Mammary Cell News 11.20 May 30, 2019 | |
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TOP STORYAtypical Function of a Centrosomal Module in WNT Signaling Drives Contextual Cancer Cell Motility Upon exosome mobilization of PCP-proteins, the authors showed that DVL2 orchestrated recruitment of a CEP192-PLK4/AURKB complex to the cell cortex where PLK4/AURKB act redundantly to drive protrusive activity and cell motility. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)SORLA Regulates Endosomal Trafficking and Oncogenic Fitness of HER2 Scientists found that sortilin-related receptor 1 (SORLA) co-precipitated with human epidermal growth factor receptor 2 (HER2) in cancer cells and regulated HER2 subcellular distribution by promoting recycling of the endosomal receptor back to the plasma membrane. [Nat Commun] Full Article Mitohormesis Primes Tumor Invasion and Metastasis Investigators showed that mitohormesis primed a subpopulation of cancer cells to basally upregulate mitochondrial stress responses, such as the mitochondrial unfolded protein response providing an adaptive metastatic advantage. [Cell Rep] Full Article | Graphical Abstract The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer Integrated genomic and immune landscapes showed that metastases propagated and evolved as communities of clones, revealed their predicted neo-antigen landscapes, and showed that they could accumulate HLA loss of heterozygosity. [Cell Rep] Full Article | Graphical Abstract Obesity-altered adipose stem cells (obASCs) were used to evaluate obesity-mediated effects of triple-negative breast cancer (TNBC). Both in vitro and in vivo analyses of TNBC cell lines were co-cultured with six pooled donors of obASCs or ASCs isolated from lean women. [Breast Cancer Res] Full Article Researchers compared the effects of down-regulated voltage-dependent anion channel 1 (VDAC1) expression in the U-87MG glioblastoma, MDA-MB-231 triple negative breast cancer and A549 lung cancer cell lines using si-RNA specific to human VDAC1. [Mol Ther Nucleic Acids] Abstract | Full Article Scientists investigated molecular mechanisms of BTG2/TIS21-inhibited Twist1 translation in triple negative breast cancer cells and in vivo BTG2/TIS21-knockout mice and human breast cancer tissues. [Cell Death Dis] Full Article Investigators showed that sntisense long noncoding mitochondrial RNA knockdown induced cell death preceded by proliferative blockage in three different human breast cancer cell lines. This effect is mediated by downregulation of the key cell cycle progression factors cyclin B1, cyclin D1, CDK1, CDK4, and survivin. [Cell Death Dis] Full Article Interleukin-32θ Inhibits Tumor-Promoting Effects of Macrophage-Secreted CCL18 in Breast Cancer In MDA-MB-231 cells, interleukin-32θ overexpression attenuated migration, invasion, tumor-promoting factors, and increased epithelial markers levels upon treatment with conditioned media from THP-1-derived macrophages. [Cell Commun Signal] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSEpigenetic Reprogramming of TGF-β Signaling in Breast Cancer The authors focus on recent advances relating to how epigenetic changes such as acetylation and methylation control the outcome of transforming growth factor-β (TGF-β) signaling and alter the fate of breast cancer cells. [Cancers] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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SCIENCE NEWSAthenex to Present at the 2019 ASCO Annual Meeting Athenex, Inc. announced that it will present data and exhibit at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting. [Press release from Athenex, Inc. discussing research to be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release Menarini Silicon Biosystems announced that two studies using the company’s CELLSEARCH® circulating tumor cell test provided preliminary insight into the impact of liquid biopsy on metastases and prognosis for patients with metastatic breast cancer. [Press release from Menarini Silicon Biosystems (PR Newswire Association LLC) discussing research to be presented at the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSSermonix Receives FDA Fast Track Designation for Investigational Drug Lasofoxifene Sermonix Pharmaceuticals LLC announced that its lead investigational drug, lasofoxifene, has been granted Fast Track designation by the FDA. Sermonix is currently engaged in a Phase II clinical study of lasofoxifene in estrogen receptor-positive metastatic breast cancer. [Sermonix Pharmaceuticals LLC] Press Release Novartis announced the FDA has approved Piqray® in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2–), PIK3CA-mutated, advanced or metastatic breast cancer, as detected by an FDA-approved test following progression on or after an endocrine-based regimen. [Novartis AG] Press Release | |
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POLICY NEWSHere’s Why the Outcomes of This Week’s European Elections Are Good News for Science Although populist and euroskeptic parties grew in last week’s elections for the European Parliament, the tsunami that EU supporters feared didn’t happen. That comes as a relief to many scientists, because several of the populist movements now on the rise in Europe appear to have little interest in science, flirt with antiscientific ideas, or have tried to curtail academic freedom. [ScienceInsider] Editorial White House Sends Mixed Messages on 2020 Research Spending Bills President Donald Trump doesn’t want Congress to boost the budgets of the National Institutes of Health or the National Science Foundation. But he has no objection to giving more research dollars to parts of the Department of Energy and NASA. [ScienceInsider] Editorial
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EVENTSNEW Cell Symposia: Hallmarks of Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Associate – Immune Responses (The Jackson Laboratory) Postdoctoral Fellows – Bioinformatics (IRCCS European Institute of Oncology) Postdoctoral Fellowship – PcG-Mediated Mechanisms in Breast Cancer (University of Miami) Postdoctoral Research Position – Molecular Biology & Cancer Research (Augusta University) Postdoctoral Fellowship – Tumor Suppressor CSMD1 (Lund University) Postdoctoral Position – Breast Cancer Research (Massachusetts General/Harvard Medical School) Faculty Position – Breast and Ovarian Cancer (Fred Hutchinson Cancer Research Center) Postdoctoral Associate – Cancer Immunology (The Jackson Laboratory) Postdoctoral Fellow – Cancer Bioinformatics (BC Cancer Research Center, PHSA) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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