 | | Vol. 7.22 – 18 June, 2021 |
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| Researchers demonstrated that the hypoxic microenvironment in primary colorectal cancer lesions boosted exosome release and selectively initiated a favorable pre-metastatic niche formation in the hepar, but not in other organs.
[Hepatology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that externalized phosphatidylserine (PS) was observed on the surface of colonic capillaries. Annexin A5 with high affinity for PS had a good targeting to the colon and effectively alleviated experimental colitis.
[Signal Transduction and Targeted Therapy] |
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| The authors demonstrated that IL-6 activated autophagy through the IL-6/JAK2/BECN1 pathway and promoted chemotherapy resistance in colorectal cancer.
[Nature Communications] |
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| Scientists identified autophagy-related protein 9B (ATG9B) as a key potential target gene for colorectal cancer (CRC) metastasis and found that ATG9B promoted CRC invasion mainly through autophagy-independent manner.
[Cell Death & Differentiation] |
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| Researchers determined that 14-3-3σ expression was significantly downregulated in primary human colorectal cancer when compared with adjacent normal colonic tissue in patient samples. Downregulation of 14-3-3σ in primary colorectal cancers was significantly associated with p53 mutation, increasing tumor stage, distant metastasis, and poor patient survival.
[Cancer Research] |
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| Investigators showed that the pyroptosis-inducing fragment GSDME N-terminal was detected in the inflamed colonic mucosa but not in the uninflamed mucosa of patients with Crohn’s disease (CD), suggesting that GSDME-mediated pyroptosis may be correlated with intestinal mucosal inflammation in CD.
[Cell Reports] |
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| The authors reported that asporin (ASPN) was upregulated in different stages of gastric cancer (GC), and associated with a poor prognosis, and found that ASPN markedly inhibited GC cell apoptosis and promoted cell growth in vitro and in vivo.
[Oncogene] |
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| Researchers showed the differentially expressed miRNAs in oxaliplatin-sensitive and oxaliplatin-resistant colorectal cancer cells through miRNA microarray technology and found that miR-135b-5p was significantly increased in oxaliplatin-resistant cells.
[Oncogene] |
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| Scientists developed an impedance system to measure the change in electrical resistance of 3D human pluripotent stem cell-derived intestinal organoids depending on the integrity of the intestinal epithelial cell membrane, which could reflect functionality and maturity.
[Analytical Chemistry] |
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| Neutrophil extracellular traps treatment induced intestinal epithelial monolayer barrier disruption and endoplasmic reticulum (ER) stress activation in a dose-dependent manner in vitro, and ER stress inhibition markedly attenuated intestinal apoptosis and tight junction injury.
[Cell Death & Disease] |
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| The authors investigated the mechanisms by which PRDX2 promoted the proliferation of colorectal cancer, and found that the oncogenic property of PRDX2 may have been attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation.
[Cell Death & Disease] |
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| Researchers employed a doxycycline-inducible phosphatase of regenerating liver-3 (PRL-3) mouse strain to show that aberrant PRL-3 expression within a non-cancerous background led to the death of Lgr5+ intestinal stem cells and to Paneth cell expansion.
[Journal of Molecular Medicine] |
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| The impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. Alginate and chitosan were used to coat the nanoparticles and provide negative and positive charges on the particles, respectively.
[Marine Drugs] |
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| The authors discuss the biology of gastroesophageal stem cells and their role as cells of origin in cancer, and summarize the interactions between the stromal niche and gastroesophageal stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during carcinogenesis.
[Cell Stem Cell] |
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| Scientists provide highlights on the development of organoid technology, and the use of this culture system to study the pathophysiology of specific mutations in the development of pancreatic and gastric cancer.
[American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Progenity, Inc. announced the formation of its Inflammatory Bowel Disease Clinical Advisory Board. The advisory board includes respected researchers and clinicians who are thought leaders in the research and treatment of inflammatory bowel disease.
[Progenity, Inc. (Globe Newswire, Inc.)] |
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| Turning Point Therapeutics, Inc. announced that TPX-0022, the company’s inhibitor of MET and the associated cancer signaling pathways of SRC and CSF1R, has been granted orphan drug designation by the FDA for the treatment of patients with gastric cancer, including gastroesophageal junction adenocarcinoma.
[Turning Point Therapeutics, Inc.] |
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| September 28 -30, 2021
Virtual |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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| | City of Hope – Monrovia, California, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of Maryland, College Park – College Park, Maryland, United States |
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| | BioMed X Institute – Heidelberg, Germany |
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