Intestinal Cell News Volume 7.35 | Sep 17 2021

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    2021-09-17 | ICN 7.35


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.35 – 17 September, 2021
    TOP STORY

    Dietary Suppression of MHC Class II Expression in Intestinal Epithelial Cells Enhances Intestinal Tumorigenesis

    Researchers showed that a high-fat diet reduced the expression of the major histocompatibility complex class II genes in intestinal epithelial cells, including intestinal stem cells.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Tumors Are 3D. Shouldn't Your In Vitro Model Be? Learn More.
    PUBLICATIONSRanked by the impact factor of the journal

    Integrin αEβ7+ T Cells Direct Intestinal Stem Cell Fate Decisions via Adhesion Signaling

    Scientists uncovered a novel role of T cell–stem/transient amplifying cell contact in intestinal stem cell (ISC) fate decisions. They showed that intestinal lymphocyte depletion resulted in skewed ISC differentiation in mice, which could be rescued by T cell transfer.
    [Cell Research]

    Abstract

    STRAP is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis through a Feed-Forward Mechanism

    The authors generated serine-threonine kinase receptor-associated protein (Strap) intestinal epithelial knockout mice by crossing mice containing floxed alleles of Strap with Villin-Cre mice. They used human colon cancer cell lines and human and mouse colon tumor-derived organoids for STRAP knockdown/knockout and overexpression experiments.
    [Gastroenterology]

    Abstract

    Tetraspanin 6 Is a Regulator of Carcinogenesis in Colorectal Cancer

    Using a combination of in vitro and in vivo assays, scientists demonstrated that Tspan6 functioned as a tumor suppressor in colorectal cancer by attenuating the epidermal growth factor receptor–based signaling axis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    TKT Maintains Intestinal ATP Production and Inhibits Apoptosis-Induced Colitis

    TKT deficiency significantly accumulated pentose phosphate pathway metabolites and decreased glycolytic metabolites, thereby reducing ATP production, which resulted in excessive apoptosis and defective intestinal barrier.
    [Cell Death & Disease]

    Full Article

    Low-Viscosity Matrix Suspension Culture Enables Scalable Analysis of Patient-Derived Organoids and Tumoroids from the Large Intestine

    Researchers developed a low-viscosity matrix suspension culture method that enabled efficient establishment and propagation of organoids and tumoroids from the human large intestine.
    [Communications Biology]

    Full Article

    Hypoxia Increases KIAA1199/CEMIP Expression and Enhances Cell Migration in Pancreatic Cancer

    Using quantitative real-time RT-PCR and western blot analysis, scientists analysed the changes in the expression of hyaluronan (HA)-synthesizing enzymes and HA-degrading enzymes in pancreatic ductal adenocarcinoma cell lines under hypoxic conditions.
    [Scientific Reports]

    Full Article

    Exosomal MicroRNA-19b Targets FBXW7 to Promote Colorectal Cancer Stem Cell Stemness and Induce Resistance to Radiotherapy

    The regulatory role of miR-19b in colorectal cancer stem cells and radiotherapy-resistant cells was determined using miRNA microarray analysis, and its prognostic value was probed using the TCGA database.
    [Kaohsiung Journal of Medical Sciences]

    Full Article

    Polyplexes of Retinoic Acid: An In Vitro Study of Complex Nanostructures against Colorectal Cancer Cell Line (HCT-15)

    The objective of the research work was to develop polyplexes for co-delivery of plasmid DNA with retinoic acid against colorectal cancer cell line (HCT-15).
    [Journal of Materials Science-Materials in Medicine]

    AbstractGraphical Abstract

    Atractylenolide III Induces Apoptosis by Regulating the Bax/Bcl-2 Signaling Pathway in Human Colorectal Cancer HCT-116 Cells In Vitro and In Vivo

    Atractylenolide III significantly inhibited the cell growth and induced cellular apoptosis in HCT-116 cells in a concentration dependence manner in vitro and regulated the Bax/Bcl-2 apoptotic signaling pathway through promoting the expression of proapoptotic related gene/proteins Bax, caspase-9 and caspase-3.
    [Anti-Cancer Drugs]

    Abstract

    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    REVIEWS

    Interleukin-34 Promotes Tumorigenic Signals for Colon Cancer Cells

    The authors summarize the available data supporting the multiple effects of interleukin-34 in human colorectal carcinoma.
    [Cell Death Discovery]

    Full Article

    INDUSTRY AND POLICY NEWS

    Bristol Myers Squibb Receives Positive CHMP Opinion for Opdivo (Nivolumab) + Chemotherapy for Patients with HER2-Negative Advanced or Metastatic Gastric, Gastroesophageal Junction or Esophageal Adenocarcinoma Whose Tumors Express PD-L1 with CPS ≥ 5

    Bristol Myers Squibb announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended approval of Opdivo in combination with fluoropyrimidine and platinum-containing chemotherapy for the first-line treatment of adult patients with HER2-negative advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma whose tumors express PD-L1 with a combined positive score greater than five.
    [Bristol Myers Squibb]

    Press Release

    FEATURED EVENT

    The NYSCF Conference – New York Stem Cell Foundation

    October 19 – 20, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Mucosal Immunology

    Scripps Research Florida – Jupiter, Florida, United States

    Faculty – Urology, Clinical Pharmacy

    Zhejiang University School of Medicine – Hangzhou, China

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Investigator – Host Immunity and Microbiome

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    Scientist – Autoimmune and Inflammatory Diseases

    Amgen – San Francisco, California, United States

    > See All Jobs

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