| Vol. 12.37 – 24 September, 2020 |
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| In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promoted fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruited MRE11 and EXO1. [Molecular Cell] |
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| The authors present thermoresponsive, smart material microgels that can be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks. [Nature Communications] |
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| Scientists sought to understand the effects of CDK4/6 inhibition and radiation in multiple preclinical breast cancer models. [Clinical Cancer Research] |
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| The authors performed a dual-luciferase-based, genome-wide E3 ligase siRNA library screen and identified ASB13 as an E3 ubiquitin ligase that targeted SNAI2 for ubiquitination and degradation. [Genes & Development] |
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| Investigators demonstrated that RSK2 (p90 ribosomal S6 kinase 2) played a critical role in ER stress-induced autophagy in breast cancer cells. [Oncogene] |
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| The authors identified that the ubiquitin ligase RNF181 stabilized ERα and facilitated breast cancer progression. [Oncogene] |
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| Researchers report that Furin was frequently overexpressed in TNBC tumors and this correlated with poor prognosis in patients with TNBC tumors. [Cancers] |
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| Scientists tested the effectiveness of a novel class of 1,1-diarylethylene FOXM1 inhibitory compounds in suppressing TNBC cell migration, invasion, and metastasis using in vitro cell culture and in vivo tumor models. [Cancers] |
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| A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator. [Cell Proliferation] |
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| Investigators observed that high mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis. [Oncogenesis] |
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| The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses. [Diagnostics ] |
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| Eli Lilly and Company announced proof of concept data from an interim analysis of the BLAZE-1 clinical trial, showing a reduced rate of hospitalization for patients treated with LY-CoV555. [Eli Lilly and Company] |
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| November 11 – November 13 Virtual |
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| Cedars-Sinai Medical Center – Los Angeles, California, United States |
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| German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| Karlsruhe Institute of Technology – Karlsruhe, Germany |
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| University of Cincinnati – Cincinnati, Ohio, United States |
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| The Research Institute of the McGill University Health Centre – Montreal, Quebec, Canada |
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