 | | Vol. 8.11 – 25 March, 2022 |
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| Investigators identified Sh2d6 as a signature marker for CD45+ Tuft-2 cells. Depletion of Tuft-2 cells resulted in susceptibility to bacterial infection.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation could be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells.
[Nature Biomedical Engineering] |
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| Researchers reported that pumolio homolog 1 (Pum1) and Pum2 displayed increased expression in human colorectal cancer.
[Nature Communications] |
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| Scientists detected the receptor tyrosine kinase activity in gefitinib-resistant colorectal cancer cells, pan-erb-b2 receptor tyrosine kinase 3 (ErbB3)/EGFR was significantly activated and provided a potential multi-ErbB treatment target.
[Cell Death & Disease] |
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| Transcriptome analysis and self-organizing maps were applied to screen backbone circular RNAs in gastric cancer.
[Cell Death & Disease] |
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| In functional in vitro experiments, researchers observed that calmodulin-binding transcription activator 1 (Camta1) overexpression significantly decreased the proliferation and invasion capacity of SW620 and SW480 cells.
[Cell Death Discovery] |
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| Investigators explored the potential alleviating effects of dietary nano-supplement combined with bacillus strains in a colitis model.
[Scientific Reports] |
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| Chronic colitis models of CagA+ H. pylori-colonized mice treated with 2% Dextran sulphate sodium were established to assess the disease activity and pertinent expression of tight junction proteins closely related to mucosal integrity.
[Gut Pathogens] |
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| Scientists showed that the upregulation of thrombospondin 2 (THBS2) in colorectal cancer (CRC) tissues and CRC cell lines and high expression of THBS2 were correlated with poor overall survival.
[Kaohsiung Journal of Medical Sciences] |
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| A chaperonin containing TCP1 subunit 6A (CCT6A) knockdown colon cancer cell line was established and colony formation, wound healing and Transwell invasion assays were performed to assess proliferation, migration and invasion of the altered colon cancer cells.
[Molecular Medicine Reports] |
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| The authors provide novel insights into the role of chemical chaperone unfolded protein response modulators to modify endoplasmic reticulum (ER) stress levels in the pathogenesis of inflammatory bowel disease.
[Digestive Diseases and Sciences] |
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| Tiziana Life Sciences announced initiation of a Phase Ib clinical trial to evaluate orally administered enteric-coated capsules of foralumab in patients with mild-to-moderate Crohn’s Disease.
[Tiziana Life Sciences Ltd.] |
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| Pfizer, Inc. announced positive topline results from a Phase III study of etrasimod, an investigational, oral, once-a-day, selective sphingosine 1-phosphate receptor modulator in development for the treatment of moderately to severely active ulcerative colitis.
[Pfizer, Inc.] |
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| April 8, 2022 – April 13, 2022
New Orleans, Louisiana, United States |
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| | Princeton University – Princeton, NJ, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, WA, United States |
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| | Cancer Research UK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Columbia University – New York, NY, United States |
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