 | | Vol. 7.32 – 27 August, 2021 |
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| Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.
[Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers indicated that intraepithelial CD8+ T cells were activated upon infection of intestinal epithelial cells with SARS-CoV-2, providing one possible explanation for gastrointestinal symptoms associated with COVID-19.
[Mucosal Immunology] |
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| Flow cytometric, ultrastructural and transcriptional profiling showed that αEβ7-expressing antibody-secreting cells represented an undescribed subset of terminally-differentiated intestinal plasma cells that established direct cell to cell contact with intestinal epithelium.
[Mucosal Immunology] |
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| Scientists investigated the role of circular RNA (circRNAs) which shared the same pre-mRNA with Sp1 transcription factor (SP1) in colorectal cancer (CRC) cells and identified that hsa_circ_0026628, a circRNA that originated from SP1 pre-mRNA, was upregulated in CRC cells.
[Cell Death & Disease] |
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| Investigators investigated donor-to-donor variability in human gut adult stem cell organoids. They examined intestinal developmental pathways during culture differentiation in ileum- and colon-derived cultures established from multiple donors, showing that differentiation patterns were consistent among cultures.
[Stem Cell Reports] |
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| The authors investigated the effect of trastuzumab deruxtecan on the expression of HLA class I and CXCL9/10/11, T cell chemoattractants, in HER2-positive human gastric cancer cells.
[Scientific Reports] |
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| Scientists analyzed cell-free DNA originating from nucleus and mitochondria and investigated their characteristics and mutation status in a cohort of 18 colorectal cancer patients and ten healthy controls using targeted next-generation sequencing and digital PCR.
[Scientific Reports] |
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| The authors investigated the protein profile of porcine rotavirus (PoRV)-infected IPEC-J2 cells using quantitative proteomics and provided valuable information to better understand the mechanisms underlying the host responses to PoRV infection in piglets.
[Journal of Proteomics] |
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| Scientists investigated the effect of diclofenac, a selective COX-2 inhibitor, on cell adhesion molecules and apoptosis in human colon adenocarcinoma cells. Levels of homing cell adhesion molecule, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and epithelial cell adhesion molecule were evaluated in cancer cells overexpressing or not expressing COX-2.
[Naunyn-Schmiedebergs Archives of Pharmacology] |
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| Focusing on peptides as examples of a macromolecule class, investigators review physiological impediments to optimal luminal presentation, discuss the efficacy of current permeation enhancers-based oral dosage forms, and suggest strategies that might be used to improve them.
[Advanced Drug Delivery Reviews] |
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| Merck, Inc. announced that KEYTRUDA, Merck’s anti-PD-1 therapy, has received two new approvals from the Japan Pharmaceuticals and Medical Devices Agency.
[Merck & Co. Inc.] |
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| November 17 – 19, 2021
Virtual |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | Amgen – San Francisco, California, United States |
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| | Philipps University of Marburg – Marburg, Germany |
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