 | | Vol. 8.23 – 24 June, 2022 |
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| A large fraction of polyp and colorectal cancer (CRC) cells exhibited a stem-like phenotype, and investigators defined a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progressed from homeostasis to CRC.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Employing in vivo loss of function and lymphatic:organoid cocultures, researchers showed that crypt lymphatics maintained intestinal stem cells and inhibited their precocious differentiation.
[Cell Stem Cell] |
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| Investigators showed that goblet, Paneth, and enteroendocrine cells arose by multilineage priming in common precursors, followed by selective access at thousands of cell-restricted cis-elements.
[Genes & Development] |
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| A planar, self-renewing human intestinal monolayer platform based on primary adult gastrointestinal stem cells, termed the 2D crypt model, was developed to screen for the effects of various compounds on the intestinal epithelium.
[Analytical Chemistry] |
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| The authors investigated how hederacoside C attenuated intestinal inflammation in vivo and in vitro.
[Acta Pharmacologica Sinica] |
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| Researchers reported that mucinous colorectal carcinoma tumors maintained a robust apico-basolateral polarity as they spread in the peritumoral stroma or organotypic collagen-I gels.
[Journal of Cell Science] |
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| Based on the limited homology between mammalian and avian RSPO1, scientists expected that chicken-derived factors were required for chicken intestinal organoid cultures.
[Scientific Reports] |
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| Tryptophan 2,3-dioxygenase (TDO2) expression was correlated with both progressive disease and clinical outcome, and its expression was an independent predictor of prognosis in gastric cancer.
[Pathobiology] |
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| The authors outline Sperm flagella protein-1 (Spef1)/calponin homology and microtubules-associated protein (CLAMP) structure and expression in several cellular models.
[Annals of the New York Academy of Sciences] |
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| BioKey, ABVC’s wholly owned subsidiary has entered into a Clinical Development Service Agreement with Rgene to guide three Rgene drug products: RGC-1501 for the treatment of non-small cell lung cancer, RGC-1502 for the treatment of pancreatic cancer. and RGC 1503 for the treatment of colorectal cancer patients.
[ABVC Biopharma, Inc. (Globe Newswire, Inc.)] |
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| October 3 – 4, 2022
Keystone Resort, Colorado, United States |
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| | Pennsylvania State University – State College, Pennsylvania, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | European Molecular Biology Laboratory – Heidelberg, Germany |
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| | University Hospital of Würzburg – Würzburg, Germany |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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Cancer Stem Cell News
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