 | | Vol. 7.40 – 22 October, 2021 |
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| Scientists uncovered important roles of enteric glial cells in intestinal homeostasis, immunity and tissue repair. They demonstrated that infection of mice with Heligmosomoides polygyrus led to enteric gliosis and the upregulation of an interferon gamma gene signature.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Intestinal epithelial cell (IEC) damage by T cells contributes to graft-versus-host disease, inflammatory bowel disease and immune checkpoint blockade-mediated colitis. The relevance of IEC-intrinsic succinate dehydrogenase A in mediating disease severity was confirmed by complementary chemical and genetic experimental approaches and validated in human clinical samples.
[Nature Immunology] |
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| Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in tumor-associated macrophages.
[Signal Transduction and Targeted Therapy] |
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| Genetic deletion of all miR-200s in the human gastric cancer cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated β-galactosidase activity, and aberrant metabolism, collectively resembling the senescent phenotype.
[Oncogene] |
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| Researchers investigated the biological effects of OLFM4-RET fusion and whether it could initiate tumorigenesis in small intestine.
[Oncogene] |
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| Scientists evaluated the functional role of BRD9 in gastrointestinal stromal tumors (GIST) progression. Their findings demonstrated that the expression of BRD9 was upregulated in GIST tissues.
[Cell Death & Disease] |
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| Researchers reported the finding that two clinically employed agents, everolimus and plicamycin, efficiently targeted the prototypic CMS4 cell line MDST8.
[Cell Death & Disease] |
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| Investigators investigated the expression of the N6-methyladenosine (m6A) regulator genes and their prognostic potential in a large clinical cohort of 173 gastric cancer patients using qRT-PCR assays.
[British Journal of Cancer] |
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| Researchers showed that miR-30c-5p expression was significantly down-regulated in gastric cancer tissues by comprehensive analysis using multiple databases.
[Scientific Reports] |
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| Focusing on human intestinal organoids, the authors highlight some of the key aspects that need to be considered and provide an outlook for future development in this exciting field.
[Environmental and Molecular Mutagenesis] |
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| Bristol Myers Squibb announced that the European Commission has approved Opdivo in combination with fluoropyrimidine- and platinum-based combination chemotherapy for the first-line treatment of adult patients with HER2-negative advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma whose tumors express PD-L1 with a combined positive score greater than equal to five.
[Bristol Myers Squibb] |
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| November 10 – 11, 2021
Seoul, Korea & Online |
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| University of Luxembourg – Luxembourg, Luxembourg |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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