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RNA Splicing Is a Key Mediator of Tumor Cell Plasticity and a Therapeutic Vulnerability in Colorectal Cancer | The authors identified dysregulated RNA splicing as a key driver of tumor cell dedifferentiation in colorectal cancer.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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Antisense Transcription from Lentiviral Gene Targeting Linked to an Integrated Stress Response in Colorectal Cancer Cells | Scientists explored a gene targeting approach to deplete ephrinB2 from colorectal cancer cells using an inducible lentiviral vector.
[Molecular Therapy-Nucleic Acids] |
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HDAC5, Negatively Regulated by miR-148a-3p, Promotes Colon Cancer Cell Migration | To clarify the role of Class IIa Histone deacetylases (HDACs) in the metastasis of colon adenocarcinoma, investigators used the Class IIa HDAC inhibitor TMP269 and found that it effectively inhibited the migration ability of colon adenocarcinoma cells.
[Cancer Science] |
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IFN-α/β-Mediated NK2R Expression Is Related to the Malignancy of Colon Cancer Cells | Researchers found that high neurokinin 2 receptor (NK2R) gene expression was correlated with the poor survival of colorectal cancer patients, and interferon (IFN)-α/β stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a JAK1/2-dependent manner.
[Cancer Science] |
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SFMBT1 Facilitates Colon Cancer Cell Metastasis and Drug Resistance Combined with HMG20A | The role of Scm-like with four malignant brain tumor domains 1 (SFMBT1) in the migration, proliferation and invasion of colorectal cancer or resistance to 5-fluorouracil was determined using scratch assay, colony formation and Transwell assay.
[Cell Death Discovery] |
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The OmpA of Commensal Escherichia coli of CRC Patients Affects Apoptosis of the HCT116 Colon Cancer Cell Line | Scientists analyzed the effect of the outer membrane protein A (OmpA) protein on the expression of the four genes related to apoptosis in the HCT116 colon cancer cell line.
[BMC Microbiology] |
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A Novel Nanobody as Therapeutics Target for EGFR-Positive Colorectal Cancer Therapy: Exploring the Effects of the Nanobody on SW480 Cells Using Proteomics Approach | Researchers determined the effect of cell-penetrable nanobody on cell viability and proteomic profile in epidermal growth factor receptor (EGFR)-positive human colorectal cancer cell lines.
[Proteome Science] |
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ARL2 Is Required for Homologous Recombination Repair and Colon Cancer Stem Cell Survival | ADP-ribosylation factor-like protein 2 (ARL2) was expressed at relatively low levels in K-RAS active colon cancer cells, but its expression was induced in cancer stem cells.
[Febs Open Bio] |
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Apelin-Driven Endothelial Cell Migration Sustains Intestinal Progenitor Cells and Tumor Growth | Scientists report that in colorectal cancer, expansion of the stem/progenitor pool in intestinal crypts required vascular endothelial growth factor A-independent growth and remodeling of blood vessels.
[Nature Cardiovascular Research] |
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Proteomics of Post-translational Modifications in Colorectal Cancer: Discovery of New Biomarkers | The authors discuss the general strategies for proteomic profiling of several key post-translational modifications (PTMs) and summarize the recent applications of these methods to explore the potential roles of the PTMs in colorectal cancer.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis | Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis.
[Surrozen, Inc.] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, Scotland, United Kingdom |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| Stanford University – Palo Alto, California, United States |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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