Mammary Cell News 12.06 February 20, 2020 | |
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TOP STORYEmbryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers The authors showed that intra-amniotic lentiviral injection could efficiently transduce progenitor cells of the adult mammary gland and used that as a platform to functionally screen over 500 genetic lesions for functional roles in tumor formation. [Cell Stem Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers found that moesin (MSN) significantly stimulated breast cancer cell proliferation and invasion in vitro and tumor growth in vivo, requiring the phosphorylation of MSN and a nucleoprotein NONO-assisted nuclear localization of phosphorylated MSN with protein kinase C (PKC) and then the phosphorylation activation of CREB signaling by PKC. [Sci Adv] Full Article Hsp47 Promotes Cancer Metastasis by Enhancing Collagen-Dependent Cancer Cell-Platelet Interaction The authors found that Hsp47-dependent collagen deposition and platelet recruitment facilitated cancer cell clustering and extravasation in vitro. By analyzing DNA/RNA sequencing data generated from human breast cancer tissues, they showed that gene amplification and increased expression of Hsp47 were associated with cancer metastasis. [Proc Natl Acad Sci USA] Full Article Ventral Prostate and Mammary Gland Phenotype in Mice with Complete Deletion of the ERβ Gene Overall the phenotype of the ventral prostate and mammary gland (MG) in ERβcrispr−/− mice was similar to, but more severe than, that in the ERβOS−/− mice. In the MG there was overexpression of estrogen receptor α and progesterone receptor, loss of collagen, increase in proliferation and expression of metalloproteases, and invasive epithelium. [Proc Natl Acad Sci USA] Full Article Mitogen-activated protein kinase (MAPK) inhibition altered p53 dynamics and p53-dependent gene expression after checkpoint enforcement, prolonging G2 arrest. In contrast, sustained MAPK signaling induced the phosphorylation of CDC25C, and consequently, the accumulation of pro-mitotic kinases, thereby relaxing checkpoint stringency and permitting cells to evade prolonged G2 arrest and senescence induction. [Cell Rep] Full Article | Graphical Abstract Researchers investigated the mechanisms of action (MOA) by which lipoic acid (LA) inhibited furin expression in estrogen receptor α (+) and (−) breast cancer cell lines. They unveiled that LA exerted a pro-oxidant effect on these cell lines; the resulting reactive oxygen species generated being responsible for the reduction in the expression of the major (CREB) protein [Oncogene] Abstract Scientists showed that Bcl-xL silencing led to migration defects in Hs578T and MDA-MB231 cells. These defects were rescued by re-expressing mitochondria-addressed, but not endoplasmic reticulum-addressed, Bcl-xL. [Oncogene] Abstract To investigate the functions of laminin-binding integrins, the authors obtained mutant mice with mammary luminal cell-specific deficiencies of the α3 and α6 integrin chains generated using the Cre-Lox approach. During pregnancy, mutant mice displayed decreased luminal progenitor activity and retarded lobulo-alveolar development. [Development] Abstract In MDA-MB-231 cells expressing exogenous 3xFLAG-tagged GLIS1, GLIS1 attenuated cell proliferation and enhanced cell mobility and invasion capacities under normoxia. In addition, breast cancer cells expressing GLIS1 acquired resistance to irradiation. [Carcinogenesis] Abstract MiR-136-5p suppression reversed the FAM83H-AS1 silencing-mediated inhibition of triple-negative breast cancer cell proliferation, migration, and invasion, suggesting that FAM83H-AS1 exerted its oncogenic effect by inhibiting miR-136-5p. [Aging (Albany NY)] Full Article Subscribe to one of our other 19 science newsletters such as Prostate Cell News & ESC & iPSC News. | |
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REVIEWSGap Junctions and Breast Cancer Dormancy Breast cancer relapse, despite clinical advancement, remains one of the biggest issues in the field. Intercellular communication, specifically via connexin-mediated gap junctions, play a key role in the long-term survival of these, treatment-resistant breast cancer stem cells, allowing for relapse. [Trends Cancer] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. | |
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INDUSTRY NEWSSELLAS Life Sciences Group, Inc. announced feedback from a Type C review with the FDA regarding its clinical development program for NPS in patients with TNBC. Based on written feedback from the FDA and on the totality of clinical, safety and translational NPS data presented to date, the company has finalized the design and plan for a Phase III registration-enabling study of NPS in combination with trastuzumab for the treatment of patients with TNBC in the adjuvant setting after standard treatment. [SELLAS Life Sciences Group, Inc.] Press Release Atreca, Inc. announced that the first patient has been dosed in a Phase Ib first-in-human clinical trial evaluating ATRC-101 in patients with select solid tumor cancers. [Atreca, Inc.] Press Release | |
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POLICY NEWSScholars Debate Causes of Women’s Underrepresentation in STEM Two new commentaries on a contested 2018 study about gender disparities in STEM fields clash over whether sex differences or social inequalities are to blame for the lack of women scientists and engineers. [The Scientist] Editorial The Next Chapter for African Genomics Nigeria is poised to become a hub for genetics research, but a few stubborn challenges block the way. [Nature News] Editorial
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EVENTSNEW The Evolving Landscape of Cancer Modeling Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Oncology (University of Miami Health System) Postdoctoral Research Position – Breast Cancer Research (The University of Texas) Postdoctoral Position – Breast Cancer Metastasis (University of Kentucky) Research Fellow – Breast Cancer (Dana-Farber Cancer Institute) Postdoctoral Fellow – Breast Tumorigenesis (University of Cincinnati) Postdoctoral Position – DNA Nanotechonology in Cancer (University of Duisburg-Essen) Postdoctoral Fellow – Clonal Evolution of Cancer (Moffitt Cancer Center & Research Institute) Investigator Position – Cancer Cell Biology (Winthrop P. Rockefeller Cancer Institute) Postdoctoral Research Fellow – Breast Cancer Research (University of South Carolina) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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