Mammary Cell News 11.40 October 17, 2019 | |
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TOP STORYInvestigators demonstrated that healthy human breast harbored a distinct γδ T cell compartment, primarily expressing T cell receptor Vδ1 chains, by comparison to Vδ2 chains that predominate in peripheral blood. Breast-resident Vδ1+ cells were functionally skewed toward cytolysis and IFN-γ production, but not IL-17, which has been linked with inflammatory pathologies. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)RORγ Is a Targetable Master Regulator of Cholesterol Biosynthesis in a Cancer Subtype Researchers showed that triple-negative breast cancer exhibited a hyper-activated cholesterol-biosynthesis program that was strongly linked to nuclear receptor RORγ, compared to estrogen receptor-positive breast cancer. Genetic and pharmacological inhibition of RORγ reduced tumor cholesterol content and synthesis rate while preserving host cholesterol homeostasis. [Nat Commun] Full Article The authors created a traceable MMTV-Wnt1-driven in vivo chimeric mammary tumor model comprising an admixture of low-Myc- and reversibly switchable high-Myc-expressing clones. They showed that such tumors exhibited interclonal mutualism wherein cells with high-Myc expression facilitated tumor growth by promoting protumorigenic stroma yet concomitantly suppress Wnt expression, which rendered them dependent for survival on paracrine Wnt provided by low-Myc-expressing clones. [Proc Natl Acad Sci USA] Full Article Although ablation of β1 or β3 integrin alone had limited effects on ErbB2-driven mammary tumorigenesis, deletion of both receptors resulted in a significant delay in tumor onset with a corresponding impairment in lung metastasis. Mechanistically, stiff extracellular matrix cooperated with integrin receptors to recruit insulin receptors (IRs) to focal adhesion through the formation of integrin/IR complexes, thereby preventing their lysosomal degradation. [Cell Rep] Full Article | Graphical Abstract Scientists showed that induction of miR-200c led to widespread alteration in long noncoding RNA (lncRNA) expression in breast cancer cells. They identified lncRNA LINC02582 as a target of miR-200c. [Cell Death Dis] Full Article As 3D cultures of tumor cells predicted efficacy of, and resistance to, a wide variety of cancer therapies, the authors employed tissue-engineering approaches to establish 3D pathomimetic avatars of human breast cancer cells alone and in the context of both their cellular and pathochemical microenvironments. [Cancer Metastasis Rev] Abstract To identify novel membrane proteins associated with migration and metastasis of breast cancer cells, scientists selected and characterized a more migrating subpopulation of MDA-MB-231 breast cancer cell line. They applied a high resolution quantitative mass spectrometry with SILAC labeling to analyze their surfaceome and compared it with that of parental MDA-MB-231 cells. [Proteomics] Abstract To effectively inhibit the growth of breast cancer cells by the combination method of chemotherapy and magnetic hyperthermia, researchers fabricated a biomimetic drug delivery system composed of mesoporous silica nanoparticles containing superparamagnetic ferroferric oxide and Paclitaxel coated with MDA-MB-231 cell membranes [Sci Rep] Full Article Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer GABRP gene knockdown inhibited triple negative breast cancer (TNBC) cell growth and colony formation in vitro and growth of MDA-MB-468 xenografts in nude mice. Commercially available anti-GABRP antibody or de novo generated Fabs inhibited TNBC cell growth in vitro. [Sci Rep] Full Article Four epithelial cancer cell lines representing the dominant cancers, namely a non-small-cell lung cancer cell line, two breast cancer cell lines, and a cervical cancer cell line were employed, and the mechanistic underpinning of MASM-induced apoptosis was investigated using flow cytometry, western blot and immunofluorescence. [BMC Cancer] Full Article Researchers investigated the mechanisms underlying LQB-223 anti-tumor effects in 2D and 3D models of breast cancer. MCF-7 and MDA-MB-231 cells had migration and motility profile assessed by wound-healing and phagokinetic track motility assays, respectively. [Int J Mol Sci] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSMicroRNAs and Epigenetics Strategies to Reverse Breast Cancer The authors illustrate how epigenetic instability orchestrates the attainment of cancer hallmarks which stimulate the neoplastic transformation-tumorigenesis-malignancy cascades. As reversibility of epigenetic controls is a promising feature to optimize for devising novel therapeutic approaches, they also focus on the strategies for restoring the epistate that favor improved disease outcome and therapeutic intervention. [Cells] Full Article Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSAtossa Genetics Receives IRB Approval for Phase II Breast Cancer Study Using Intraductal Technology Atossa Genetics Inc. and the Dr. Susan Love Research Foundation announced that the Institutional Review Board (IRB) has approved a Phase II clinical study of Atossa’s intraductal microcatheter technology for the administration of fulvestrant in patients with early-stage breast cancer or ductal carcinoma in situ. [Atossa Genetics Inc.] Press Release AstraZeneca and Daiichi Sankyo Company, Limited announced that the FDA has accepted for review the Biologics License Application for [fam-]trastuzumab deruxtecan and granted Priority Review. [AstraZeneca] Press Release | |
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POLICY NEWS$3 Billion Ballot Proposition Will Decide Fate of Texas Cancer Research Funding Agency On 5 November, Texas residents will decide whether to sustain CPRIT, the second largest public source of cancer funding in the United States after the federal government. At stake is its generous support for 123 tenure-track faculty like Cole, who investigates cancer and DNA repair. [ScienceMagazine] Editorial Indian Government Tightens Rules on Academic Collaboration with China India is tightening the rules for academic collaborations with its neighbor and main rival, China. Under a new policy, universities and research institutes must seek permission from the ministries of Home Affairs and External Affairs before signing a collaboration agreement or memorandum of understanding with a Chinese institution. [ScienceMagazine] Editorial German Lab Faces Criminal Charges after Undercover Investigation Charges have been lodged with a state prosecutor after the release of undercover video brought attention to the conditions under which animals are kept at the Laboratory of Pharmacology and Toxicology near Hamburg. [The Scientist] Editorial
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EVENTSNEW Translational Cancer Research for Basic Scientists Workshop Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Breast and Ovarian Cancer (Curtin University) Research Assistant – Breast and Endocrine Tumors (University of Texas MD Anderson Cancer Center) Chief Editor – Nature Ageing (Nature Research) Postdoctoral Position – Cancer Biology (Memorial Sloan Kettering Cancer Center) Research Scientist – Breast Cancer (The University of Pittsburgh) Postdoctoral Researcher – Nanomedicine and Immunoengineering (University of California San Diego) Project Scientist – Breast and Hematological Tumors (Cedars-Sinai) Postdoctoral Fellow – Breast and Prostate Cancer (Mayo Clinic Comprehensive Cancer Center) Postdoctoral Associate – Immune Responses (The Jackson Laboratory) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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