Mammary Cell News 10.09 March 8, 2018 | |
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TOP STORYInvestigators found that JNK was required for efficient involution. JNK deficiency did not alter the STAT3/5 or SMAD2/3 signaling pathways that have been previously implicated in this process. [Cell Death Differ] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Post-Translational Modification of OCT4 in Breast Cancer Tumorigenesis Researchers generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich cancer stem cells (CSCs) and performed DNA microarray analysis. They found that the expression of carboxy terminus of HSP70-interacting protein E3 ubiquitin ligase was significantly downregulated in breast CSCs. [Cell Death Differ] Full Article miR-190 down-regulation was required for transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition. miR-190 suppressed breast cancer metastasis both in vitro and in vivo by targeting SMAD2. [Mol Cancer] Full Article Scientists investigated the effects of raddeanin A (RA) in breast cancer-induced osteolysis and elucidated the possible mechanisms involved in this process. They verified that RA could suppress osteoclast formation and bone resorption in vitro. [Cell Death Dis] Full Article Metformin-Induced Caveolin-1 Expression Promotes T-DM1 Drug Efficacy in Breast Cancer Cells BT-474 cells were pretreated with metformin, followed by combined therapy with metformin and trastuzumab emtansine (T-DM1). The T-DM1 internalization and drug efficacy were determined, and the protein expressions for signal transduction were also monitored. [Sci Rep] Full Article The effect of SESN2 on amino acids (AA)-mediated cell proliferation and casein synthesis in cow mammary epithelial cells (CMECs) was assessed. After 12 hours of AA starvation, CMECs were cultured in the absence of all AA, in the presences of only essential AA, or of all AA. [Sci Rep] Full Article BCSC-1 Suppresses Human Breast Cancer Metastasis by Inhibiting NF-κB Signaling Breast cancer suppressor candidate-1 (BCSC-1) gene expression was evaluated in different breast cancer cell lines by quantitative polymerase chain reaction and the MDA-MB-231 cell line was selected for further use in subsequent experiments, due to its low BCSC-1 expression. [Int J Oncol] Abstract Scientists investigated the biochemical properties of TPO expressed in normal and cancerous human breast tissues, and the maturation process and antigenicity of TPO present in a panel of human breast tissue-derived cell lines. [PLoS One] Full Article Cell viability and migration of breast cancer cells was determined using MTS assays and wound healing assays, respectively. RNA-Seq analysis of breast tumors and qPCR in breast cancer cell lines were used to assess mRNA levels of ion channels. [Life Sci] Abstract | |
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REVIEWSBET Proteins in Abnormal Metabolism, Inflammation, and the Breast Cancer Microenvironment The somatic BET proteins, comprising BRD2, BRD3, and BRD4, are new critical regulators of metabolism, coactivate transcription of genes that encode proinflammatory cytokines in immune cell subsets infiltrating the microenvironment, and could be important targets in breast cancer immunotherapy. [J Leukoc Biol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSThe Cell and Gene Therapy Catapult (CGT Catapult) announced it has signed a Memorandum of Understanding with the Japanese Society for Regenerative Medicine (JSRM). This agreement between the CGT Catapult and JSRM aims to advance regenerative medicine and cell and gene therapies in both the UK and Japan. [The Cell and Gene Therapy Catapult] Press Release For the third year in a row, donors can have their breast cancer donations and impact doubled thanks to the Milburn Foundation, Inflammatory Breast Cancer Research Foundation, and Susan G. Komen®. [Milburn Foundation (Business Wire, Inc.)] Press Release | |
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POLICY NEWSRise of Nationalist and Populist Parties Has Italian Scientists Worried The outcome of parliamentary elections in Italy was a stunning victory for populist and nationalist parties, and a clear warning to Italy’s political establishment and the European Union. But some in Italy worry that the results may also have a negative impact on science. [ScienceInsider] Editorial What Researchers Can Expect from China’s Top-Level Political Meetings As Chinese leaders gather for the government’s most significant meetings of the year, researchers are anticipating major policy announcements for science and innovation that could shape the country’s research agenda for years. [Nature News] Editorial New NSF Rules on Sexual Harassment Leave Many Questions Unanswered The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial
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EVENTSNEW Cold Spring Harbor (CSH): Mechanisms & Models of Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Graduate Student – Breast and Colorectal Cancer (Dalhousie University) NEW Postdoctoral Researcher – Breast Cancer Biology (Karolinska Institutet) Higher Scientific Officer – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Researcher – Genomic Breast Cancer Epidemiology (Karolinska Institutet) Computational Biologist – Cancer Research (Cancer Research UK Manchester Institute) Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science) Cancer Bioinformatician – Breast Cancer Research (The Institute of Cancer Research) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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