Intestinal Cell News Volume 8.09 | Mar 11 2022

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    2022-03-11 | ICN 8.09


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.09 – 11 March, 2022
    TOP STORY

    Modeling Colorectal Cancer: A Bio-Resource of 50 Patient-Derived Organoid Lines

    The authors examined the potential utility of patient-derived colorectal cancer organoids in a personalized cancer medicine setting.
    [Gastroenterology]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity

    circREEP3 was found to be upregulated in colorectal cancer tissues. circREEP3 upregulation predicted poor patient survival.
    [Advanced Science]

    Full Article

    Fusobacterium nucleatum Reduces METTL3-Mediated m6A Modification and Contributes to Colorectal Cancer Metastasis

    Researchers uncovered that Fusobacterium nucleatum induced a dramatic decline of m6A modifications in CRC cells and patient-derived xenograft tissues by downregulation of an m6A methyltransferase METTL3, contributing to inducation of CRC aggressiveness.
    [Nature Communications]

    Full Article

    Epithelial GPR35 Protects from Citrobacter rodentium Infection by Preserving Goblet Cells and Mucosal Barrier Integrity

    Scientists showed that epithelial Gpr35 played a critical role in goblet cell function. In mice, cell-type-specific deletion of Gpr35 in epithelial cells but not in macrophages resulted in goblet cell depletion and dysbiosis, rendering these animals more susceptible to Citrobacter rodentium infection.
    [Mucosal Immunology]

    Full Article

    MicroRNA-301b-3p from Mesenchymal Stem Cells-Derived Extracellular Vesicles Inhibits TXNIP to Promote Multidrug Resistance of Gastric Cancer Cells

    Scientists explored the role of mesenchymal stem cells (MSC)-derived extracellular vesicles-derived miR-301b-3p in multidrug resistance of gastric cancer cells.
    [Cell Biology and Toxicology]

    Abstract

    Upregulation of BMI1-Suppressor miRNAs (miR-200c, miR-203) during Terminal Differentiation of Colon Epithelial Cells

    Researchers identified miRNAs that were upregulated during terminal differentiation in the human colon epithelium, and elucidated their role in the mechanistic control of stem cell properties.
    [Journal of Gastroenterology]

    Full Article

    Characterization of the MicroRNA Profile of Ginger Exosome-Like Nanoparticles and Their Anti-Inflammatory Effects in Intestinal Caco-2 Cells

    The miRNA profiles in ginger and ginger exosome-like nanoparticles were analyzed using high-throughput sequencing, and the results of the sequencing were validated by real-time quantitative polymerase chain reaction.
    [Journal of Agricultural and Food Chemistry]

    Abstract

    CARM1 Promotes Gastric Cancer Progression by Regulating TFE3 Mediated Autophagy Enhancement through the Cytoplasmic AMPK-mTOR and Nuclear AMPK-CARM1-TFE3 Signaling Pathways

    Scientists explored whether CARM1 was involved in the progression of gastric cancer by regulating autophagy.
    [Cancer Cell International]

    Full Article

    Hsa-miR-186-3p Suppresses Colon Cancer Progression by Inhibiting KRT18/MAPK Signaling Pathway

    A biotin-microRNA pull-down assay was performed to identify potential miRNAs. qRT-PCR was used to verify the KRT18 and miR-186-3p levels.
    [Cell Cycle]

    Abstract

    Silencing of Nudix Type 5 Represses Proliferation and Invasion and Enhances Chemosensitivity of Gastric Carcinoma Cells by Affecting the AKT/GSK-3β/β-Catenin Pathway

    A series of cellular functional assays demonstrated that gastric carcinoma cells with silenced NUDT5 exhibited decreased proliferative and invasive ability, increased cell cycle arrest at the G0/G1 phase, and enhanced chemosensitivity.
    [Toxicology and Applied Pharmacology]

    Abstract

    CircRNA_Maml2 Promotes the Proliferation and Migration of Intestinal Epithelial Cells after Severe Burns by Regulating the miR-93-3p/FZD7/Wnt/β-Catenin Pathway

    Overexpression of circRNA_Maml2 promoted the proliferation and migration of CT26 wildtype cells in vivo and the repair of damaged intestinal mucosa in vitro.
    [Burns & Trauma]

    Full Article

    miR-19a Targeting CLCA4 to Regulate the Proliferation, Migration, and Invasion of Colorectal Cancer Cells

    Researchers showed that the level of miR-19a was significantly higher in clinical CRC tissue samples than in paracancerous tissue samples, and significantly higher in CRC cells lines HT29, SW480, and CaCO2 than in the normal human colon mucosal epithelial cell line NCM460.
    [European Journal of Histochemistry]

    Abstract

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    REVIEWS

    Colorectal Liver Metastasis: Molecular Mechanism and Interventional Therapy

    The authors focus on an overview of the recent advances in understanding the molecular basis of colorectal liver metastasis (CRLM) with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
    [Signal Transduction and Targeted Therapy]

    Abstract

    INDUSTRY AND POLICY NEWS

    Aeterna Zentaris Announces Expansion of Research Program with Julius-Maximilians-University Wuerzburg Aiming to Accelerate Development of Vaccine Programs

    Aeterna Zentaris, Inc. announced it has expanded the scope of its existing research program with the Julius-Maximilians-University Wuerzburg, on the development of COVID-19 and Chlamydia trachomatis vaccines.
    [Aeterna Zentaris, Inc.]

    Press Release

    FEATURED EVENT

    EMBO: Microbial Infections and Human Cancer

    April 6 – 9, 2022
    Heidelberg, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Disease Pathogenesis

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    PhD Scientist – Oncology

    University of Virginia School of Medicine – Charlottesville, Virginia, United States

    Postdoctoral Researcher – Intestinal Organoid

    Baylor College of Medicine – Houston, Texas, United States

    Senior Research Scientist II – Therapeutics

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Researcher – Intestinal Organoid

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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