Mammary Cell News Volume 10.23 | Jun 14 2018

TOP STORY

Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF-1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment

Chemotherapy increased DUSP9 expression and decreased DUSP16 expression in a hypoxia-inducible factor (HIF)-1-dependent manner, leading to inhibition of ERK and activation of p38 signaling pathways, respectively. Inhibition of HIF-1 or p38 signaling blocked chemotherapy-induced pluripotency factor expression and breast cancer stem cells enrichment. [Cancer Res] Abstract

(Ranked by impact factor of the journal)

TRPS1 Regulates Oestrogen Receptor Binding and Histone Acetylation at Enhancers

By exploiting a focused siRNA screen that investigated the requirement for a library of 330 chromatin regulators in estrogen receptor alpha-mediated cell growth, researchers found that the NuRD and coREST histone deacetylation complexes are critical for breast cancer cell proliferation. [Oncogene] Abstract

The Iron Chelator Deferasirox Synergizes with Chemotherapy to Treat Triple Negative Breast Cancers

The combination of deferasirox with doxorubicin and cyclophosphamide delayed recurrences in breast cancer patient-derived xenografts without increasing the side-effects of chemotherapies alone or altering global iron storage of mice. [J Pathol] Abstract

Antitumor Activity of Nanoliposomes Encapsulating the Novobiocin Analogue 6BrCaQ in a Triple-Negative Breast Cancer Model in Mice

Scientists investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. They investigated the anti-proliferative effects of this drug in vivo in an orthotopic breast cancer model using pegylated liposomes to allow its administration. [Cancer Lett] Abstract

Cooperative Multi-Targeting of Signaling Networks by angiomiR-204 Inhibits Vasculogenic Mimicry in Breast Cancer Cells

Ectopic restoration of miR-204 in MDA-MB-231 cells leads to a potent inhibition of vasculogenic mimicry and reduction of number of branch points and patterned 3D channels. Mechanistic studies confirmed that miR-204 exerts a negative post-transcriptional regulation of PI3K-α and c-SRC proto-oncogenes. [Cancer Lett] Abstract

Pharmacological Inactivation of the PI3K p110δ Prevents Breast Tumour Progression by Targeting Cancer Cells and Macrophages

Pharmacological inactivation of p110δ in mice with defective macrophages or in mice with normal macrophages but grafted with p110δ-lacking tumors suppressed only partly tumor growth, indicating a requisite role of p110δ in both macrophages and cancer cells in tumor progression. [Cell Death Dis] Full Article

Targeting Tumor Re-Wiring by Triple Blockade of mTORC1, Epidermal Growth Factor, and Oestrogen Receptor Signaling Pathways in Endocrine-Resistant Breast Cancer

A panel of estrogen receptor-positive breast cancer cell lines adapted to long-term estrogen deprivation and expressing ESR1 ^wt or ESR1 ^Y537S , modeling acquired resistance to an aromatase-inhibitor, were treated in vitro with a combination of RAD001 and neratinib in the presence or absence of estradiol, tamoxifen, or fulvestrant. [Breast Cancer Res] Full Article

Interleukin-6/STAT3 Signaling Regulates Adipocyte Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells

Blocking of interleukin-6 signaling in breast cancer cells and adipocytes decreased proliferation, migration and invasion capabilities and altered the expression of genes regulating epithelial-mesenchymal transition. [Sci Rep] Full Article

Therapeutic Positioning of Secretory Acetylated APE1/Ref-1 Requirement for Suppression of Tumor Growth in Triple-Negative Breast Cancer In Vivo

Hyperacetylation in the triple-negative breast cancer xenografts induced strong inhibition of tumor growth and development, leading to apoptotic cell death, accompanied by increased receptor for advanced glycation end products expression and generation of reactive oxygen species. [Sci Rep] Full Article

A Ternary Mixture of Common Chemicals Perturbs Benign Human Breast Epithelial Cells More Than the Same Chemicals Do Individually

Investigators studied the effects of a ternary mixture of bisphenol-A, methylparaben, and perfluorooctanoic acid on benign breast epithelial cells at the range of concentrations observed for single chemicals in human samples. [Toxicol Sci] Full Article

Lack of Acquired Resistance in HER2-Positive Breast Cancer Cells after Long-Term HER2 siRNA Nanoparticle Treatment

Scientists developed a therapeutic HER2 siRNA delivered using mesoporous silica nanoparticles modified with polymers and conjugated with HER2 targeting antibodies. HER2 ablation with HER2 siRNA prevented reactivation of HER2 signaling that was observed in cells resistant to lapatinib. [PLoS One] Full Article

Down-Regulation of NAMPT Expression by mir-206 Reduces Cell Survival of Breast Cancer Cells

miR-206 reduced nicotinamide phosphoribosyltransferase (NAMPT) expression at the protein level, leading to a significant decrease in the intracellular nicotinamide adenine dinucleotide level and subsequent decline in cell survival and induction of apoptosis. [Gene] Abstract

The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

Investigators examine the multifaceted role of signal transducer and activator of transcription 3 (STAT3) in mammary gland involution and tumorigenesis, incorporating a review of these fundamental processes in tandem with a discussion of recent developments in this field. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

Tyme Releases Detailed Data and Analyses with SM-88 from the First Human Study and Compassionate Use Programs

Tyme Technologies, Inc. release detailed patient data and analyses from both the First Human Study and Compassionate Use Program of SM-88 in metastatic cancer patients following the completion of review of all available data by blinded radiologists. [Tyme Technologies, Inc.] Press Release

Arcus Biosciences Announces FDA Clearance of INDs for AB928 and AB122 and Initiation of Phase I/Ib Program to Evaluate AB928 Combinations

Arcus Biosciences, Inc. announced that the FDA has cleared Investigational New Drug (IND) applications for the company’s two most advanced product candidates, AB928 and AB122. Clearance of the first IND for AB928 allows the company to proceed with its planned Phase I/Ib trial to evaluate the safety, tolerability and preliminary efficacy of AB928 in combination with other agents, including AB122 and chemotherapy, in patients with breast and gynecologic malignancies. [Arcus Biosciences, Inc.] Press Release

Sexual Harassment Is Rife in the Sciences, Finds Landmark US Study

Sexual harassment is pervasive throughout academic science in the United States, driving talented researchers out of the field and harming others’ careers, finds a report from the US National Academies of Sciences, Engineering, and Medicine in Washington DC. The analysis concludes that policies to fight the problem are ineffective because they are set up to protect institutions, not victims — and that universities, funding agencies, scientific societies and other organizations must take stronger action. [Nature News] Editorial

North American Universities Increasingly Cancel Publisher Packages

Florida State University (FSU) will head into negotiations with the publisher Elsevier to see how it can resolve a pricing issue. Back in April, FSU announced that it would not renew a so-called “big deal” with Elsevier in 2019, due to its “high and ever-increasing cost,” and would instead subscribe to a subset of the most-needed journals. The university’s move represents the latest example of academic libraries walking away from these comprehensive and expensive subscriptions, which include all or most of a publisher’s catalog, and instead signing up for a la carte titles. [The Scientist] Editorial

PM Jacinda Ardern Announces New Science Advisor

Prime Minister Jacinda Ardern has appointed an Auckland biochemist expert as her new Chief Science Advisor. Professor Juliet Gerrard will replace outgoing advisor professor Sir Peter Gluckman, Ardern announced on Tuesday at the University of Auckland. [Stuff Limited] Editorial

NEW Joint Dutch German Vascular Biology Meeting
November 21-23, 2018
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Post-doctoral Fellow – Ovarian and Breast Cancers (John Hopkins University)

Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University Feinberg School of Medicine)

Postdoctoral Research Associate – Breast Cancer (Howard University)

Postdoctoral Fellow – Breast & Ovarian Cancer Genomics (University of Texas Health Science Center at Houston)

Cancer Scientists – Breast Cancer Research (Qatar Biomedical Research Institute)

Postdoctoral Position – Ovarian and Breast Cancer Research (Indiana University School of Medicine)

Postdoctoral Position – Breast Cancer Research (Northwestern University)

Postdoctoral Posion – Basic & Translational Breast Cancer Research (Northwestern University)

Postdoctoral Positions – Translational Bioinformatics or Molecular Cancer Biology (University of Pittsburgh Cancer Institute)

Postdoctoral Research Fellow – Translational Mitochondrial Research (Fred Hutch Cancer Research Center)

Postdoctoral Position – Breast Cancer Research (Rutgers Cancer Institute of New Jersey)

Graduate Student – Breast and Colorectal Cancer (Dalhousie University)

Postdoctoral Fellows – Breast Cancer Stem Cell Research (New York University School of Medicine)

Postdoctoral Fellow or Research Scientist – Breast Cancer Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellowship – Cancer Research (Mass General Hospital/Harvard Medical School)

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