 | | Vol. 8.14 – 22 April, 2022 |
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| Significantly reduced body β-hydroxybutyrate levels were found in the colonic mucosa from IBD patients and correlated with IBD activity index.
[BMC Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that the expression of farnesoid X receptor (FXR) was negatively correlated with enhancer of zeste homolog 2 (EZH2) in colon cancer tissues.
[Cell Death & Disease] |
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| The authors found a significant positive correlation between C-X-C motif chemokine receptor 7 (CXCR7) expression and cancer-associated fibroblast activation markers in colonic tissues from clinical specimens and in villin–CXCR7 transgenic mice.
[Cell Death & Disease] |
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| Researchers found that auxilin restricted intestinal stem cell proliferation mainly through epidermal growth factor receptor (EGFR) signaling.
[Stem Cell Reports] |
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| Scientists discovered that HECTD3 was abnormally activated in gastric cancer, and the clinical prognosis database suggested that HECTD3 was strongly expressed in gastric cancer.
[Cell Death Discovery] |
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| Investigators suggested that SNORD1C functioned via the Wnt/β-catenin pathway to enhance cancer cell stemness in colorectal cancer and could be a predictive biomarker for the prognosis ad aggressiveness of this malignancy.
[Cell Death Discovery] |
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| Scientists described a complete screening process combining in vitro and in vivo assays in which they conducted a rational selection of a live strain of Christensenella minuta with strong immunomodulatory properties.
[Scientific Reports] |
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| Investigators established a mouse model of acute graft-versus-host disease (aGVHD) to verify whether baicalin could protect the small intestinal mucosal barrier by regulating abnormal autophagy and interfering with intestinal aGVHD.
[Scientific Reports] |
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| Scientists found that cold exposure damaged the morphology and structure of the colon, destroyed the tight junctions of the colonic epithelial tissue, and promoted inflammation of the colon.
[Frontiers in Physiology] |
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| Researchers showed that formate, a metabolite produced by colorectal cancer (CRC)-associated bacterium Fusobacterium nucleatum, promoted CRC development and that microbiome-derived formate drove CRC tumor invasion by triggering aryl hydrocarbon receptor signaling while increasing cancer stemness.
[Nature Metabolism] |
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| The authors discuss how metabolic reprogramming of gastric cancer (GC) cells and immune cells involved in GC immune responses modulate anti-tumor immune responses, as well as the effects of gastrointestinal flora in tumor microenvironment and GC.
[Cell Death & Disease] |
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| Investigators highlight the cellular and molecular interruptions of the gastrointestinal (GI) system due to acute and chronic GI radiation injury, the role of radioprotectors in signaling cascade modulations in GI epithelium and the involvement of intestinal stem cells markers in radioprotection.
[Reviews On Environmental Health] |
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| Processa Pharmaceuticals, Inc. announced that the first patient with advanced, refractory gastrointestinal cancer has been dosed in its amended maximum tolerated dose Phase IB trial for Next Generation Capecitabine.
[Processa Pharmaceuticals, Inc.] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| | The George Washington University – Washington, DC, United States |
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| | TU Dresden – Dresden, Germany |
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| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | Princeton University – Princeton, New Jersey, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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