| Vol. 7.29 – 6 August, 2021 |
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| Scientists advanced a concept that several Enterobacteriaceae, including patient-derived clinical isolates, had an efficient growth strategy to exploit soluble factors that were released from dying gut epithelial cells. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers provided a comprehensive single-cell atlas of the developing mouse colon and evidence for the reactivation of embryonic genes in disease. [Cell Reports] |
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| Investigators generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells. [Oncogene] |
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| The authors examined the expression of RNF141 in 64 pairs of colorectal cancer and adjacent normal tissues by real-time PCR, Western blot, and immunohistochemical analysis. [Oncogene] |
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| Scientists demonstrated that oxaliplatin-resistant colorectal cancer cells were sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had minimal effects on TRAIL sensitivity following CRISPR-Cas9 deletion of caspase-10 in parental cells. [eLife] |
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| Researchers investigated the role of the protein kinase A regulatory subunit PRKAR2A in colitis and observed that PRKAR2A deficiency protected mice from dextran sulfate sodium-induced experimental colitis and that the intestinal epithelial cell-specific deletion of Prkar2a contributed to this protection. [Mucosal Immunology] |
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| The expression levels and prognostic value of circEVI5 were validated in gastric cancer (GC) tissue samples by using qRT-PCR. circEVI5 was significantly downregulated in GC tissues and cells, and low circEVI5 expression was correlated with poor prognosis. [Cell Death & Disease] |
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| The authors showed that C. jejuni released a potent pro-inflammatory compound into its environment, which activated an NF-κB-mediated pro-inflammatory response including the induction of CXCL8, CXCL2, TNFAIP2 and PTGS2. [PLoS Pathogens] |
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| Investigators profiled a panel of 39 genes potentially involved in cancer predisposition and searched for germline variants in IBD patients with colorectal cancer or high-grade dysplasia. [Inflammatory Bowel Diseases] |
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| Scientists studied the interaction of murine macrophages and intestinal epithelial cells with well-characterized poly(styrene) microplastic particles (MPP) of varying sizes and found that the epithelial cells did not ingest MPP in significant numbers. [Scientific Reports] |
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| Loss of Cdx function led to a rapid and pronounced attenuation of H2-T3, followed by a decrease in iCD8α cell number, an increase in macrophage infiltration and activation of pro-inflammatory cascades, suggesting a previously unrecognized role for Cdx in intestinal homeostasis through H2-T3-dependent regulation of iCD8α cells. [Scientific Reports] |
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| Researchers explored the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice and showed that Dioscin reduced DSS-induced disease activity index increase, colon length shortening, and colon pathological damage. [International Immunopharmacology] |
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| The anticancer activity of C. gigantea stem bark extract, both alone and in combination with 5-fluorouracil, was evaluated. [PLoS One] |
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| Investigators provide an overview of estrogen and its receptors, particularly ERβ, in the pathophysiology of IBDs. [Essays in Biochemistry] |
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| The authors provide an overview of the alternative splicing (AS) events related to colorectal cancer, focusing on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. [Cell Death & Disease] |
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| Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders. [Beyond Celiac] |
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| September 22 – 25, 2021 Virtual |
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| Philipps University of Marburg – Marburg, Germany |
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| Harvard Medical School​ – Boston, Massachusetts, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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