Intestinal Cell News Volume 7.29 | Aug 6 2021

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    2021-08-06 | ICN 7.29


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.29 – 6 August, 2021
    TOP STORY

    Microbes Exploit Death-Induced Nutrient Release by Gut Epithelial Cells

    Scientists advanced a concept that several Enterobacteriaceae, including patient-derived clinical isolates, had an efficient growth strategy to exploit soluble factors that were released from dying gut epithelial cells.
    [Nature]

    Abstract

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    Tracing Colonic Embryonic Transcriptional Profiles and Their Reactivation upon Intestinal Damage

    Researchers provided a comprehensive single-cell atlas of the developing mouse colon and evidence for the reactivation of embryonic genes in disease.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Blockade of CHRNB2 Signaling with a Therapeutic Monoclonal Antibody Attenuates the Aggressiveness of Gastric Cancer Cells

    Investigators generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells.
    [Oncogene]

    Abstract

    RNF141 Interacts with KRAS to Promote Colorectal Cancer Progression

    The authors examined the expression of RNF141 in 64 pairs of colorectal cancer and adjacent normal tissues by real-time PCR, Western blot, and immunohistochemical analysis.
    [Oncogene]

    Full Article

    Oxaliplatin Resistance in Colorectal Cancer Enhances TRAIL Sensitivity via Death Receptor 4 Upregulation and Lipid Raft Localization

    Scientists demonstrated that oxaliplatin-resistant colorectal cancer cells were sensitized to TRAIL-mediated apoptosis. Oxaliplatin-resistant cells exhibited transcriptional downregulation of caspase-10, but this had minimal effects on TRAIL sensitivity following CRISPR-Cas9 deletion of caspase-10 in parental cells.
    [eLife]

    Full Article

    PRKAR2A Deficiency Protects Mice from Experimental Colitis by Increasing IFN-Stimulated Gene Expression and Modulating the Intestinal Microbiota

    Researchers investigated the role of the protein kinase A regulatory subunit PRKAR2A in colitis and observed that PRKAR2A deficiency protected mice from dextran sulfate sodium-induced experimental colitis and that the intestinal epithelial cell-specific deletion of Prkar2a contributed to this protection.
    [Mucosal Immunology]

    Full Article

    circEVI5 Acts as a miR-4793-3p Sponge to Suppress the Proliferation of Gastric Cancer

    The expression levels and prognostic value of circEVI5 were validated in gastric cancer (GC) tissue samples by using qRT-PCR. circEVI5 was significantly downregulated in GC tissues and cells, and low circEVI5 expression was correlated with poor prognosis.
    [Cell Death & Disease]

    Full Article

    The ALPK1 Pathway Drives the Inflammatory Response to Campylobacter jejuni in Human Intestinal Epithelial Cells

    The authors showed that C. jejuni released a potent pro-inflammatory compound into its environment, which activated an NF-κB-mediated pro-inflammatory response including the induction of CXCL8, CXCL2, TNFAIP2 and PTGS2.
    [PLoS Pathogens]

    Full Article

    Germline Alterations in Patients with IBD-Associated Colorectal Cancer

    Investigators profiled a panel of 39 genes potentially involved in cancer predisposition and searched for germline variants in IBD patients with colorectal cancer or high-grade dysplasia.
    [Inflammatory Bowel Diseases]

    Abstract

    Noxic Effects of Polystyrene Microparticles on Murine Macrophages and Epithelial Cells

    Scientists studied the interaction of murine macrophages and intestinal epithelial cells with well-characterized poly(styrene) microplastic particles (MPP) of varying sizes and found that the epithelial cells did not ingest MPP in significant numbers.
    [Scientific Reports]

    Full Article

    Cdx2 Regulates Immune Cell Infiltration in the Intestine

    Loss of Cdx function led to a rapid and pronounced attenuation of H2-T3, followed by a decrease in iCD8α cell number, an increase in macrophage infiltration and activation of pro-inflammatory cascades, suggesting a previously unrecognized role for Cdx in intestinal homeostasis through H2-T3-dependent regulation of iCD8α cells.
    [Scientific Reports]

    Full Article

    Dioscin Prevents DSS-Induced Colitis in Mice with Enhancing Intestinal Barrier Function and Reducing Colon Inflammation

    Researchers explored the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice and showed that Dioscin reduced DSS-induced disease activity index increase, colon length shortening, and colon pathological damage.
    [International Immunopharmacology]

    Abstract

    Calotropis gigantea Stem Bark Extract Induced Apoptosis Related to ROS and ATP Production in Colon Cancer Cells

    The anticancer activity of C. gigantea stem bark extract, both alone and in combination with 5-fluorouracil, was evaluated.
    [PLoS One]

    Full Article

    Webinar: The Promise of Organoid Medicine
    REVIEWS

    Estrogen Receptor Actions in Colitis

    Investigators provide an overview of estrogen and its receptors, particularly ERβ, in the pathophysiology of IBDs.
    [Essays in Biochemistry]

    Abstract

    Alternative Splicing of mRNA in Colorectal Cancer: New Strategies for Tumor Diagnosis and Treatment

    The authors provide an overview of the alternative splicing (AS) events related to colorectal cancer, focusing on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    Beyond Celiac Partners with University of Sheffield, UK, to Research Neuropathology of Celiac Disease and Gluten-Related Disorders

    Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders.
    [Beyond Celiac]

    Press Release

    FEATURED EVENT

    CRISPR and Beyond: Perturbations at Scale to Understand Genomes

    September 22 – 25, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Stem Cell Biology in Intestinal Tumorigenesis

    Philipps University of Marburg – Marburg, Germany

    Postdoctoral Research Fellow – Inflammatory Bowel Disease

    Harvard Medical School​ – Boston, Massachusetts, United States

    Manager – Organoid Core Facility

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Fellow – Cancer Genomics and Liquid Biopsies

    University of Gothenburg – Gothenburg, Sweden

    Postdoctoral Research Fellow – Human Gastrointestinal Organoids

    Cincinnati Children’s Hospital – Cincinnati, Ohio, United States

    > See All Jobs

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