 | | Vol. 8.15 – 29 April, 2022 |
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| Scientists identified a metabolite signaling pathway that provided actionable insights toward new strategies for its prevention and therapy.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated and reported for the first time that leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) was a key functional downstream factor and therapeutic target for P53 mutation-induced chemoresistance.
[Cell Death & Differentiation] |
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| Investigators found that Helicobacter pylori could induce the upregulation of circMAN1A2 in AGS and BGC823 cells independent of CagA.
[Cell Death & Disease] |
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| The authors reported that JAM-A interacted with NF2 and LATS1, functioning as an initiator of the Hippo signaling pathway, and observed increased YAP activity in JAM-A-deficient intestinal epithelial cells.
[iScience] |
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| The role and underlying mechanism of the Pin1/BRD4 axis in hyperglycemia-induced proliferation and migration of gastric cancer cells were analyzed in vivo and in vitro.
[Cell Death Discovery] |
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| RNA LINC00511, miR-625-5p, and WEE1 levels were tested in colon cancer tissues and cells. Subcellular localization of LINC00511 was clarified.
[Cell Death Discovery] |
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| Scientists showed an intestinal organoid model from pluripotent stem cells with reversed polarity where the apical side faced the surrounding culture media and the basal side faced the lumen.
[Frontiers in Bioengineering and Biotechnology] |
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| Activin A expression was assessed in colorectal cancer (CRC) tissue specimens from 157 patients with primary CRC and the relationship between activin A levels and clinicopathological characteristics were determined.
[Oncology Reports] |
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| Researchers found that co-culture of HT-29 and HCT116 colorectal cell lines with enterotoxigenic Bacteroides fragilis (BF) had a similar effect on activation of IL8 gene and protein expression as treatment with purified BF toxin.
[Gut Pathogens] |
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| Investigators discuss how HER family members were discovered, their functions and roles in cancer, and most importantly, the developmental history and recent updates of therapies targeting HER family members, with colorectal cancer as a focus.
[Critical Reviews in Oncology/Hematology] |
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| The authors summarize the latest research on ferroptosis, its mechanism of action, and its role in the progression of different gastrointestinal tumors.
[Cell Biology International] |
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| Evoke Pharma, Inc. announced that it has been granted new drug product exclusivity by the US FDA for GIMOTI (metoclopramide) nasal spray.
[Evoke Pharma, Inc.] |
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| A Texas A&M team has begun developing an intracavity device that will allow doctors to eliminate leftover cancer cells during surgery, reducing the need for additional treatments such as chemotherapy.
[Texas A&M University College of Engineering] |
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| June 20 – 23, 2022
Sevilla, Spain |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | University of Oxford – Oxford, England, United Kingdom |
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