Intestinal Cell News Volume 7.33 | Sep 03 2021

    By
    Justin.choi
    -
    0
    39







    2021-09-03 | ICN 7.33


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.33 – 3 September, 2021
    TOP STORY

    Chronic Toxoplasma gondii Infection Enhances Susceptibility to Colitis

    Scientists examined the effect of the chemical irritant dextran sodium sulfate on intestinal damage and wound healing in chronically infected mice.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Learn more about cGMP-manufactured StemSpan™-ACF Without Phenol Red for culturing hematopoietic cell therapy products
    PUBLICATIONSRanked by the impact factor of the journal

    Expansion of Monocytic Myeloid-Derived Suppressor Cells Ameliorated Intestinal Inflammatory Response by Radiation through SOCS3 Expression

    Scientists demonstrated that radiation exposure in mice promoted the expansion of splenic and intestinal myeloid-derived suppressor cells and caused intestinal inflammation due to the increased secretion of cytokines.
    [Cell Death & Disease]

    Abstract

    Engineered Exosomes for Co-delivery of PGM5-AS1 and Oxaliplatin to Reverse Drug Resistance in Colon Cancer

    Scientists showed that the low expression of PGM5 antisense RNA 1 in colon cancer was induced by transcription inhibitor, GFI1B. PGM5-AS1 prevented proliferation, migration, and acquired oxaliplatin tolerance of colon cancer cells.
    [Journal of Cellular Physiology]

    Abstract

    CDKN2B Antisense RNA 1 Suppresses Tumor Growth in Human Colorectal Cancer by Targeting MAPK Inactivator Dual Specificity Phosphatase 1

    Researchers investigated the role of CDKN2B-AS1 and the underlying mechanism in human colorectal cancer. Gain- and loss-of-function assays were performed to explore the role of CDKN2B-AS1 in the malignant behavior of HCT116 and SW480 CRC cells in vitro and in vivo.
    [Carcinogenesis]

    Abstract

    STING-Mediated Syk Signaling Attenuates Tumorigenesis of Colitis-Associated Colorectal Cancer through Enhancing Intestinal Epithelium Pyroptosis

    To investigate the role of STING-modulated pyroptosis in the development of colitis-associated colorectal cancer (CAC), STING knockout and wild type mice were challenged with azoxymethane and dextran sodium sulfate to establish a murine CAC model.
    [Inflammatory Bowel Diseases]

    Abstract

    Protective Mechanism of Rice-Derived Lipids and Glucosylceramide in an In Vitro Intestinal Tract Model

    Scientists investigated the effects of rice lipid fractions and sphingolipid glucosylceramide (GlcCer) on differentiated Caco-2 cells treated with lipopolysaccharide (LPS), in particular, they evaluated the mechanism of action of GlcCer using related substances and metabolic enzyme inhibitors.
    [Journal of Agricultural and Food Chemistry]

    AbstractGraphical Abstract

    Sphingomyelin Nanosystems Loaded with Uroguanylin and Etoposide for Treating Metastatic Colorectal Cancer

    Investigators proposed the chemical modification of uroguanylin, a natural ligand for the Guanylyl Cyclase receptor, expressed in metastatic colorectal cancer tumors, to favor its anchoring to sphingomyelin nanosystems.
    [Scientific Reports]

    Full Article

    Comprehensive Polar Metabolomics and Lipidomics Profiling Discriminates the Transformed from the Non-Transformed State in Colon Tissue and Cell Lines

    Researchers performed untargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry-based polar metabolomics and lipidomics to non-transformed and transformed colon cell lines as well as tissue samples from ten colorectal cancer patients.
    [Scientific Reports]

    Full Article

    Alantolactone Exhibits Antiproliferative and Apoptosis-Promoting Properties in Colon Cancer Model via Activation of the MAPK-JNK/C-Jun Signaling Pathway

    The authors performed a study to explore the effect and mechanism of Alantolactone (ATL) on colorectal cancer. The CCK-8 assay, colony formation assay, Wound-healing and Transwell assays were performed to evaluate the cytotoxic effect, antiproliferative effect, anti-migratory and anti-invasive properties of ATL respectively.
    [Molecular and Cellular Biology]

    Abstract

    Deoxycholic Acid Delays the Wound Healing of Colonic Epithelial Cells via Transmembrane G-Protein-Coupled Receptor 5

    Researchers investigated the role of transmembrane G-protein-coupled receptor in wound healing in the context of colonic epithelial cells in the presence of bile acids.
    [Journal of Gastroenterology and Hepatology]

    Abstract

    Explore scientific events this September with the Science Events Calendar.
    REVIEWS

    Enteric Neuroimmune Interactions Coordinate Intestinal Responses in Health and Disease

    The authors discuss how the enteric nervous system can regulate and be regulated by immune responses and how such interactions control whole tissue physiology.
    [Mucosal Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Yemoja Joins MIGAL Institute to Pioneer Major Study of Microalgae for Inflammatory Bowel Disease

    Microalgae cultivation start-up Yemoja Ltd. is joining the MIGAL Galilee Research institute to spearhead an extensive, four-year research initiative to identify algae-sourced compounds with the potential to help manage inflammation and Inflammatory Bowel Disease.
    [Yemoja, Ltd. (BioSpace, Inc.)]

    Press Release

    FEATURED EVENT

    Intestinal Stem Cell – Niche Interactions in Health and Disease Conference

    May 22 – 25, 2022
    Cancun, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – GI Research Institute

    GI Research Institute – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Immune Homeostasis of the Intestinal Tract

    University of North Dakota – Grand Forks, North Dakota, United States

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Investigator – Host Immunity and Microbiome

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Scientist – Autoimmune and Inflammatory Diseases

    Amgen – San Francisco, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by