 | | Vol. 7.27 – 23 July, 2021 |
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| Cancer-associated fibroblast-activated stromal signaling, interleukin-6/8-JAK2, induced BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, resulting in BRD4 stabilization due to interaction with the deubiquitinase UCHL3.
[Nature Communications] |
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| | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified that Forkhead box protein O1 (Foxo1) regulates mucus secretion by goblet cells and determines intestinal homeostasis. Loss of Foxo1 in intestinal epithelial cells resulted in defects in goblet cell autophagy and mucus secretion, leading to an impaired gut microenvironment and dysbiosis.
[Journal of Experimental Medicine] |
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| Researchers found that 5-hydroxytryptamine (5-HT) levels, as well as expression of tryptophan hydroxylase 1 were significantly upregulated in colorectal tumor tissues from colorectal cancer (CRC) patients, CRC mouse models, and CRC cell lines, when compared with normal colorectal tissues or epithelial cell lines.
[Cancer Immunology Research] |
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| The authors screened a library of non-characterized small molecules against a heterogeneous collection of patient-derived colorectal cancer (CRC) spheroids. Knockout of cyclin K (CCNK) or CDK12 decreased proliferation of CRC cells in vitro and tumor growth in vivo.
[Cell Reports] |
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| Scientists used patient derived organoids to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease with varying phenotypes to screen for disease profiles and potential druggable targets.
[Cellular and Molecular Gastroenterology and Hepatology] |
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| Researchers investigated the regulation of intestinal heat shock protein70 by propionate in human intestinal Caco-2 cells and the colon of fermentable dietary fiber-fed mice and germ-free mice.
[Journal of Agricultural and Food Chemistry] |
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| The effects of 2′-FL, 3-FL, DP3–DP10, DP10–DP60 and DP30–DP60 inulins and DM7, DM55 and DM69 pectins were studied on pathogen adhesion to Caco-2 cells.
[Food & Function] |
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| The authors investigated the effect of deleted in malignant brain tumors 1 (DMBT1) on doxorubicin-induced mucositis. Intestinal tissue was analyzed for the expression of DMBT1 and proinflammatory cytokines.
[Scientific Reports] |
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| The intestinal permeability of metal(loid)s such as arsenic, cadmium, lead and mercury was examined, as influenced by gut microbes and chelating agents using an in vitro gastrointestinal/Caco-2 cell intestinal epithelium model.
[Scientific Reports] |
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| NOX5 knockdown significantly inhibited cell migration and invasion in both HCT116 and SW48 cells; however, NOX5 knockdown reduced cell proliferation in only HCT116 cells.
[International Journal of Oncology] |
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| Investigators studied the inhibitory effect of IRAK1 and IRAK4 as a preventive strategy using a colitis-induced tumorigenesis mouse model. IRAK1/4 inhibitor treatment attenuated colitis-induced tumorigenesis by inhibiting epithelial–mesenchymal transition.
[Journal of Biochemical and Molecular Toxicology] |
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| The authors explain how different metabolites of tryptophan are involved in the pathophysiology of IBD and colorectal cancer, as a major complication of IBD.
[International Reviews of Immunology] |
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| Scientists focus on advanced regenerative-based methods including stem cell therapy, exosome therapy, and tissue engineering used in the treatment of perianal fistula.
[Inflammatory Bowel Diseases] |
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| Novigenix SA announced that it has been awarded the 2021 Felix Burda Award in the Medicine & Science category. The Felix Burda Award was created by the Felix Burda Foundation to honor individuals and teams having made outstanding contributions to the prevention and early detection of colorectal cancer.
[Novigenix SA] |
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| September 21 – 24, 2021
Virtual |
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| | Stanford University – Palo Alto, California, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | Tübingen University – Tuebingen, Germany |
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| | Research Center for Molecular Medicine – Vienna, Austria |
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| | The Hebrew University of Jerusalem – Jerusalem, Israel |
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