Intestinal Cell News Volume 7.47 | Dec 10 2021

    By
    Justin.choi
    -
    0
    25







    2021-12-10 | ICN 7.47


    Intestinal Cell News by STEMCELL Technologies
    Vol. 7.47 – 10 December, 2021
    TOP STORY

    Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

    Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human pluripotent stem cell.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    All Layers Matter: Innovative Three-Dimensional Epithelium-Stroma-Endothelium Intestinal Model for Reliable Permeability Outcomes

    Scientists developed an advanced three-dimensional in vitro intestinal model to test absorption in a more reliable manner, by better mimicking the native environment.
    [Journal of Controlled Release]

    AbstractGraphical Abstract

    Manuka Honey in Combination with 5-Fluorouracil Decreases Physical Parameters of Colonspheres Enriched with Cancer Stem-Like Cells and Reduces Their Resistance to Apoptosis

    Investigators evaluated the in vitro effect of Manuka honey and its combination with 5-Fluorouracil, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate.
    [Food Chemistry]

    Abstract

    Lactobacillus plantarum Alleviates Irradiation-Induced Intestinal Injury by Activation of FXR-FGF15 Signaling in Intestinal Epithelia

    Scientists characterized that Lactobacillus plantarum activated the farnesoid X receptor – fibroblast growth factor 15 signaling in intestinal epithelial cells and hence promoted DNA-damage repair.
    [Journal of Cellular Physiology]

    Abstract

    Corticotropin Releasing Hormone Promotes Inflammatory Bowel Disease via Inducing Intestinal Macrophage Autophagy

    Researchers investigated the underlying mechanism of psychosocial stress in an inflammatory bowel disease mouse model pertaining to macrophage autophagy.
    [Cell Death Discovery]

    Abstract

    p53-Mediated G1 Arrest Requires the Induction of Both p21 and Killin in Human Colon Cancer Cells

    Knockout of killin in human colorectal cells led to a dramatic decrease in p53-mediated G1 arrest upon DNA damage.
    [Cell Cycle]

    Abstract

    Xanthohumol Reduces Inflammation and Cell Metabolism in HT29 Primary Colon Cancer Cells

    Scientists analyzed the effect of xanthohumol on a primary colorectal adenocarcinoma cell line, HT29, on cell viability, inflammatory and antioxidant gene expression, and metabolism.
    [International Journal of Food Sciences and Nutrition]

    Abstract

    Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways

    The expression level of relative proteins in mTOR pathway was detected by western blot assay to investigate the mechanism of Qingjie Fuzheng granule effect on colorectal cancer cells.
    [Evidence-Based Complementary and Alternative Medicine]

    Full Article

    Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

    Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.
    [Bioengineered]

    Full Article

    On-demand Webinar on Studying Cystic Fibrosis using Primary Human Nasal Epithelial Cells - Watch Now
    REVIEWS

    Revisiting Fibrosis in Inflammatory Bowel Disease: The Gut Thickens

    Scentists present the state of the art on the most recently identified pathogenic mechanisms of this serious inflammatory bowel disease-related complication, focusing on possible targets of antifibrotic therapies, management strategies, and factors that might predict fibrosis progression or response to treatment.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Celularity Announces FDA Clearance of Investigational New Drug Application (IND) for Natural Killer Cell Therapy CYNK-101 in First-Line Advanced Her2/Neu Positive Gastric and Gastroesophageal Junction Cancer

    Celularity Inc. announced the US FDA has cleared its Investigational New Drug application for the use of CYNK-101 in combination with standard chemotherapy, trastuzumab and pembrolizumab in patients with first-line locally advanced unresectable or metastatic HER2/neu positive gastric or gastroesophageal junction adenocarcinoma.
    [Celularity, Inc. (GlobenewsWire, Inc.)]

    Press Release

    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Colorectal Cancer

    Princess Margaret Cancer Centre – Toronto, Ontario, Canada

    PhD Scholar – Translational Biomedicine

    Technical University of Denmark – Lyngby, Denmark

    Postdoctoral Fellow – Cancers and Infections

    Lund University – Malmö, Sweden

    Professor – Gut-Liver Axis

    KU Leuven – Leuven, Belgium

    Postdoctoral Research Fellow – Bioinformatics

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Intestinal Cell News Twitter