Intestinal Cell News Volume 7.36 | Sep 24 2021

May 12, 2022

2021-09-24 | ICN 7.36

Intestinal Cell News by STEMCELL Technologies

Vol. 7.36 – 24 September, 2021

TOP STORY

Gut Epithelial IL-27 Confers Intestinal Immunity through the Induction of Intraepithelial Lymphocytes

Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 conferred barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.
[Journal of Experimental Medicine]

Abstract

Tools and products for your COVID-19 research.

PUBLICATIONSRanked by the impact factor of the journal

The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor–Dependent Metabolism in Myeloid Cells

The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Scientists showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

TNF-α Synergizes with IFN-γ to Induce Caspase-8-JAK1/2-STAT1-Dependent Death of Intestinal Epithelial Cells

Through unbiased kinome RNAi and drug repurposing screens, investigators identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.
[Cell Death & Disease]

Full Article

KLF5 Activates lncRNA DANCR and Inhibits Cancer Cell Autophagy Accelerating Gastric Cancer Progression

Researchers uncovered the oncogenic role of KLF5-dependent long non-coding RNA DANCR transcription in gastric cancer (GC) in vivo and in vitro, which implicated the miR-194/AKT2 axis in tumor growth regulation.
[NPJ Genomic Medicine]

Full Article

Thymus hirtus Sp. algeriensis Boiss. And Reut. Volatile Oil Enhances TRAIL/Apo2L Induced Apoptosis and Inhibits Colon Carcinogenesis through Upregulation of Death Receptor Pathway

The authors determined the anticancer activity of Thymus algeriensis and its underlying mechanisms using in vitro and in animal models.
[Aging-Us]

Full Article

E3 Ubiquitin Ligase SMURF2 Prevents Colorectal Cancer by Reducing the Stability of the YY1 Protein and Inhibiting the SENP1/C-Myc Axis

Scientists evaluated the effect of SMURF2 on the malignant phenotypes of colorectal cancer (CRC) cells and the underlying mechanism. The expression pattern of SMURF2 and YY1 in CRC clinical tissues and cells was characterized by immunohistochemistry and Western blot.
[Gene Therapy]

Abstract

Long Noncoding RNA DLGAP1-AS2 Facilitates Wnt1 Transcription through Physically Interacting with Six3 and Drives the Malignancy of Gastric Cancer

Findings demonstrated that DLGAP1-AS2 was significantly up-regulated in gastric cancer (GC) and its high expression was associated with poor prognosis, suggesting that DLGAP1-AS2 might be a putative oncogenic lncRNA of GC.
[Cell Death Discovery]

Full Article

Campylobacter concisus Upregulates PD-L1 mRNA Expression in IFN-γ Sensitized Intestinal Epithelial Cells and Induces Cell Death in Esophageal Epithelial Cells

Human intestinal epithelial HT-29 cells and esophageal epithelial FLO-1 cells with and without interferon (IFN)-γ sensitization were incubated with C. concisus strains. The level of programmed cell death ligand-1 (PD-L1) mRNA was quantified using quantitative real-time PCR.
[Journal of Oral Microbiology]

Full Article

Chlorothalonil Induces the Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell-Based In Vitro Monolayer Model by Activating MAPK Pathway

Scientists used Caco-2 cell monolayers as an in vitro model of human intestinal epithelial barrier (IEB) to evaluate the toxicity of chlorothalonil exposure on the structure and function of IEB.
[Acta Biochimica et Biophysica Sinica]

Abstract

Picropodophyllotoxin Induces G1/S Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway

The authors explored the anticancer activity and its underlying mechanisms of picropodophyllotoxin in HCT116 cells. The MTT assay was used to monitor the cell viability.
[World Journal of Microbiology & Biotechnology]

Abstract

Explore Antibodies for Epithelial Cell Markers

REVIEWS

Intestinal Interplay of Quorum Sensing Molecules and Human Receptors

The human gut is in permanent contact with microorganisms that play an important role in many physiological processes including metabolism and immunologic activity. These microorganisms communicate and manage themself by the quorum sensing system that helps to coordinate optimal growth and subsistence by activating signaling pathways that regulate bacterial gene expression.
[Biochimie]

Abstract

INDUSTRY AND POLICY NEWS

AbbVie Submits Regulatory Application to FDA for Risankizumab-Rzaa (SKYRIZI^®) for the Treatment of Patients 16 Years and Older with Moderate to Severe Crohn’s Disease

AbbVie announced that it has submitted an application to the US FDA seeking approval for risankizumab-rzaa, an interleukin-23 inhibitor, for the treatment of patients 16 years and older with moderate to severe Crohn’s disease.
[AbbVie, Inc. (BioSpace)]

Press Release

Erasca Announces First Patient Dosed in HERKULES-3, a Phase Ib/II Gastrointestinal Cancer Master Protocol Evaluating ERAS-007 in Multiple Combinations

Erasca, Inc. announced dosing of the first patient in HERKULES-3, a Phase Ib/II master protocol clinical trial evaluating ERAS-007 in combination with various agents in patients with gastrointestinal cancer, with initial focus on patients with advanced colorectal cancer.
[Erasca, Inc.]

Press Release

FEATURED EVENT

Gut Epithelial IL-27 Confers Intestinal Immunity through the Induction of Intraepithelial Lymphocytes

The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor–Dependent Metabolism in Myeloid Cells

TNF-α Synergizes with IFN-γ to Induce Caspase-8-JAK1/2-STAT1-Dependent Death of Intestinal Epithelial Cells

KLF5 Activates lncRNA DANCR and Inhibits Cancer Cell Autophagy Accelerating Gastric Cancer Progression

Thymus hirtus Sp. algeriensis Boiss. And Reut. Volatile Oil Enhances TRAIL/Apo2L Induced Apoptosis and Inhibits Colon Carcinogenesis through Upregulation of Death Receptor Pathway

E3 Ubiquitin Ligase SMURF2 Prevents Colorectal Cancer by Reducing the Stability of the YY1 Protein and Inhibiting the SENP1/C-Myc Axis

Long Noncoding RNA DLGAP1-AS2 Facilitates Wnt1 Transcription through Physically Interacting with Six3 and Drives the Malignancy of Gastric Cancer

Campylobacter concisus Upregulates PD-L1 mRNA Expression in IFN-γ Sensitized Intestinal Epithelial Cells and Induces Cell Death in Esophageal Epithelial Cells

Chlorothalonil Induces the Intestinal Epithelial Barrier Dysfunction in Caco-2 Cell-Based In Vitro Monolayer Model by Activating MAPK Pathway

Picropodophyllotoxin Induces G1/S Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway

Intestinal Interplay of Quorum Sensing Molecules and Human Receptors

AbbVie Submits Regulatory Application to FDA for Risankizumab-Rzaa (SKYRIZI^®) for the Treatment of Patients 16 Years and Older with Moderate to Severe Crohn’s Disease

Erasca Announces First Patient Dosed in HERKULES-3, a Phase Ib/II Gastrointestinal Cancer Master Protocol Evaluating ERAS-007 in Multiple Combinations

Cell-NCI Symposium: Beyond Cancer Genomics Toward Precision Oncology

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Scientist – Cancer Cell Signaling

Postdoctoral Associate – Mucosal Immunology

Faculty – Urology, Clinical Pharmacy

Faculty Position – Cancer Biology and Signal Transduction

Investigator – Host Immunity and Microbiome

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