Intestinal Cell News Volume 8.28 | Aug 5 2022

    By
    Bob
    -
    0
    19








    2022-08-05 | ICN 8.28


    Intestinal Cell News by STEMCELL Technologies
    Vol. 8.28 – 5 August, 2022
    TOP STORY

    Ribosome Impairment Regulates Intestinal Stem Cell Identity via ZAKɑ Activation

    Using intestinal organoids and mouse models, scientists showed that upon ribosome impairment, driven by Rptor deletion, amino acid starvation, or low dose cyclohexamide treatment, intestinal stem cells gained an Lgr5-negative, fetal-like identity.
    [Nature Communications]

    Full Article
    View tips on how to organize your lab bench space.
    PUBLICATIONSRanked by the impact factor of the journal

    Cholesterol Sulfate Alleviates Ulcerative Colitis by Promoting Cholesterol Biosynthesis in Colonic Epithelial Cells

    The authors studied the functional role and underlying intestinal epithelial repair mechanisms of cholesterol sulfate in ulcerative colitis.
    [Nature Communications]

    Full Article

    N6-Adenomethylation of GsdmC Is Essential for Lgr5+ Stem Cell Survival to Maintain Normal Colonic Epithelial Morphogenesis

    Mettl14 ablation triggered apoptosis that depleted Lgr5+ stem cells and disrupted colonic organoid growth and differentiation, whereas the inhibition of apoptosis rescued Mettl14-deleted mice and organoids.
    [Developmental Cell]

    AbstractGraphical Abstract

    Intestinal Epithelial Responses to IL-17 in Adult Stem Cells-Derived Human Intestinal Organoids

    Investigators found that organoid-forming efficiency, cell viability, and proliferation of enteroids were decreased in proportion to interleukin-17A (IL-17) concentration.
    [Journal of Crohn’s and Colitis]

    AbstractGraphical Abstract

    An Analysis of the Significance of the Tre2/Bub2/CDC 16 (TBC) Domain Protein Family 8 in Colorectal Cancer

    Researchers identified the role of TBC1 domain family member 8 (TBC1D8) as an oncogene in colorectal cancer (CRC) showing that TBC1D8 may independently predict CRC outcome.
    [Scientific Reports]

    Full Article

    Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer

    Scientists revealed that ubenimex and/or celecoxib exerted anti–colon cancer effects in vitro and in vivo, and the efficacy was significantly enhanced when the two drugs were combined.
    [Journal of Pharmacology and Experimental Therapeutics]

    Abstract
    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    The Metabolic Nature of Inflammatory Bowel Diseases

    The authors review experimental and clinical evidence for the metabolic nature of gut inflammation in IBD and delineate distinct parallels to the inflammatory state in metabolic diseases.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    InterVenn Biosciences Announces Start of Enrollment in Colonoscopy Study

    InterVenn® Biosciences announced the start of enrollment in its prospective cohort study for early detection of colorectal cancer and adenomas.
    [InterVenn® Biosciences (Business Wire, Inc.)]

    Press Release
    FEATURED EVENT

    Diet, Nutrition and Cancer Cell Metabolism

    October 24 – 26, 2022
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Liver Injury

    University of Kansas Medical Center – Kansas City, Kansas, United States

    PhD Student – Bioinformatics

    German Cancer Research Center in the Helmholtz Association – Dresden, Germany

    Doctoral Students – Regeneration of Insulin-Producing Beta-Cells

    Karolinska Intitutet – Stockholm, Sweden

    Data Scientist – 3D Imaging of High-Content Screening Experiments

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Staff Scientist – Genomic and Epigenomics of Gastrointestinal Cancers

    City of Hope – Duarte, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Intestinal Cell News Twitter