Mammary Cell News 10.11 March 22, 2018 | |
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TOP STORYResearchers established novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived cancer stem cell-enriched brain metastasis tumorsphere cells into mice. [Cancer Res] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators identified KIBRA as a major factor contributing to the effects of 5q loss on tumor growth and metastatic progression. Re-expression of KIBRA impaired metastasis in vivo and inhibited tumorsphere formation by triple-negative breast cancer cells in vitro. [Cell Rep] Full Article | Graphical Abstract Investigators found that liver receptor homolog-1 (LRH1) levels were significantly elevated in primary breast cancer tissues in patients who developed early recurrence. Similarly, adriamycin-resistant breast cancer cell lines also exerted high LRH1 expression. [Oncogene] Abstract Transmembrane TNF-Alpha Promotes Chemoresistance in Breast Cancer Cells Alteration of tumor necrosis factor-α (tmTNF-α) expression changed the sensitivity of primary human breast cancer cells and breast cancer cell lines to doxorubicin (DOX). Overexpression of N-terminal fragment of tmTNF-α, a mutant form with intact intracellular domain of tmTNF-α to transmit reverse signals, induced DOX-resistance. [Oncogene] Abstract Upon knock-down of semaphorin 4C (Sema4C) or its receptor PlexinB2 in diverse mammary carcinoma cells, scientists observed dramatic growth inhibition associated with impairment of G2/M phase transition, cytokinesis defects and the onset of cell senescence. [Cell Death Differ] Abstract Functional studies revealed that blocking the FOXP3/Gal-1 interaction restores the tumor-suppressive properties of FOXP3 in breast cancer cells. [Cell Death Dis] Full Article MICAL1 Facilitates Breast Cancer Cell Proliferation via ROS-Sensitive ERK/Cyclin D Pathway Researchers showed that molecule interacting with CasL 1 (MICAL1) modulates reactive oxygen species (ROS) production, and the latter then activates phosphatidyl inositol 3-kinase/protein kinase B signaling pathway which regulates breast cancer cell invasion. [J Cell Mol Med] Abstract Scientists found that the pan-caspase inhibitor zVAD-fmk failed to inhibit bufalin-induced cell death in MCF-7 and MDA-MB-231 human breast cancer cells, confirming that the cell death induced by bufalin is caspase-independent. [Carcinogenesis] Abstract Researchers showed that in sparsely plated 4T1 cells, E-cadherin levels are moderately reduced, leading to the development of collective migration, whereby cells translocate in loose clusters, interconnected by thin membrane tethers. [Sci Rep] Abstract miR-144 was down-regulated in breast cancerous tissues and cells, whereas CEP55 expression was up-regulated in breast cancerous tissues. There existed a target relationship between miR-144 and CEP55 and negative correlation on their expressions. [Cancer Biol Ther] Abstract The authors established a Src inhibitor saracatinib-resistant breast cancer cell line for the first time. Microarray data and qRT-PCR results showed that miR-19b-3p expression was downregulated in saracatinib-resistant cells compared with saracatinib-sensitive cells. [Arch Biochem Biophys] Abstract Scientists observed that miR-424-5p expression was decreased in basal-like breast cancer tissues and cell lines. They found 3’-UTR of doublecortin like kinase 1 (DCLK1) had binding site of miR-424-5p based on microRNA target databases, and there was an inverse correlation between miR-424-5p and DCLK1 in basal-like breast cancer tissues. [Biomed Pharmacother] Abstract Investigators showed that X inactive specific transcript (XIST) was significantly down-regulated in breast cancer tissues and cell lines. Further functional analysis indicated that overexpression of XIST remarkably inhibited breast cancer cell growth, migration, and invasion. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSNon-Angiogenic Tumors and Their Influence on Cancer Biology Non-angiogenic tumor growth has now been observed in tumors of many different organs in both humans and preclinical animal models. The authors summarize how these tumors were discovered and discuss what we know so far about their biology and the potential implications of this knowledge for cancer treatment. [Nat Rev Cancer] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSIn BRCA Mutation Carriers, Obesity Is Linked with Increased DNA Damage in Normal Breast Gland Cells Being obese or having a higher body mass index while carrying a BRCA mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests. [Press release from the Endocrine Society (Newswise, Inc) discussing research presented at ENDO 2018, the 100th annual meeting of the Endocrine Society, Chicago] Press Release | Abstract | |
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INDUSTRY NEWSMerus N.V. and the Vall d’Hebron Institute of Oncology announced a strategic research collaboration to develop novel agents for therapeutic applications. [Merus N.V.] Press Release Comprehensive Breast Health Center Expands at UC San Diego Health With a diagnosis of breast cancer, everything changes. The calendar becomes filled with scheduled tests and scans, perhaps daily infusions or weekly visits with medical and surgical experts. Depending on the type and stage of cancer, treatment can last months or years. To make the experience significantly easier for patients, UC San Diego Health has designed a state-of-the-art space to bring all team members and services into one convenient location. [UC San Diego Health] Press Release | |
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POLICY NEWSUS Science Agencies Set to Win Big in Budget Deal Nearly all US science agencies would see their budgets grow in 2018, under a US$1.3-trillion spending deal announced. For the second year in a row, lawmakers in Congress seem set to ignore the steep cuts sought by President Donald Trump. [Nature News] Editorial Expectations Are High for UKRI, the United Kingdom’s New £6 Billion Research Behemoth Combine U.S. agencies akin to the National Institutes of Health, National Science Foundation, and National Endowment for the Humanities. Toss in some energy and innovation research and fuel it all with the largest boost in R&D spending in recent history. Then put one person in charge. [ScienceInsider] Editorial HIV Researcher Is New Head of US Public-Health Agency HIV researcher Robert Redfield will lead the Centers for Disease Control and Prevention, Secretary of Health and Human Services Alex Azar announced. [Nature News] Editorial Chinese Leaders Create Super Science Ministry Chinese leaders released plans to expand the powers of the country’s science and technology ministry. The beefed-up agency will continue to oversee science policy and major projects, but will take on extra responsibilities for funding research grants and for recruiting foreign scientists. [Nature News] Editorial
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EVENTSNEW Goodbye Flat Biology: In Vivo Inspired Cancer Biology and Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Breast Cancer (UT Southwestern Medical Center) NEW Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine) NEW Postdoctoral Training Fellow – Endocrinology (Institute of Cancer Research) NEW Staff Position – Breast Cancer Tumor Immunology (Cleveland Clinic Taussig Cancer Institute) NEW Research Fellow – Breast Cancer (Dana-Farber Cancer Institute) Postdoctoral Researcher – Cancer and RNA Biology (University of Texas) Tenure-Track Faculty Position – Pathology (McGill University) Graduate Student – Breast and Colorectal Cancer (Dalhousie University) Higher Scientific Officer – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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