Intestinal Cell News Volume 8.05 | Feb 11 2022

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    2022-02-11 | ICN 8.05


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.05 – 11 February, 2022
    TOP STORY

    Epithelial Gasdermin D Shapes the Host-Microbial Interface by Driving Mucus Layer Formation

    Scientists linked epithelial Gasdermin D to the secretory granule exocytotic pathway and highlighted its physiological nonpyroptotic role in shaping mucosal homeostasis in the gut.
    [Science Immunology]

    Full Article

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Aspirin Activates Resolution Pathways to Reprogram T Cell and Macrophage Responses in Colitis-Associated Colorectal Cancer

    The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.
    [Science Advances]

    Full Article

    Mesenchymal-Epithelial Crosstalk Shapes Intestinal Regionalization via Wnt and Shh Signaling

    Scientists identified a mesenchymal-epithelial crosstalk that shaped the developing small intestine during late morphogenesis.
    [Nature Communications]

    Full Article

    The Yun/Prohibitin Complex Regulates Adult Drosophila Intestinal Stem Cell Proliferation through the Transcription Factor E2F1

    From an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), researchers identified a factor, Yun, required for proliferation of normal and transformed ISCs.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    PTBP3 Modulates P53 Expression and Promotes Colorectal Cancer Cell Proliferation by Maintaining UBE4A mRNA Stability

    PTBP3 knockdown in colorectal cancer cell (CRC) lines restricted CRC proliferative capacities in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    The KDM6A-SPARCL1 Axis Blocks Metastasis and Regulates the Tumor Microenvironment of Gastrointestinal Stromal Tumors by Inhibiting the Nuclear Translocation of p65

    CCK-8, live cell count, colony formation, wound-healing and Transwell migration and invasion assays were employed to detect the cell proliferation, migration and invasion.
    [British Journal of Cancer]

    Abstract

    Fabrication, Characterization and In Vitro Evaluation of Disulfiram-Loaded Cellulose Acetate/Poly(ethylene Oxide) Nanofiber Scaffold for Breast and Colon Cancer Cell Lines Treatment

    Disulfiram (DS)@CA/PEO nanofiber scaffold showed higher safety than DS-free on human normal cells with revealing similar anticancer activity of DS-free against colon cancer lines and breast cancer lines.
    [International Journal of Biological Macromolecules]

    Abstract

    2′-Fucosyllactose Promotes Lactobacillus rhamnosus KLDS 8001 to Repair LPS-Induced Damage in Caco-2 Cells

    Researchers investigated the effect of 2′-fucosyllactose on the repair of monolayer barrier damage in Caco-2 cells by Lactobacillus rhamnosus KLDS 8001 (KLDS 8001).
    [Journal of Food Biochemistry]

    Abstract

    Apoptosis Induction in Human Lung and Colon Cancer Cells via Impeding VEGF Signaling Pathways

    Researchers assessed the suppressing effect of VGB4, a vascular endothelial growth factor (VEGF) antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29.
    [Molecular Biology Reports]

    Abstract

    Ex Vivo Organotypic Cultures for Synergistic Therapy Prioritization Identify Patient-Specific Responses to Combined MEK and Src Inhibition in Colorectal Cancer

    Scientists prioritized the top five synergistic combinations from a large in vitro screen for ex vivo testing on 29 freshly resected human colorectal cancer tumors and found that only the combination of mitogen-activated protein kinase and proto-oncogene tyrosine-protein kinase Src inhibition was effective when tested ex vivo.
    [Nature Cancer]

    Full Article

    Request a free copy of the Growing Organoids from Stem Cells Wallchart
    REVIEWS

    Intestinal Stem Cell Dynamics in Homeostasis and Cancer

    The authors highlight the importance of stem cell/niche interactions in developing and established colorectal cancer and discuss how these can be modulated to develop novel preventive and therapeutic interventions.
    [Trends in Cancer]

    Full Article

    INDUSTRY AND POLICY NEWS

    Second Genome Nominates Development Candidate Targeting PAI-1/2 for the Treatment of Inflammatory Bowel Disease (IBD)

    Second Genome, announced that the company will advance SG-5-00455, which targeted plasminogen activator inhibitor – I/II, as a development candidate for the treatment of IBD.
    [Second Genome]

    Press Release

    FEATURED EVENT

    ISCT ANZ – BAA Joint Scientific Meeting

    February 24 – February 25, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Positions – Molecular Cancer Research

    University of Copenhagen – Copenhagen, Denmark

    Research Associate – Gastroenterology

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellow – Intestinal Inflammation

    University of North Dakota – Grand Forks, North Dakota, United States

    Research Fellow – Adenocarcinoma

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Associate – Molecular and Cellular Biology

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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