 | | Vol. 7.41 – 29 October, 2021 |
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| Scientists reported that neurogenic differentiation factor 1 (NeuroD1) was positively correlated with glucose-6-phosphate dehydrogenase, the rate-limiting enzyme in the pentose phosphate pathway, in colorectal cancer cells.
[Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A combination of genetic and genomic approaches was used to define a critical role of intestinal epithelial cell-intrinsic negative elongation factor (NELF) complex in the maintenance of epithelial homeostasis.
[Mucosal Immunology] |
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| As toll-like receptor 4 (TLR4) agonists are known to regress solid tumors, scientists observed that lipopolysaccharide induced TOPORS via a TLR4–TRIF-dependent pathway, which in turn modulated the transcription of tumor suppressor scaffold/matrix attachment region-binding protein 1.
[Molecular Oncology] |
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| Investigators reported that the expression of lncRNA small nucleolar RNA host gene 22 (SNHG22) was significantly increased in gastric cancer tissues and cells, which conferred poor prognosis of patients.
[Cell Death & Disease] |
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| Researchers showed that ERp29 was a novel target for microRNA-135a-5p to inhibit the progression of colorectal cancer (CRC); correspondingly, ERp29 acted as an oncoprotein in CRC by promoting proliferation and metastasis of CRC cells, and suppressing apoptosis of the cells.
[Cell Death & Disease] |
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| The mechanisms underlying metastasis of colorectal cancer (CRC) remain unclear. In human CRC specimens, a decrease in C14orf159 expression at the invasive front of the tumor and in metastasis was determined.
[British Journal of Cancer] |
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| Investigators found that LINC00963 was aberrantly highly expressed in oxaliplatin-resistant SGC-7901 (SGC-7901-R) cells and promoted proliferation and migration and reduced the apoptosis rate in SGC-7901-R cells.
[Scientific Reports] |
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| Researchers showed antimigratory/invasive potential of Pseudevernia furfuracea methanol extract on HCT-116 and SW-480 colorectal carcinoma cell lines and elucidated possible mechanism of its action.
[Journal of Ethnopharmacology] |
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| The authors analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.
[Experimental Cell Research] |
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| Identifying a novel substrate of APC/β‑catenin may provide essential clues to develop effective drugs. Small interfering RNA technology and lentivirus‑mediated overexpression were performed for knockdown and overexpression of pleckstrin 2 in colorectal cancer cells.
[Molecular Medicine Reports] |
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| Investigators introduce the molecular mechanisms underlying the Hedgehog signaling pathway and its role in maintaining intestinal homeostasis.
[Cell Death & Disease] |
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| Scientists describe different gastrointestinal organoid methodologies and their applications for basic and translational cancer research.
[Experimental and Molecular Medicine] |
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| Immunic, Inc. announced that the final patient has been enrolled and randomized in its phase II CALDOSE-1 trial of lead asset, IMU-838, the company’s selective oral DHODH inhibitor, in patients with moderate-to-severe ulcerative colitis.
[Immunic, Inc.] |
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| November 10 – 19, 2021
Virtual |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of Luxembourg – Luxembourg, Luxembourg |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | Baylor College of Medicine – Houston, Texas, United States |
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