| Vol. 7.43 – 12 November, 2021 |
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| The authors observed elevated expression of full-length ECT2 protein in preneoplastic colon adenomas, driven by increased ECT2 mRNA abundance and associated with APC tumor suppressor loss. [Cancer Stem Cell News, Intestinal Cell News] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| A biphasic hyaluronan (HA) enema suspension, naïve-HA system that protected the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate-induced colitis mice model was reported. [Advanced Science] |
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| Investigators identified 145 genes from IBD-associated genomic loci having endogenous expression within the intestinal epithelial cell compartment. [Genome Medicine] |
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| The authors showed that HIF1α R282 was methylated by PRMT3, which was necessary for its stabilization and oncogene function. Analysis showed that PRMT3-mediated tumorigenesis was HIF1α methylation-dependent. [Cell Death & Disease] |
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| A colorectal cancer cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. [British Journal of Cancer] |
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| Scientists established that the baseline expression of major histocompatibility complex (MHC) class I alleles and programmed death-ligand 1 were generally low in colon cancer cell line models. [Journal of Biomedical Science] |
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| Researchers identified the cell surface binding partner of regenerating gene 4 (Reg4) and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results. [Molecular Cancer Research] |
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| The authors demonstrated that matrix metalloproteinase 1 (MMP1) derived from TAMs markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase. [Cell Death Discovery] |
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| Scientists showed that IL22 treatment induced the phosphorylation of STAT3, inhibited colonic organoid growth, and promoted colonic cell proliferation in vivo. [American Journal of Physiology-Gastrointestinal and Liver Physiology] |
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| Investigators found that ring finger 22020 was upregulated in colorectal cancer in patients and cell models. RT-PCR assay was used to compare differences between expression levels of RNF220 in colorectal tumor and normal tissues. [Bioengineered] |
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| The research and development of new drugs for the treatment of ulcerative colitis is urgent, and natural alkaloids are an important source. [Pharmacological Research] |
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| Although the biological significance of asymmetric crypt-branching in IBD remains at present elusive, their occurrence deserves to be further investigated. [Journal of Gastroenterology and Hepatology] |
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| Novome Biotechnologies, Inc. announced a multi-year research collaboration and licensing agreement with the Genentech platform to discover, engineer and develop bacterial strains that express and deliver specific therapeutically relevant molecules to targets in the human intestinal tract. [Novome Biotechnologies, Inc.] |
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| Biomerica, Inc. announced that the Canadian Patent Office has issued a notice of allowance for Biomerica’s patent application pertaining to the company’s InFoods® diagnostic guided therapy platform technology that offers a novel approach in the treatment of patients suffering from IBS. [Biomerica, Inc.] |
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| December 8 – 9, 2021 Virtual |
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| University of Houston – Houston, Texas, United States |
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| University Medical Center Schleswig-Holstein – Kiel, Germany |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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