| Vol. 7.44 – 19 November, 2021 |
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| Fusobacterium nucleatum induces different immune responses in colorectal cancer (CRC) with different microsatellite-instability statuses. Scientists investigated the effect of F. nucleatum on anti-PD-L1 therapy in CRC. [Signal Transduction and Targeted Therapy] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection. [Nature Communications] |
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| Scientists showed that smooth muscle cells may have been the dominant suppliers of BMP antagonists, which were niche factors essential for intestinal stem cell maintenance. [Nature Communications] |
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| Researchers investigated whether cetuximab-mediated regulation of p38/Nrf2/HO-1 promoted RSL3-induced ferroptosis and played a pivotal role in overcoming drug resistance in KRAS mutant colorectal cancer. [Cell Death & Disease] |
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| The authors challenged Caco-2 cell monolayers, an in vitro model of human intestinal epithelial tight junctions with synthetic polysorbate-80 or natural lecithin alone, or in combination with known allergens. [Molecular Nutrition & Food Research] |
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| Dysregulated miRNAs have been promulgated as oncogenes or tumor-suppressive genes participating in the initiation and progression of colorectal cancer (CRC). Scientists reported that miR-346 was highly expressed in CRC patients. [Environmental Toxicology] |
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| Investigators provided important evidence that kaempferol targeting RSKs might be a strategy to reduce the oxaliplatin-resistant colon cancer cells. [Archives of Pharmacal Research] |
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| Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells. [Medical Oncology] |
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| Bioinformatics and cell biology were used to investigate the functions and signal pathway enrichments of differentially expressed genes. [Journal of the Science of Food and Agriculture] |
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| Higd-1a promotes the proliferation of pancreatic cancer cells and the growth of pancreatic cancer; however, no similar observations have been reported for colorectal cancer (CRC). Researchers verified the role of Higd-1a in CRC. [Bioengineered] |
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| The authors examine the fundamentals of gastrointestinal drug delivery to inform clinicians and pharmaceutical scientists. [Nature Reviews Gastroenterology & Hepatology] |
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| Connect Biopharma Holdings Limited announced that it has completed full enrollment of phase II clinical trial evaluating CBP-307 in adult patients with moderate-to-severe ulcerative colitis. [Connect Biopharma Holdings Ltd.] |
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| December 1 – 10, 2021 Virtual |
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| KU Leuven – Leuven, Belgium |
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| University of Houston – Houston, Texas, United States |
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| University Medical Center Schleswig-Holstein – Kiel, Germany |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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