Mammary Cell News Volume 11.23 | Jun 20 2019

TOP STORY

FOXF2 Reprograms Breast Cancer Cells into Bone Metastasis Seeds

Scientists showed that forkhead box F2 (FOXF2) functioned as a master transcription factor for reprogramming cancer cells into an osteomimetic phenotype by pleiotropic transactivation of the BMP4/SMAD1 signaling pathway and bone-related genes that are expressed at early stages of bone differentiation. [Nat Commun] Full Article

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Metabolic Adaptability in Metastatic Breast Cancer by AKR1B10-Dependent Balancing of Glycolysis and Fatty Acid Oxidation

AKR1B10^High tumor cells had reduced glycolytic capacity and dependency on glucose as fuel source but increased utilization of fatty acid oxidation. Conversely, in both 3D tumor spheroid assays and in vivo metastasis assays, inhibition of fatty acid oxidation blocked AKR1B10^High-enhanced metastatic colonization with no impact on AKR1B10^Low cells. [Nat Commun] Full Article

Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer

Researchers showed that estrogen-related receptor alpha (ERRα) inhibition interfered with pyruvate entry into mitochondria by inhibiting the expression of mitochondrial pyruvate carrier 1. This resulted in a dramatic increase in the reliance of cells on glutamine oxidation and the pentose phosphate pathway to maintain nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis. [Cell Rep] Full Article | Graphical Abstract

SOD1 Is Essential for Oncogene-Driven Mammary Tumor Formation but Dispensable for Normal Development and Proliferation

The authors showed that SOD1 was essential for oncogene-driven proliferation, but not normal proliferation of the mammary gland associated with pregnancy or other normal proliferative tissues such as skin and intestines. [Oncogene] Abstract

miR-665 Expression Predicts Poor Survival and Promotes Tumor Metastasis by Targeting NR4A3 in Breast Cancer

Investigators demonstrated that miR-665 promoted epithelial-mesenchymal transition, invasion and metastasis of breast cancer via inhibiting NR4A3 to activate the MAPK/ERK kinase signaling pathway. [Cell Death Dis] Full Article

CTDP1 Regulates Breast Cancer Survival and DNA Repair through BRCT-Specific Interactions with FANCI

Knockdown of C-terminal domain phosphatase 1 (CTDP1) increased MCF-10A sensitivity to DNA interstrand crosslinks and double-strand breaks, but not ultraviolet radiation. In addition, CTDP1 knockdown impaired in vitro and in vivo growth of breast cancer cell lines. [Cell Death Discov] Full Article

Somatic Loss of PIK₃R1 May Sensitize Breast Cancer to Inhibitors of the MAPK Pathway

Investigators created an isogenic cellular system by knocking out both alleles of the PI₃K regulatory subunit p85α (PIK₃R1) gene in the non-tumorigenic human breast cell line MCF-10A. Knockout cells were compared with wild-type cells by measuring growth, cellular signaling, and response to drugs. [Breast Cancer Res Treat] Abstract

PAR-4 Overcomes Chemo-Resistance in Breast Cancer Cells by Antagonizing cIAP1

Scientists demonstrated that loss of prostate apoptosis response-4 (PAR-4) in triple negative breast cancer cell lines mediated resistance to DNA damage-induced apoptosis and prevented activation of caspase-8. [Sci Rep] Full Article

Water Dynamics in MCF-7 Breast Cancer Cells: A Neutron Scattering Descriptive Study

Researchers provide the first step to untangle the role played by water dynamics in breast cancer cells after treatment with a chemotherapy drug. By thermal analyses, the cells were probed as micrometric reservoirs of bulk-like and confined water populations. [Sci Rep] Full Article | Press Release

Upregulation of Pluripotent Long Noncoding RNA ES3 in HER2‐Positive Breast Cancer

The authors found ES3 upregulation in breast cancer and its diagnostic value in breast cancer diagnosis. They revealed that the ES3 transcript had a high expression in high‐grade and high‐stage breast tumors. [J Cell Biochem] Abstract

Role of ALDH1A1 and HTRA2 Expression to CCL2/CCR2 Mediated Breast Cancer Cell Growth and Invasion

Using 3D Matrigel: Collagen cultures of SUM225 and DCIS.com breast cancer cells, researchers characterized the mechanisms of CCL2/CCR2 signaling in cell growth and invasion. [Biol Open] Abstract | Full Article

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HDL and LDL: Potential New Players in Breast Cancer Development

The authors review the progress to date in research on the potential role of the main cholesterol transporters, low-density and high-density lipoproteins (LDL and HDL), on breast cancer development. [J Clin Med] Full Article

Visit our reviews page to see a complete list of reviews in the mammary cell research field.

G1 Therapeutics Announces Updated Results from Phase II Trial of Trilaciclib in Combination with Chemotherapy Showed Statistically Significant Improvement in Overall Survival in Women with Metastatic Triple-Negative Breast Cancer

G1 Therapeutics, Inc. announced preliminary overall survival results from a randomized Phase II trial which demonstrated that women with metastatic triple-negative breast cancer lived significantly longer when receiving trilaciclib and chemotherapy compared with women receiving chemotherapy alone. [G1 Therapeutics, Inc.] Press Release

Garvan Researchers to Create an ‘Atlas’ for Breast Cancer

An ambitious project from the Garvan Institute of Medical Research will shine a spotlight on the complex molecular environment of breast cancers, providing unprecedented insights into the disease and, potentially, help develop better treatments. [Garvan Institute of Medical Research] Press Release

Dana-Farber Announces $20 Million Gift from the Saverin Family for Metastatic Breast Cancer Research

A $20 million gift announced from the Saverin Family will establish the Saverin Breast Cancer Research Fund at Dana-Farber Cancer Institute under the direction of Eric Winer, MD, Senior Vice President for Medical Affairs for Dana-Farber, Chief of the Division of Breast Oncology in the Susan F. Smith Center for Women’s Cancers at Dana-Farber, and the Thompson Chair in Breast Cancer Research at Dana-Farber. [Dana-Farber Cancer Institute] Press Release

Trump Issues Executive Order that Could Reduce Scientific Advice

President Donald Trump issued an executive order on June 14 to cut back the number of advisory committees by at least a third by the end of September, according to a statement from the White House. The federal advisory committee system is the formal structure for government agencies to seek advice from experts including scientists. [The Scientist] Editorial

China Clamps Down on Foreign Use of Chinese Genetic Material and Data

China has announced new regulations for the use of human genetic resources that come from Chinese participants. The rules, announced on June 10, require international scientists using biomaterials from China to have a Chinese collaborator and go into effect on July 1. [The Scientist] Editorial

Academics Join Outcry Sparked by Hong Kong’s Contentious Extradition Bill

Since the bill that would legalize the extradition of people from Hong Kong to mainland China to stand trial or serve criminal sentences was announced, more than a thousand academics from around the world have signed a petition against the proposed law, saying it would restrict free speech and academic debate as well as eroding personal freedoms. [Nature News] Editorial

NEW San Antonio Breast Cancer Symposium
December 10-14, 2019
San Antonio, Texas, United States

Visit our events page to see a complete list of events in the community.

NEW Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California)

Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin)

Canada Research Chair – Precision and Molecular Oncology (University of Calgary)

PhD Studentship – Molecular Mechanisms of Breast and Colorectal Cancers (Dalhousie University)

Postdoctoral Fellowship – Molecular Mechanisms of Breast and Colorectal Cancers (Dalhousie University)

Senior Global Medical Director – Breast Cancer (F.Hoffmann-La Roche)

Postdoctoral Fellow or Research Scientist – Cancer Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Associate – Immune Responses (The Jackson Laboratory)

Postdoctoral Fellows – Bioinformatics (IRCCS European Institute of Oncology)

Postdoctoral Fellowship – PcG-Mediated Mechanisms in Breast Cancer (University of Miami)

Postdoctoral Associate – Cancer Immunology (The Jackson Laboratory)

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