 | | Vol. 8.27 – 29 July, 2022 |
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| The authors showed factors which promoted EGFR-dependent metabolic changes that increased intestinal stem cell mass, mitochondrial growth, and mitochondrial activity.
[Current Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The abundance of hypoxic and normoxic cancer stem cells (CSCs) were analyzed in primary colorectal cancer tumors. It was found that the proportion of normoxic CSCs were positively associated with tumor stage.
[Cell Death & Disease] |
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| Researchers reported a method for simple, reproducible, and scalable production of small intestinal organoids based on the aggregation of cryopreservable human pluripotent stem cell (hPSC)-derived mid-hindgut endoderm monolayers.
[Stem Cell Reports] |
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| Orthotopic HT29 with intact vascular endothelial growth factor-A (VEGF-A) gene and VEGF-A knockdown HT29 colon cancer-bearing mice were treated with specific Y2 receptor antagonists, and the effects on angiogenesis and tumour growth were studied.
[British Journal of Cancer] |
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| The authors explored the function and mechanism of mesenchymal stem cell-transformed cancer associated fibroblast cells (MT-CAFs) on the progression of colon cancer.
[Stem Cell Research & Therapy] |
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| Scientists investigated the expression and role of Sirtuin1 or Silent mating–type information regulation 2 homolog-1 in post-necrotizing enterocolitis stricture.
[Frontiers in Pediatrics] |
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| Investigators discuss recent insights from complementary model systems into the force-dependent mechanisms that establish and maintain the unique architecture of the intestine.
[Current Biology] |
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| Clarkson University Biology Professor Kenneth Wallace was recently awarded a $429,000 grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development at the National Institute of Health (NIH) to investigate the development of intestinal stem cells using the zebrafish vertebrate model system.
[Clarkson University] |
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| November 7 – 8, 2022
London, England, United Kingdom |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | City of Hope – Duarte, California, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of North Carolina at Greensboro – Kannapolis, North Carolina, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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