Intestinal Cell News Volume 8.26 | Jul 22 2022

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    2022-07-22 | ICN 8.26


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.26 – 22 July, 2022
    TOP STORY

    SMAD4 Suppresses Colitis-Associated Carcinoma through Inhibition of CCL20/CCR6-Mediated Inflammation

    Scientists examined the role of the chemokine/receptor pair CCL20/CCR6 in mediating colitis-associated colon carcinogenesis induced by SMAD4 loss.
    [Gastroenterology]

    AbstractPress Release
    Webinar: The Promise of Organoid Medicine
    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal-Epithelial Interaction Regulates Gastrointestinal Tract Development in Mouse Embryos

    Using gut tube-derived organoids, researchers found that the cell fate of the foregut and hindgut could be switched by the regional niche factors, including fibroblast growth factors and retinoic acid.
    [Cell Reports]

    Full ArticleGraphical Abstract

    KIT Promotes Tumor Stroma Formation and Counteracts Tumor-Suppressive TGFβ Signaling in Colorectal Cancer

    Investigators employed genome-editing technologies in patient-derived organoids to study receptor tyrosine kinase KIT function in colorectal cancer in vitro and in vivo.
    [Cell Death & Disease]

    Full Article

    Multifocal Organoids Reveal Clonal Associations between Synchronous Intestinal Tumors with Pervasive Heterogeneous Drug Responses

    Researchers reported one unique case of synchronous intestinal cancer with tumors occurring along the entire bowel tract, including the small intestine.
    [NPJ Genomic Medicine]

    Full Article

    Chemoproteomics Reveals Berberine Directly Binds to PKM2 to Inhibit the Progression of Colorectal Cancer

    The chemical proteomics method was used and demonstrated that berberine directly bound to pyruvate kinase isozyme type M2 (PKM2) in colorectal cancer cells.
    [iScience]

    Full ArticleGraphical Abstract

    Establishment of Patient-Derived Gastric Cancer Organoid Model From Tissue Obtained by Endoscopic Biopsies

    Investigators established gastric cancer patient-derived organoids from tissues obtained by endoscopic biopsies.
    [Journal of Korean Medical Science]

    Full ArticleGraphical Abstract
    Five tips for returning to the lab after time off
    REVIEWS

    Aging and Rejuvenation of Tissue Stem Cells and Their Niches

    The authors discuss cellular and molecular mechanisms underlying aging in the regenerative regions of different tissues as well as potential rejuvenation strategies.
    [Nature Reviews Molecular Cell Biology]

    Abstract

    The Hippo–YAP/TAZ Signaling Pathway in Intestinal Self-Renewal and Regeneration After Injury

    Investigators summarize the roles of YAP/TAZ in the phases of intestinal self-renewal and regeneration to suggest a potential strategy for IBD treatment.
    [Frontiers in Cell and Developmental Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Prometheus Biosciences Completes Enrollment of the ARTEMIS-UC Cohort 1 Phase II Study in Ulcerative Colitis

    Prometheus Biosciences, Inc. announced the completion of enrollment for Cohort 1 of the ARTEMIS-UC global Phase II study of PRA023 in ulcerative colitis.
    [Prometheus Biosciences, Inc.]

    Press Release
    FEATURED EVENT

    Advances in Therapeutic Applications of Stem Cells

    December 8 – 10, 2022
    Los Angeles, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Postdoctoral Scholar – Department of Physiology

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Postdoctoral Fellow – Alcohol-Related Injury

    University of North Carolina at Greensboro – Kannapolis, North Carolina, United States

    Postdoctoral Training Fellow – Intestinal Stem Cell

    Francis Crick Institute – London, England, United Kingdom

    Junior Professor – Experimental Gastroenterology

    University Hospital Aachen – Aachen, Germany

    > See All Jobs

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