 | | Vol. 8.06 – 18 February, 2022 |
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| The authors showed that Fusobacterium nucleatum promoted colorectal cancer stem-like cells (CCSCs) self-renewal, and non-CCSCs to acquire CCSC features by manipulating cellular lipid accumulation.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.
[Nature Communications] |
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| Scientists screened a compound library for synergy with low-dose BCL-XL inhibitor A-1155463 to identify pathways that regulated sensitivity to BCL-XL inhibition and revealed that fibroblast growth factor receptor 4 (FGFR4) inhibition effectively sensitized to A-1155463 both in vitro and in vivo.
[Cell Reports] |
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| Researchers described suspension culture as a simple, low-maintenance method for culturing human intestinal organoids and for promoting in vitro differentiation of an organized serosal mesothelial layer that was similar to primary human intestinal serosal mesothelium.
[Cell Reports] |
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| Scientists demonstrated that oncogenic LINC021 specifically bound with the m6A “reader” insulin-like growth factor-2 mRNA-binding protein 2 (IMP2) protein and enhanced the mRNA stability of MSX1 and JARID2 in an m6A regulatory manner during colorectal cancer tumorigenesis and pathogenesis.
[Oncogene] |
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| A mutational tumor profile was examined using a customized gene panel. Immunofluorescence was used to identify the cellular location of punctate IKKα expression.
[British Journal of Cancer] |
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| Researchers validated that PDX1, EN2 and MSX1 genes had oncogenic features in colorectal cancer and that their expression levels were increased in correlation with the hypermethylation of intragenic regions.
[Experimental & Molecular Medicine] |
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| Within LPS-treated MODE-K cells, METTL3 knockdown promoted cell viability, inhibited cell apoptosis, decreased apoptotic caspase3/9 cleavage, and decreased the levels of proinflammatory cytokines and inflammatory enzymes.
[Cell Death Discovery] |
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| Scientists addressed the relevance of 3D organoid technology to investigate the biological effects of cold atmospheric plasma on normal epithelial stem cells and tumor cells isolated from mouse small intestine.
[Cell Death Discovery] |
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| The authors summarize the critical mediators and mechanisms involved in immune cell trafficking in IBD and the available evidence for efficacy, safety and pharmacokinetics of sphingosine 1-phosphate receptor modulators in IBD and other immune-mediated disorders.
[Nature Reviews Gastroenterology & Hepatology] |
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| Celularity, Inc. announced the US FDA has granted Orphan Drug Designation for its investigational natural killer cell therapy, CYNK-101, for treatment of gastric/gastroesophageal junction cancer.
[Celularity Inc.] |
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| March 19 – 22, 2022
Sitges, Spain |
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| Baylor College of Medicine – Houston, Texas, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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