poor survival. Knockdown of Zic2 inhibited colon cancer cell growth, arrested the cell cycle transition from G0/G1 to S phase, and suppressed tumor sphere formation in vitro.
[Cell Death & Disease] |
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| Scientists investigated the mechanisms of action of long non-coding RNA Bmp1 on damaged intestinal mucosa. They found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury.
[Cell Death & Disease] |
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| Investigators generated CYP3A4-expressing Caco-2 cells and attempted to establish a model that could simultaneously evaluate drug absorption and metabolism.
[Scientific Reports] |
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| Researchers investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
[Scientific Reports] |
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| This microscopic colitis review discusses the understanding of the immune response, genetics and the microbiome in disease pathogenesis along with progress in disease management through robust clinical trials.
[Nature Reviews Disease Primers] |
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| The authors review recent advances in the co-culture of microbes with intestinal and colonic epithelia, comparing the rapidly developing fields of organoids and organs-on-chips with other standard models.
[Cell Host & Microbe] |
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| Investigators summarize the existing research on polyamine metabolism and function, specifically the role of polyamines in gastric immune cell and epithelial cell function.
[Oncogene] |
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| BeiGene, Ltd. announced that the Center for Drug Evaluation of the China National Medical Products Administration has accepted a supplemental Biologics License Application for anti-PD-1 antibody tislelizumab for the treatment of patients with previously treated, locally advanced unresectable or metastatic microsatellite instability-high or mismatch repair-deficient solid tumors.
[BeiGene, Ltd.] |
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| July 8 – 10, 2021
Boston, Massachusetts, United States |
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| | City of Hope – Monrovia, California, United States |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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