Intestinal Cell News Volume 8.01 | Jan 14 2022

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    2022-01-14 | ICN 8.01


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.01 – 14 January, 2022
    TOP STORY

    Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells

    Investigators employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human intestinal stem cells from the duodenum and rectum.
    [Nature Communications]

    Full Article

    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Adaptive Differentiation Promotes Intestinal Villus Recovery

    Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

    The authors found that CDC42 loss initiated in intestinal stem cells caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Redox-Dependent Internalization of the Purinergic P2Y6 Receptor Limits Colitis Progression

    Researchers identified a mechanism of redox-dependent alternative internalization that promoted the internalization and degradation of the purinergic P2Y6 receptor.
    [Science Signaling]

    Abstract

    Linc01133 Contributes to Gastric Cancer Growth by Enhancing YES1-Dependent YAP1 Nuclear Translocation via Sponging miR-145-5p

    Scientists found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients.
    [Cell Death & Disease]

    Full Article

    Immune Subtypes and Neoantigen-Related Immune Evasion in Advanced Colorectal Cancer

    Scientist analyzed immune subtypes and immune evasion via neoantigen-related mechanisms and identified a distinctive cancer subtype characterized by immune evasion and very poor overall survival.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Transcriptomic Profiling of Single Circulating Tumor Cells Provides Insight into Human Metastatic Gastric Cancer

    Researchers utilized an antigen-independent strategy for circulating tumor cell (CTC) isolation from metastatic gastric cancer patients involving a size-dependent recovery of CTCs and a single cell isolation technique.
    [Communications Biology]

    Full Article

    GPR120 Prevents Colorectal Adenocarcinoma Progression by Sustaining the Mucosal Barrier Integrity

    Researchers explored the involvement of epithelial GPR120 in the colorectal cancer development. Both in vitro and in vivo experiments were conducted to mimic the conditional deletion of the receptor from gut epithelium.
    [Scientific Reports]

    Full Article

    Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells

    Scientists designed the first hydrophobic tagging-based PDEδ degraders. Compound 17c efficiently bound to PDEδ and induced degradation of PDEδ in SW480 colon cancer cells.
    [ACS Medicinal Chemistry Letters]

    AbstractGraphical Abstract

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    REVIEWS

    Protective Effects of Physical Activity in Colon Cancer and Underlying Mechanisms: A Review of Epidemiological and Biological Evidence

    The authors provide an overview of the epidemiological evidence to date which comprises 16 cohort studies of the effects of physical activity on colon cancer outcomes including cancer recurrence, cancer-specific and overall survival.
    [Critical Reviews in Oncology Hematology]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    G-Tech Medical Receives FDA Clearance for Its Gastrointestinal Motility Monitoring System

    G-Tech Medical, announced US FDA 510(k) clearance of its Wireless Patch System for non-invasive myoelectric activity measurement.
    [G-tech Medical]

    Press Release

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Intestinal Inflammation

    University of North Dakota – Grand Forks, North Dakota, United States

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    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

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    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Colorectal Cancer

    Princess Margaret Cancer Centre – Toronto, Ontario, Canada

    Professor – Gut-Liver Axis

    KU Leuven – Leuven, Belgium

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