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| Scientists demonstrated that UHMK1 was frequently upregulated in colorectal cancer samples compared with adjacent normal tissue and high expression of UHMK1 predicted poor outcomes.
[Cell Death & Disease] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors hypothesized that the vertical sleeve gastrectomy-induced increase in enteroendocrine cells was due to changes in intestinal differentiation driven by an increase in bile acid signaling through farnesoid X receptor.
[JCI Insight] |
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| Researchers identified MTG16 as a central mediator of epithelial differentiation, promoting goblet and restraining enteroendocrine cell development in homeostasis and enabling regeneration following dextran sulfate sodium-induced colitis.
[JCI Insight] |
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| The authors found that cardiac glycosides such as ouabain, oleandrin, and digoxin, which are Na+, K+-ATPase inhibitors, decreased the GLUT1 expression in the plasma membrane of human cancer cells.
[Journal of Cellular Physiology] |
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| Investigators generated human jejunal organoid-derived monolayers to determine whether apical nutrient and electrolyte transporter function was regulated by constitutive nitric oxide in human enterocytes.
[Translational Research] |
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| The expression level of serine/arginine-rich splicing factor 9 (SRSF9) was higher in colorectal cancer cell lines than that in an immortal human intestinal epithelial cell line.
[Journal of Translational Medicine] |
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| Scientists proposed a functional serine/arginine-rich splicing factor 3 (SRSF3) inhibitor for colorectal cancer therapy and elucidated its antitumor mechanisms.
[Cell Death Discovery] |
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| miR-17-5p and miR-20a-5p expression was evaluated by in situ hybridization and analyzed using digital pathology. Cell line experiments, using HT-29 and CACO-2, were performed to assess the effect of miR-17-5p and miR-20a-5p.
[Scientific Reports] |
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| Tissue microarrays were used to analyze visfatin differential expression in normal colon and colon cancer tissues, and the data were further validated in vitro.
[International Journal of Oncology] |
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| Tissue biopsies from fibrotic and nonfibrotic intestine of Crohn’s disease (CD)patients, and non-CD patients were obtained; chronic intestinal fibrosis model established by TNBS was treated with antagonist of miR-21; human intestinal epithelial cell, NCM460, were transfected with miR-21 mimics or inhibitor.
[Digestive and Liver Disease] |
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| Researchers found that albendazole induced the subG1 arrest during cell cycle progression, increased the late apoptotic cells, shifted of peak TUNEL-labeled cells peak, and induced apoptosis.
[Biochimie] |
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| Investigators highlight the different mechanisms of ubiquitin-specific peptidase 20 (USP20) in various tumor types and demonstrate that USP20 regulates the stability of multiple proteins.
[Cell Death & Disease] |
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| Non-starch polysaccharides from natural resources, as a type of functional carbohydrates, have a significant therapeutic effect on ulcerative colitis because of their good anti-inflammatory and immunomodulatory activities.
[International Journal of Biological Macromolecules] |
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| Valbiotis announced the first visit of the first patient in the TOTUM•63 mode of action clinical study conducted by the Laval University Institute of Nutrition and Functional Foods (INAF) in Quebec City, in partnership with Nestlé Health Science.
[Valbiotis] |
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| Japanese drug firm Takeda has opened Ireland’s first stem cell therapy manufacturing center at Grange Castle in Dublin.
[The Irish Times] |
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| June 12 – 17, 2022
Newport, Rhode Island, United States |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | University of Glasgow – Glasgow, Scotland, United Kingdom |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | University of Oxford – Oxford, England, United Kingdom |
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