| Vol. 7.35 – 17 September, 2021 |
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| Researchers showed that a high-fat diet reduced the expression of the major histocompatibility complex class II genes in intestinal epithelial cells, including intestinal stem cells. [Cell Stem Cell] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists uncovered a novel role of T cell–stem/transient amplifying cell contact in intestinal stem cell (ISC) fate decisions. They showed that intestinal lymphocyte depletion resulted in skewed ISC differentiation in mice, which could be rescued by T cell transfer. [Cell Research] |
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| The authors generated serine-threonine kinase receptor-associated protein (Strap) intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments. [Gastroenterology] |
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| Using a combination of in vitro and in vivo assays, scientists demonstrated that Tspan6 functioned as a tumor suppressor in colorectal cancer by attenuating the epidermal growth factor receptor–based signaling axis. [Proceedings of the National Academy of Sciences of the United States of America] |
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| TKT deficiency significantly accumulated pentose phosphate pathway metabolites and decreased glycolytic metabolites, thereby reducing ATP production, which resulted in excessive apoptosis and defective intestinal barrier. [Cell Death & Disease] |
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| Researchers developed a low-viscosity matrix suspension culture method that enabled efficient establishment and propagation of organoids and tumoroids from the human large intestine. [Communications Biology] |
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| Using quantitative real-time RT-PCR and western blot analysis, scientists analysed the changes in the expression of hyaluronan (HA)-synthesizing enzymes and HA-degrading enzymes in pancreatic ductal adenocarcinoma cell lines under hypoxic conditions. [Scientific Reports] |
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| The regulatory role of miR-19b in colorectal cancer stem cells and radiotherapy-resistant cells was determined using miRNA microarray analysis, and its prognostic value was probed using the TCGA database. [Kaohsiung Journal of Medical Sciences] |
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| The objective of the research work was to develop polyplexes for co-delivery of plasmid DNA with retinoic acid against colorectal cancer cell line (HCT-15). [Journal of Materials Science-Materials in Medicine] |
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| Atractylenolide III significantly inhibited the cell growth and induced cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro and regulated the Bax/Bcl-2 apoptotic signaling pathway through promoting the expression of proapoptotic related gene/proteins Bax, caspase-9 and caspase-3. [Anti-Cancer Drugs] |
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| The authors summarize the available data supporting the multiple effects of interleukin-34 in human colorectal carcinoma. [Cell Death Discovery] |
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| Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Opdivo in combination with fluoropyrimidine and platinum-containing chemotherapy for the first-line treatment of adult patients with HER2-negative advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma whose tumors express PD-L1 with a combined positive score greater than five. [Bristol Myers Squibb] |
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| October 19 – 20, 2021 Virtual |
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| Scripps Research Florida – Jupiter, Florida, United States |
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| Zhejiang University School of Medicine – Hangzhou, China |
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| Purdue University – West Lafayette, Indiana, United States |
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| National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| Amgen – San Francisco, California, United States |
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