Mammary Cell News 10.31 August 9, 2018 | |
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TOP STORYTRPS1 Shapes YAP/TEAD-Dependent Transcription in Breast Cancer Cells Investigators showed that trichorhinophalangeal syndrome 1 (TRPS1) globally regulated yes-associated protein (YAP)-dependent transcription by binding to a large set of joint genomic sites, mainly enhancers. Loss of TRPS1 led to activation of enhancers due to increased H3K27 acetylation and an altered promoter-enhancer interaction landscape. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Plk1 Overexpression Induces Chromosomal Instability and Suppresses Tumor Development Using a new inducible knock-in mouse model scientists reported that polo-like kinase 1 (Plk1) overexpression resulted in abnormal chromosome segregation and cytokinesis, generating polyploid cells with reduced proliferative potential. In vivo, Plk1 overexpression prevented the development of Kras-induced and Her2-induced mammary gland tumors, in the presence of increased rates of chromosome instability. [Nat Commun] Full Article | Press Release Researchers showed that deletion of Suz12, a core component of all polycomb repressive complex 2 (PRC2) complexes, resulted in loss of H3K27me3 and H3K27me2 dimethylation, completely blocked normal mammary gland development, and profoundly curtailed progenitor activity in 3D organoid cultures. [PLoS Biol] Full Article Fetal mammary stem cells showed balanced co-expression of factors associated with discrete adult lineages and a metabolic gene signature that subsides during maturation but reemerges in some human breast cancers and metastases. [Cell Rep] Full Article | Press Release | Graphical Abstract Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer Scientists examined multiple estrogen receptor alpha gene (ESR1) fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. Both fusions activated a metastasis-associated transcriptional program, induced cellular motility, and promoted the development of lung metastasis. [Cell Rep] Full Article | Press Release | Graphical Abstract The authors reported that the Rho GTPase activators Vav2 and Vav3 utilize a new Rac1-dependent and miR-200c-dependent mechanism that maintained the epithelial state by limiting the abundance of the Zeb2 transcriptional repressor in breast cancer cells. [Oncogene] Full Article Investigators found functional penetrating ‘Phylomer’ peptide (FPPa)-dominant-negative MYC peptide (OmoMYC) to be a potent inducer of apoptosis in triple-negative breast cancer cells with negligible effects in non-tumorigenic cells. [Oncogene] Full Article The authors generated a HER2-3’untranslated region (UTR) expressing vector to test the tumor-promoting properties in HER2 low expressing T47D and MCF7 cells. The HER2 3’UTR pronouncedly promoted cell proliferation, colony formation, and breast tumor growth. High-throughput sequencing revealed a significant increase in HER3 mRNA and protein levels by the HER2 3’UTR. [Mol Cancer] Full Article Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor Researchers showed that breast cancer stem cells (BCSCs) sorted from pre-malignant breast cancer cells exhibited decreased RUNX1 levels, while ectopic expression of RUNX1 suppressed tumorsphere formation and reduced the BCSC population. RUNX1 functioned to suppress breast cancer tumor growth through repression of cancer stem cell activity and direct inhibition of Zeb1 expression. [Mol Cancer Res] Abstract The forced expression of miR-191 or miR-425 stimulated the proliferation, survival, migration and invasion of breast cancer cells, while the inhibition of miR-191 or miR-425 suppressed these oncogenic behaviors of breast cancer cells, in a manner dependent on miR-191/425-mediated downregulation of DICER1. [Carcinogenesis] Abstract Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSAdvances in Targeting Epidermal Growth Factor Receptor Signaling Pathway in Mammary Cancer The authors highlight the importance of targeting epidermal growth factor receptor signaling pathway in terms of its crosstalk with estrogen receptors, the involvement of extracellular matrix effectors and epigenetics. [Cell Signal] Abstract | Graphical Abstract Functional Implications of Rab27 GTPases in Cancer The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. Investigators discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. [Cell Commun Signal] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSContext Therapeutics, announced it has signed multiple research collaborations to further understand the role of progesterone receptor signaling and its blockade to overcome resistance mechanisms underlying metastatic breast cancer. [Context Therapeutics] Press Release The grant will provide up to $2.3 million in funding for preclinical studies, cGMP manufacturing and a nonclinical toxicology study that will enable an investigational new drug application (IND) submission for Agilvax’s lead immunotherapy product, AX09. [Agilvax] Press Release Scientist Receives Grant for Cancer Metastasis Research To continue research on the use of chemical approaches to better understand cancer progression and to develop novel anti-cancer therapeutic agents, Gregg B. Fields, Ph.D., director of the Center for Molecular Biology and Biotechnology in FAU’s Charles E. Schmidt College of Science, received a three-year grant of $708,044 from the Florida Department of Health’s James and Esther King Biomedical Research Program. [Florida Atlantic University] Press Release | |
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POLICY NEWSJapanese Medical University Admits to Discriminating against Female Applicants A prominent Japanese medical university said that school administrators have deliberately manipulated entrance exam scores to limit the number of women admitted. The confession helps explain the lopsided gender ratio of graduates from Tokyo Medical University and strengthens suspicions that similar practices have prevailed at other Japanese medical schools. [ScienceInsider] Editorial Top US Biomedical Institute Settles Gender-Discrimination Lawsuits The Salk Institute has reached a deal with two of three female scientists who alleged unequal treatment. Cancer researchers Katherine Jones and Victoria Lundblad have agreed to drop all claims against the institute in La Jolla, California, according to a joint statement released. [Nature News] Editorial Embattled French Health-Agency Chief Withdraws Leadership Bid The chief of France’s national biomedical-research agency INSERM has said that he will not run for a second term, a decision that ends months of uncertainty about his future at the organization. [Nature News] Editorial Australian Universities Condemn Romantic Supervisor-Student Relationships Academics should be removed from their supervisory, teaching or assessment roles if they develop a romantic relationship with one of their students, say organizations that represent Australian universities and students. [Nature News] Editorial
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EVENTSNEW Lorne Cancer Conference 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Positions – Breast Cancer Research (UPMC Hillman Cancer Center) Cancer Faculty Investigators – Cancer Research (University of Alabama at Birmingham) Postdoctoral Research Fellow – Immuno/Oncology of Breast Cancer (Henry M. Jackson Foundation) Research Assistant/Associate – Breast Cancer Therapeutics (King’s College London) Postdoctoral Training Fellow – Breast Cancer Research (Institute of Cancer Research) Postdoctoral Position – Breast Cancer (University of Trento) Postdoctoral Fellow – Molecular Mechanisms of Breast & Colon Cancers (Dalhousie University) Postdoctoral Research Associate – Breast Cancer (Howard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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