| Vol. 8.05 – 11 February, 2022 |
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| Scientists linked epithelial Gasdermin D to the secretory granule exocytotic pathway and highlighted its physiological nonpyroptotic role in shaping mucosal homeostasis in the gut. [Science Immunology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer. [Science Advances] |
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| Scientists identified a mesenchymal-epithelial crosstalk that shaped the developing small intestine during late morphogenesis. [Nature Communications] |
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| From an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), researchers identified a factor, Yun, required for proliferation of normal and transformed ISCs. [Proceedings of the National Academy of Sciences of the United States of America] |
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| PTBP3 knockdown in colorectal cancer cell (CRC) lines restricted CRC proliferative capacities in vitro and in vivo. [Cell Death & Disease] |
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| CCK-8, live cell count, colony formation, wound-healing and Transwell migration and invasion assays were employed to detect the cell proliferation, migration and invasion. [British Journal of Cancer] |
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| Disulfiram (DS)@CA/PEO nanofiber scaffold showed higher safety than DS-free on human normal cells with revealing similar anticancer activity of DS-free against colon cancer lines and breast cancer lines. [International Journal of Biological Macromolecules] |
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| Researchers investigated the effect of 2′-fucosyllactose on the repair of monolayer barrier damage in Caco-2 cells by Lactobacillus rhamnosus KLDS 8001 (KLDS 8001). [Journal of Food Biochemistry] |
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| Researchers assessed the suppressing effect of VGB4, a vascular endothelial growth factor (VEGF) antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29. [Molecular Biology Reports] |
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| Scientists prioritized the top five synergistic combinations from a large in vitro screen for ex vivo testing on 29 freshly resected human colorectal cancer tumors and found that only the combination of mitogen-activated protein kinase and proto-oncogene tyrosine-protein kinase Src inhibition was effective when tested ex vivo. [Nature Cancer] |
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| The authors highlight the importance of stem cell/niche interactions in developing and established colorectal cancer and discuss how these can be modulated to develop novel preventive and therapeutic interventions. [Trends in Cancer] |
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| Second Genome, announced that the company will advance SG-5-00455, which targeted plasminogen activator inhibitor – I/II, as a development candidate for the treatment of IBD. [Second Genome] |
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| February 24 – February 25, 2022 Virtual |
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| University of Copenhagen – Copenhagen, Denmark |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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