 | | Vol. 7.42 – 5 November, 2021 |
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| Scientists defined the regulation of enteric glial cells heterogeneity in homeostasis and chronic inflammatory bowel disease.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Researchers reported the impact of the interaction between serotonin (5-HT) and autophagy in colitis in mouse and human studies.
[Science Advances] |
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| The authors sequenced 73 pairs of colorectal cancer tissues and generated 147 H3K27ac ChIP-Seq, 144 RNA-Seq, 147 whole genome sequencing and 86 H3K4me3 ChIP-Seq samples.
[Nature Communications] |
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| Ephexin1 was reported to be highly upregulated by oncogenic Ras, but the functional consequences of this remain poorly understood. Investigators showed that Ephexin1 was highly expressed in colorectal cancer and lung cancer patient tissues.
[Cell Death & Disease] |
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| Scientists explicated a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer.
[British Journal of Cancer] |
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| The mechanisms underlying the abnormal expression of ATF3 and its biological function in gastric cancer (GC) have not been well investigated. Researchers reported ATF3 as one of the key regulators of GC development and progression.
[Experimental and Molecular Medicine] |
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| The authors investigated the mechanisms through which the Tricholoma matsutake-derived peptide, WFNNAGP, exerted protective effects on the inflammatory response and oxidative stress in a dextran sodium sulfate (DSS)-induced IBD mouse model.
[Food & Function] |
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| To study Hsp70 forms released from cells, scientists employed an assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA.
[Scientific Reports] |
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| The combined effect of diosmin and naringenin in colon cancer cell lines HCT116 and SW480 were assessed by targeting apoptosis and inflammatory pathways.
[Oncology Reports] |
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| Studies are continuing to explore the role of fecal microbiota transplantation (FMT) for many other conditions, including Crohn’s disease, functional gut disorders, metabolic syndrome, modulating responses to chemotherapy, eradication of multidrug resistant organisms, and the gut-brain axis.
[Journal of Gastroenterology and Hepatology] |
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| Ironwood Pharmaceuticals, Inc. announced that it is expanding its pipeline by entering into a collaboration and license option agreement with COUR Pharmaceutical Development Company, Inc.
[Ironwood Pharmaceuticals, Inc.] |
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| October 13 – 15, 2021
Virtual |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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