Intestinal Cell News Volume 7.44 | Nov 19 2021

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    2021-11-19 | ICN 7.44


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.44 – 19 November, 2021
    TOP STORY

    Fusobacterium nucleatum Enhances the Efficacy of PD-L1 Blockade in Colorectal Cancer

    Fusobacterium nucleatum induces different immune responses in colorectal cancer (CRC) with different microsatellite-instability statuses. Scientists investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Infection and Replication in Human Gastric Organoids

    Researchers generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection.
    [Nature Communications]

    Full Article

    Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage

    Scientists showed that smooth muscle cells may have been the dominant suppliers of BMP antagonists, which were niche factors essential for intestinal stem cell maintenance.
    [Nature Communications]

    Full Article

    Cetuximab Promotes RSL3-Induced Ferroptosis by Suppressing the Nrf2/HO-1 Signalling Pathway in KRAS Mutant Colorectal Cancer

    Researchers investigated whether cetuximab-mediated regulation of p38/Nrf2/HO-1 promoted RSL3-induced ferroptosis and played a pivotal role in overcoming drug resistance in KRAS mutant colorectal cancer.
    [Cell Death & Disease]

    Full Article

    Effects of Emulsifiers on an In Vitro Model of Intestinal Epithelial Tight Junctions and the Transport of Food Allergens

    The authors challenged Caco-2 cell monolayers, an in vitro model of human intestinal epithelial tight junctions with synthetic polysorbate-80 or natural lecithin alone, or in combination with known allergens.
    [Molecular Nutrition & Food Research]

    Abstract

    Tumor Suppressor LHX6 Upregulation Contributes to the Inhibitory Effect of miR-346 Knockdown on Colorectal Cancer Cell Growth

    Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients.
    [Environmental Toxicology]

    Abstract

    Kaempferol Sensitizes Cell Proliferation Inhibition in Oxaliplatin-Resistant Colon Cancer Cells

    Investigators provided important evidence that kaempferol targeting RSKs might be a strategy to reduce the oxaliplatin-resistant colon cancer cells.
    [Archives of Pharmacal Research]

    Abstract

    Combination of Resveratrol and BIBR1532 Inhibits Proliferation of Colon Cancer Cells by Repressing Expression of LncRNAs

    Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells.
    [Medical Oncology]

    Abstract

    Deep-Frying Oil Induces Cytotoxicity, Inflammation, and Apoptosis on Intestinal Epithelial Cells

    Bioinformatics and cell biology were used to investigate the functions and signal pathway enrichments of differentially expressed genes.
    [Journal of the Science of Food and Agriculture]

    Abstract

    HIG1 Domain Family Member 1A Disrupts Proliferation, Migration and Invasion of Colon Adenocarcinoma Cells

    Higd-1a promotes the proliferation of pancreatic cancer cells and the growth of pancreatic cancer; however, no similar observations have been reported for colorectal cancer (CRC). Researchers verified the role of Higd-1a in CRC.
    [Bioengineered]

    Full Article

    Guide to everything you need to know about cell separation.
    REVIEWS

    Foundations of Gastrointestinal-Based Drug Delivery and Future Developments

    The authors examine the fundamentals of gastrointestinal drug delivery to inform clinicians and pharmaceutical scientists.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Connect Biopharma Completes Enrollment of CBP-307 Global Phase II Clinical Trial in Moderate-to-Severe Ulcerative Colitis

    Connect Biopharma Holdings Limited announced that it has completed full enrollment of phase II clinical trial evaluating CBP-307 in adult patients with moderate-to-severe ulcerative colitis.
    [Connect Biopharma Holdings Ltd.]

    Press Release

    FEATURED EVENT

    Cell Bio Virtual 2021

    December 1 – 10, 2021
    Virtual

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    JOB OPPORTUNITIES

    Professor – Gut-Liver Axis

    KU Leuven – Leuven, Belgium

    Postdoctoral Fellow – Epithelial Cell Physiology

    University of Houston – Houston, Texas, United States

    Postdoctoral Fellow – Bioinformatics

    University Medical Center Schleswig-Holstein – Kiel, Germany

    Postdoctoral Fellow – Intestinal Homeostasis

    University of North Dakota – Grand Forks, North Dakota, United States

    Research Technician – Regeneration

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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