 | | Vol. 12.31 – 13 August, 2020 |
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| Investigators showed that breast cancer cells maintained in hypoxia release small extracellular vesicles that activated mitochondrial dynamics, stimulated mitochondrial movements, and promoted organelle accumulation at the cortical cytoskeleton in normal mammary epithelial cells.
[Developmental Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used metabolic tracer analysis to show that IκB kinase ε (IKKε) orchestrates a complex metabolic reprogramming that affected mitochondrial metabolism and consequently serine biosynthesis independently of its canonical signaling role.
[EMBO Reports] |
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| The authors showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis] |
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| Investigators found that by activating PRMT1, irradiation triggered a BRCA1-dependent program that resulted in efficient DNA repair and inhibition of apoptosis. Depletion of PRMT1 in irradiated cells resulted in a switch of BRCA1 functions from repair and survival in the nucleus to activation of cell death signals in the cytoplasm.
[Scientific Reports] |
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| Scientists tested three exosomes isolation methods and detergents for solubilization of exosomal proteins and enhanced detection by mass spectrometry.
[Scientific Reports] |
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| Several databases were employed to perform in silico analyses for glutathione peroxidases (GPXs) family genes. qRT-PCR, western blot and immunohistochemistry staining were introduced to validate GPX3 expression in breast cancer.
[Cancer Cell International] |
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| To better define the effects of oxidative stress, in vitro experiments were conducted on 4T1 and splenic mononuclear cells under hypoxic and normoxic conditions. Hydrogen peroxide was used as an reactive oxygen species source alone or in combination with hyaluronic acid.
[Journal of Cellular Physiology] |
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| The authors review the current knowledge of the oxytocin/oxytocin receptor (OTR) signaling system in healthy breast tissue as well as in breast cancer, and discuss OTR as a potential therapeutic target for breast cancer management.
[Oncogene] |
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| Roche announced that the Phase III IMpassion131 study, evaluating Tecentriq® in combination with paclitaxel, in comparison to placebo plus paclitaxel, did not meet statistical significance on its primary endpoint of progression-free survival for the initial treatment of people with metastatic triple-negative breast cancer, in the PD-L1-positive population.
[Roche] |
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| Provectus announced that the company has expanded its sponsored research program with Aru Narendran, MD, PhD, Professor, Departments of Pediatrics, Oncology, Biochemistry & Molecular Biology, and Physiology & Pharmacology at the Cumming School of Medicine of the University of Calgary in Calgary, Alberta, Canada.
[Provectus Biopharmaceuticals, Inc.] |
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| November 2 – November 3
Virtual |
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| | Myeloid Therapeutics – Cambridge, Massachusetts, United States |
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| | University of Miami Sylvester Comprehensive Cancer Center – Miami, Florida, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Mayo Clinic – Rochester, Minnesota, United States |
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| | University of Texas-Southwestern Medical Center – Dallas, Texas, United States |
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