| Vol. 12.28 – 23 July, 2020 |
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| Scientists showed that LEFTY1, a secreted inhibitor of NODAL/SMAD2 signaling, was produced by mammary progenitor cells and, concomitantly, suppressed SMAD2 and SMAD5 signaling to promote long-term proliferation of normal and malignant mammary epithelial cells. [Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that both S-adenosylmethionine and 25-hydroxyvitamin D monotherapy reduced proliferation and clonogenic survival of a panel of breast cancer cell lines in vitro and inhibited tumor growth, lung metastasis, and breast tumor cell colonization to the skeleton in vivo. These effects were significantly more pronounced in the combination setting. [Bone Research] |
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| Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche. [Oncogene] |
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| The SUM Breast Cancer Cell Line Knowledge Base provides information on the derivation of each cell line, protocols for the proper maintenance of the cells, and a series of data mining tools that allow rapid identification of the oncogene signatures for each line. [NPJ Breast Cancer] |
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| Cyclophosphamide (CTX) increased expression of tumor cell PD-L1; however, when combined with concomitant PD-L1 antibody therapy none of the CTX regimens showed increased benefit. [NPJ Breast Cancer] |
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| Researchers found that non-structural maintenance of chromosome condensin 1 complex subunit G expression was highly upregulated in trastuzumab-resistant HER2+ breast cancer. [Cell Death & Disease] |
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| Investigators developed an in vitro 3D model comprising a central high-density mass of breast cancer cells surrounded by collagen type-1 and they incorporated fluid flow and pressure. [Scientific Reports] |
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| Scientists demonstrated a role for the extracellular matrix protein, nephronectin, in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. [Scientific Reports] |
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| The authors present current knowledge of the 5,6‐epoxycholesterols (5,6‐EC) metabolic pathway in breast cancer, focusing on the 5,6‐EC metabolic enzymes, ChEH and HSD11B2, and on 5,6‐EC metabolite targets, LXRβ and GR. [British Journal of Pharmacology] |
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| This perspective article highlights Slug functions in mammary epithelial cells and breast cancer as a “non-epithelial-mesenchymal transition factor” in basal epithelial cells and stem cells with focus reports that demonstrate co-expression of Slug and E-cadherin. [frontiers in Molecular Biosciences] |
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| Daiichi Sankyo Company, Ltd. and Gustave Roussy have announced a multi-year, multi-study research collaboration to enrich and further enable the development of DS-1062, and patritumab deruxtecan, two of Daiichi Sankyo’s lead DXd antibody drug conjugates, in lung and breast cancer. [Daiichi-Sankyo] |
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| For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic. [ScienceInsider] |
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| August 27 – August 29 Virtual |
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| University of Texas, Southwestern Medical Center – Dallas, Texas, United States |
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| Mayo Clinic – Rochester, Minnesota, United States |
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| Georgetown University Medical Center – Washington, District of Columbia, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Cedars-Sinai Medical School – Los Angeles, California, United States |
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