Intestinal Cell News Volume 7.43 | Nov 12 2021

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    2021-11-12 | ICN 7.43


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.43 – 12 November, 2021
    TOP STORY

    Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

    The authors observed elevated expression of full-length ECT2 protein in preneoplastic colon adenomas, driven by increased ECT2 mRNA abundance and associated with APC tumor suppressor loss.
    [Cancer Stem Cell News, Intestinal Cell News]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System

    A biphasic hyaluronan (HA) enema suspension, naïve-HA system that protected the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate-induced colitis mice model was reported.
    [Advanced Science]

    Full Article

    Functional Screen of Inflammatory Bowel Disease Genes Reveals Key Epithelial Functions

    Investigators identified 145 genes from IBD-associated genomic loci having endogenous expression within the intestinal epithelial cell compartment.
    [Genome Medicine]

    Full Article

    PRMT3 Promotes Tumorigenesis by Methylating and Stabilizing HIF1α in Colorectal Cancer

    The authors showed that HIF1α R282 was methylated by PRMT3, which was necessary for its stabilization and oncogene function. Analysis showed that PRMT3-mediated tumorigenesis was HIF1α methylation-dependent.
    [Cell Death & Disease]

    Full Article

    High PGD2 Receptor 2 Levels Are Associated with Poor Prognosis in Colorectal Cancer Patients and Induce VEGF Expression in Colon Cancer Cells and Migration in a Zebrafish Xenograft Model

    A colorectal cancer cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival.
    [British Journal of Cancer]

    Abstract

    Proteasome Inhibitors Restore the STAT1 Pathway and Enhance the Expression of MHC Class I on Human Colon Cancer Cells

    Scientists established that the baseline expression of major histocompatibility complex (MHC) class I alleles and programmed death-ligand 1 were generally low in colon cancer cell line models.
    [Journal of Biomedical Science]

    Full Article

    Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells

    Researchers identified the cell surface binding partner of regenerating gene 4 (Reg4) and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.
    [Molecular Cancer Research]

    Abstract

    Tumor-Associated Macrophages (TAMs) Depend on MMP1 for Their Cancer-Promoting Role

    The authors demonstrated that matrix metalloproteinase 1 (MMP1) derived from TAMs markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.
    [Cell Death Discovery]

    Full Article

    Loss of Aryl Hydrocarbon Receptor Suppresses the Response of Colonic Epithelial Cells to IL22 Signaling by Upregulating SOCS3

    Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo.
    [American Journal of Physiology-Gastrointestinal and Liver Physiology]

    Abstract

    Ring Finger 220 Promotes the Stemness and Progression of Colon Cancer Cells via Ubiquitin Specific Peptidase 22-BMI1 Axis

    Investigators found that ring finger 22020 was upregulated in colorectal cancer in patients and cell models. RT-PCR assay was used to compare differences between expression levels of RNF220 in colorectal tumor and normal tissues.
    [Bioengineered]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Natural-Derived Alkaloids Exhibit Great Potential in the Treatment of Ulcerative Colitis

    The research and development of new drugs for the treatment of ulcerative colitis is urgent, and natural alkaloids are an important source.
    [Pharmacological Research]

    AbstractGraphical Abstract

    Branching Crypts in Inflammatory Bowel Disease Revisited

    Although the biological significance of asymmetric crypt-branching in IBD remains at present elusive, their occurrence deserves to be further investigated.
    [Journal of Gastroenterology and Hepatology]

    AbstractFull Article

    INDUSTRY AND POLICY NEWS

    Novome Biotechnologies and Genentech Enter into a Strategic Collaboration to Develop Targets Against Inflammatory Bowel Disease

    Novome Biotechnologies, Inc. announced a multi-year research collaboration and licensing agreement with the Genentech platform to discover, engineer and develop bacterial strains that express and deliver specific therapeutically relevant molecules to targets in the human intestinal tract.
    [Novome Biotechnologies, Inc.]

    Press Release

    Biomerica Receives Notice of Allowance from Canadian Patent Office for Patent Covering Irritable Bowel Syndrome (IBS) Food Sensitivity Testing & Treatment

    Biomerica, Inc. announced that the Canadian Patent Office has issued a notice of allowance for Biomerica’s patent application pertaining to the company’s InFoods® diagnostic guided therapy platform technology that offers a novel approach in the treatment of patients suffering from IBS.
    [Biomerica, Inc.]

    Press Release
    FEATURED EVENT

    Stem Cell Society Singapore Symposium 2021

    December 8 – 9, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Epithelial Cell Physiology

    University of Houston – Houston, Texas, United States

    Postdoctoral Fellow – Bioinformatics

    University Medical Center Schleswig-Holstein – Kiel, Germany

    Postdoctoral Fellow – Intestinal Homeostasis

    University of North Dakota – Grand Forks, North Dakota, United States

    Research Technician – Regeneration

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Senior Researcher – Cancer Progression and Metastasis

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    > See All Jobs

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