Mammary Cell News 10.48 December 6, 2018 | |
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TOP STORYResearchers showed that oncogenic HER2 tyrosine kinase signaling induced phosphorylation of mitochondrial creatine kinase 1 on tyrosine 153 in an ABL-dependent manner in breast cancer cells. [Cell Metab] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Targeting the BRD4/FOXO3a/CDK6 Axis Sensitizes AKT Inhibition in Luminal Breast Cancer Investigators showed that prolonged treatment of luminal breast cancer cells with AKT inhibitors induced FOXO3a dephosphorylation, nuclear translocation, and disrupted its association with SirT6, eventually leading to FOXO3a acetylation as well as BRD4 recognition. [Nat Commun] Full Article Exocyst Dynamics during Vesicle Tethering and Fusion Scientists discovered that mammalian exocyst was comprised of tetrameric subcomplexes that could associate independently with vesicles and plasma membrane and were in dynamic equilibrium with octamer and monomers. [Nat Commun] Full Article Investigators demonstrated that loss of dihydropyrimidinase-like-3 (DPYSL3) promoted cell-cycle arrest, multinucleation, and collapse of the vimentin microfilament network associated with increased phospho-vimentin. [Proc Natl Acad Sci USA] Full Article FSIP1 Regulates Autophagy in Breast Cancer Researchers showed that fibrous sheath interacting protein 1 (FSIP1) deficiency by shRNA-mediated knockdown or CRISPR-Cas9-mediated knockout significantly inhibited the proliferation and invasion of triple-negative breast cancer cells and impaired chemotherapy-induced growth inhibition in vivo. [Proc Natl Acad Sci USA] Full Article The upregulation of long noncoding RNA ATB (lncATB) in breast cancer cells was validated in a TGF-β-induced epithelial-mesenchymal transition model. Gain- and loss-of-function studies demonstrated that lncATB enhanced cell migration, invasion and clonogenicity in vitro and in vivo. [Cell Death Dis] Full Article LncRNA DANCR Upregulates PI3K/AKT Signaling through Activating Serine Phosphorylation of RXRA Scientists found that lncRNA DANCR was significantly overregulated in triple negative breast cancer (TNBC) tissues and cell lines compared with normal breast tissues or other type of breast cancer. Knockdown of DANCR suppressed TNBC proliferation both in vitro and in vivo. [Cell Death Dis] Full Article Investigators reported that treating endocrine therapy resistant cells with Tam or Fulvestrant increased H19 expression and that its decreased expression overcame resistance to Tam and Fulvestrant in these cells. [Cell Physiol Biochem] Full Article Ubiquitin-specific peptidase 37 (USP37) regulated the ability of cell invasion, epithelial-mesenchymal transition, stemness and cisplatin sensitivity in breast cancer cell lines. Additionally, USP37 knockdown inhibited tumorigenicity and increased anticancer effect of cisplatin in vivo. [J Exp Clin Cancer Res] Full Article Usp16 Modulates Wnt Signaling in Primary Tissues through Cdkn2a Regulation Scientists reported that Usp16, a negative regulator of Bmi1/PRC1 function, modulated the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential. [Sci Rep] Full Article Researchers demonstrated that plasmid DNA induced-extracellular vesicles laden with miR-335 efficiently and durably restored the endogenous miR-335 pool in human triple negative breast cancer cells, downregulated the expression of the miR-335 target gene SOX4 transcription factor, and markedly inhibited tumor growth in vivo. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSMolecular Mechanisms of Resistance to CDK4/6 Inhibitors in Breast Cancer: A Review The authors summarize the currently available knowledge regarding mechanisms of resistance to CDK4/6 inhibitors, and possible therapeutic strategies that may overcome this resistance as well. [Int J Cancer] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSNatera, Inc presented data from two studies this week demonstrating the ability of its Signateraâ„¢ research-use-only (RUO) circulating tumor DNA assay to detect molecular residual disease up to two years prior to clinical relapse and to predict treatment response in breast cancer. [Press release from Natera, Inc discussing research presented at the 2018 San Antonio Breast Cancer Symposium, San Antonio] Press Release Daiichi Sankyo Company, Limited announced updated efficacy and safety results from the ongoing Phase I/II study of U3-1402, an investigational and potential first-in-class HER3-targeting antibody drug conjugate, in 42 heavily pretreated patients with HER3-positive metastatic breast cancer. [Press release from Daiichi Sankyo Company, Limited discussing research presented at the 2018 San Antonio Breast Cancer Symposium, San Antonio] Press Release | |
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INDUSTRY NEWSNovartis AG announced additional analysis from the global Phase III SOLAR-1 trial investigating the alpha-specific PI3K inhibitor BYL719 in combination with fulvestrant in men and postmenopausal women with PIK3CA mutated hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2–) advanced or metastatic breast cancer. [Novartis AG] Press Release The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program announced plans to solicit and oversee research projects that evaluate cyclin dependent kinase (CDK)4 & 6 inhibitors in the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer and underlying mechanisms of resistance. [National Comprehensive Cancer Network] Press Release | |
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POLICY NEWSChina Backs Bold Plan to Tear Down Journal Paywalls In a huge boost to the open-access movement, librarians and funders in China have said that they intend to make results of publicly funded research free to read immediately on publication. The move includes a pledge of support for Plan S, a bold initiative launched in September by a group of European funders to ensure that, by 2020, their scientists make papers immediately open. [Nature News] Editorial Government Loyalist Appointed New UK Science Minister as Brexit Woes Continue Amid the carnage of Brexit, the UK government has gained a new science minister. Chris Skidmore was appointed on 5 December, succeeding Sam Gyimah, who resigned last week over the direction of Brexit negotiations. [Nature News] Editorial
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EVENTSNEW AACR Annual Meeting 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Assistant – Breast Medical Oncology (MD Anderson Cancer Center) NEW Associate Researcher – Breast Cancer Biology (Mount Sinai) NEW Senior Coordinator – Breast Medical Oncology (MD Anderson Cancer Center) NEW Research Fellow – Breast Cancer (International Iberian Nanotechnology Laboratory) NEW Master’s Student – Stem Cell Biology and Cancer (Helmholtz-Center München) Faculty Position – Cancer Cell Signaling (The University of New Mexico Comprehensive Cancer Center) Postdoctoral Research Associate – Cell Based Assays (University of Oxford) Postdoctoral Associate – Molecular and Cell Biology (Baylor College of Medicine) Faculty Position – Cancer Pathobiology (University of Alabama at Birmingham) Postdoctoral Position – Novel Cancer Gene and Therapy (University of Notre Dame) Postdoctoral Fellow – Stem Cells and Cancer (Albert Einstein College of Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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