 | | Vol. 8.21 – 10 June, 2022 |
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| Investigators found that RNF43_p.G659fs promoted cell growth independent of Wnt signaling. PI3K/mTOR inhibitors yielded promising antitumor activity in RNF43659mut isogenic cell lines and xenograft models, as well as in patient-derived organoids harboring RNF43_p.G659fs mutations.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used high-throughput, image-based profiling to quantify phenotypes of over 5 million individual colorectal cancer organoids after treatment with >500 small molecules.
[Nature Communications] |
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| Scientists showed that loss of the tumor suppressor adenomatous polyposis coli, which constituted the initiating event in the adenoma carcinoma sequence for colorectal cancer, induced expression of RNA polymerase I transcription machinery and subsequently upregulated ribosomal DNA transcription.
[Molecular Oncology] |
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| Researchers investigated the effect of egg ovalbumin on survival, cell cycle, self-renewal ability, stemness properties, and migration in SW480 colon cancer cells and 5-fluorouracil resistant subgroup.
[Nutrition and Cancer-An International Journal] |
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| Investigators examined the effect of polymethoxyflavones present in citrus peels on Wnt/β-catenin signaling in the HCT116 colorectal cancer cell line.
[Nutrition and Cancer-An International Journal] |
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| Scientists explored the role of tripartite motif‑containing 22 (TRIM22) in ulcerative colitis and its potential mechanism and revealed that dextran sulphate sodium increased the expression levels of TRIM22 in HT‑29 cells and TRIM30 in mice.
[Molecular Medicine Reports] |
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| A small-molecule RNF31 inhibitor sensitized colon carcinoma organoids to tumor necrosis factor and greatly enhanced bystander killing of MHC antigen-deficient tumor cells.
[Cell Reports Medicine] |
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| Emerging evidence has supported that long non-coding RNAs (lncRNAs) can regulate cell cycle of colorectal cancer (CRC) cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. Investigators summarize the emerging roles of NEAT1 in CRC cells.
[Cancer Cell International] |
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| Zai Lab announced that the EF-31 Phase II pilot study, testing the safety and efficacy of tumor treating fields together with standard-of-care as a first-line treatment in patients with gastric adenocarcinoma, met its primary endpoint of objective response rate with supportive signals across secondary endpoints.
[Zai Lab Limited] |
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| November 10 – 12, 2022
Bordeaux, France
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| | University Hospital of Würzburg – Würzburg, Germany |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Flanders Institute for Biotechnology – Ghent, Belgium |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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