Intestinal Cell News Volume 8.08 | Mar 4 2022

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    2022-03-04 | ICN 8.08


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.08 – 4 March, 2022
    TOP STORY

    3D Bioprinted GelMA-Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells through Activating Wnt/β-Catenin Signaling

    Researchers found that gelatin methacryloyl (GelMA)-nanoclay hybrid hydrogels could induce and enrich colorectal cancer stem cells assisted by 3D bioprinting.
    [Small]

    Full Article

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Exposure to the Mycotoxin Deoxynivalenol Reduces the Transport of Conjugated Bile Acids by Intestinal Caco-2 Cells

    The authors explored the effects of deoxynivalenol exposure on the intestinal absorption of conjugated bile acids and the expression of bile acid transporters using an in vitro model based on Caco-2 cell layers grown in transwells.
    [Archives of Toxicology]

    Full Article

    Phycocyanin Ameliorates Mouse Colitis via Phycocyanobilin-Dependent Antioxidant and Anti-inflammatory Protection of the Intestinal Epithelial Barrier

    Flow cytometry analysis of phycocyanobilin fluorescence in Caco-2 cells unveiled a similar uptake efficacy of phycocyanin and phycocyanobilin by intestinal epithelial cells.
    [Food & Function]

    AbstractGraphical Abstract

    Involvement of TMEM16A/ANO1 Upregulation in the Oncogenesis of Colorectal Cancer

    Scientists showed that ANO1 channel protein was upregulated in human colorectal cancer tissue samples and its upregulation was correlated with the TNM staging, histological type, pathological differentiation and poor prognosis.
    [Biochimica Et Biophysica Acta-Molecular Cell Research]

    Abstract

    Tumor RNA Transfected DCs Derived from iPS Cells Elicit Cytotoxicity against Cancer Cells Induced from Colorectal Cancer Patients In Vitro

    Researchers investigated induced pluripotent stem (iPS) dendritic cells-in vitro transcriptional RNA (ivtRNA) which were induced by transfecting ivtRNA obtained from tumors of three colorectal cancer patients, and examined its antitumor effect.
    [Scientific Reports]

    Full Article

    Spatial Distribution of Live Gut Microbiota and Bile Acid Metabolism in Various Parts of Human Large Intestine

    Investigators analyzed the live composition of luminal microbiota and mucosa-associated microbiota in the ascending and descending colons and the rectums of ten healthy adults and compared it with the total composition.
    [Scientific Reports]

    Full Article

    Boric Acid Suppresses Cell Proliferation by TNF Signaling Pathway Mediated Apoptosis in SW-480 Human Colon Cancer Line

    Scientists investigated whether boric acid could be a new candidate molecule that could be used in the treatment of colon cancer.
    [Journal of Trace Elements in Medicine and Biology]

    Abstract

    The Anticancer Effect of a Conjugated Antimicrobial Peptide against Colorectal Cancer (CRC) Cells

    Researchers evaluated the anticancer effect of MELITININ+BMAP27-conjugated peptide against CRCs.
    [Journal of Gastrointestinal Cancer]

    Abstract

    Cancer Stem Cell Markers CD44v9+/CD133 Are Associated with Low Apoptosis in Both Sporadic and Ulcerative Colitis-Associated Colorectal Cancers

    To elucidate tumor cell behavior associated with cancer stem cells (CSC) marker expression, the expression of CD133, CD44v9, and ALDH1A1, which are considered markers of CSCs, was examined in sporadic and ulcerative colitis-associated colorectal tumors.
    [Histology and Histopathology]

    Abstract

    Free cell culture training with self-paced, on-demand courses.
    REVIEWS

    Building Gut from Scratch — Progress and Update of Intestinal Tissue Engineering

    Scientists discuss the latest advances in the components required to engineer intestinal grafts and summarize the progress of intestinal tissue engineering.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    MicroRNAs and Drug Resistance in Colorectal Cancer with Special Focus on 5-Fluorouracil

    The authors review and discuss the role of selected microRNAs in 5-fluorouracil resistance and their molecular mechanisms in colorectal cancer.
    [Molecular Biology Reports]

    Abstract

    INDUSTRY AND POLICY NEWS

    Elgan Pharma Announces Positive Results from Its Phase III Study of ELGN-GI in Preterm Infants for Treatment of Intestinal Malabsorption

    Elgan Pharma released the findings of its Phase III study on the safety and efficacy of an insulin formulation for the treatment of intestinal malabsorption in preterm infants, called ELGN-gastrointestinal (GI).
    [Elgan Pharma (BioSpace, Inc.)]

    Press Release

    FEATURED EVENT

    Sy-Stem 2022

    March 20 – March 25, 2022
    Vienna, Austria

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    JOB OPPORTUNITIES

    PhD Scientist – Oncology

    University of Virginia School of Medicine – Charlottesville, Virginia, United States

    Postdoctoral Researcher – Intestinal Organoid

    Baylor College of Medicine – Houston, Texas, United States

    Senior Research Scientist II – Therapeutics

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Researcher – Intestinal Organoid

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Intestinal Inflammation

    University of North Dakota – Grand Forks, North Dakota, United States

    > See All Jobs

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