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| Gastric fundic, antral, and duodenal organoids were generated using induced pluripotent stem cell (iPSC) lines from a PDX1188delC/188delC patient and an isogenic iPSC line where the PDX1 point mutation was corrected.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers described bicyclic imidazoliums and guanidines that target the ALDH1B1 active site with comparable molecular interactions and potencies.
[Nature Chemical Biology] |
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| Scientists identified that Lgr4 regulated Lgr5 expression and was required for H. pylori-induced hyperplasia and inflammation, while Lgr5 alone was not.
[EMBO Journal] |
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| Colorectal cancer patient samples and samples from AOM/DSS treated mice were analyzed for expression of IL-9, CD3 and PU.1 by FACS analysis and immunohistochemistry.
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| Researchers investigated the effect of garcinone C on cancer stemness and invasiveness in colorectal cancer; Gli1 was noted as pivotal in maintaining stemness and invasiveness in HCT116 and HT29 cancer stem cells.
[Journal of Agricultural and Food Chemistry] |
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| Investigators found carbohydrate response element binding protein (CHREBP) downregulation in gastric cancer (GC) tissues, and CHREBP was determined to be an independent diagnostic marker of GC.
[Cell Death Discovery] |
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| Scientists discovered that hypoxia-induced oxaliplatin resistance and HOX transcript antisense RNA (HOTAIR) expression was increased in hypoxia-treated colorectal cancer (CRC) cell lines and CRC tumors.
[Cell Death Discovery] |
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| SW480 and HCT116 cells were treated with neogambogic acid at different concentrations and transfected with siDLK1 and pcDNA3.1-DLK1 plasmids.
[European Journal of Pharmacology] |
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| Patient-derived organoids expand from highly proliferative LGR5+ tumor cells; however, investigators discovered that the lack of optimal growth conditions specified a latent LGR5+ cell state.
[Nature Cancer] |
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| The authors focus on reviewing the structure, sources and specific applications of various functional oligosaccharides related to the prevention and treatment of ulcerative colitis.
[Food & Function] |
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| After launching its first liquid biopsy service in Europe earlier this year, the cancer test developer Guardant Health has taken new steps to offer its comprehensive genomic profiling technology in China.
[Fierce Biotech] |
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| | University of Twente – Enschede, Netherlands |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Tampere University – Tampere, Finland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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