Mammary Cell News Volume 12.37 | Sep 24 2020

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    2020-09-24 | MCN 12.37


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.37 – 24 September, 2020
    TOP STORY

    Lung
    Mesenchymal Cells Elicit Lipid Storage in Neutrophils That Fuel Breast Cancer Lung Metastasis

    In breast cancer models, scientists found that neutrophils were induced to accumulate neutral lipids upon interaction with resident mesenchymal cells in the premetastatic lung.
    [Nature Immunology]

    Abstract

    Live webinar by Dr. Ashley Watson on genome editing of stem and primary cell types.
    PUBLICATIONSRanked by the impact factor of the journal

    PCAF-Mediated
    Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

    Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promoted fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruited MRE11 and EXO1.
    [Molecular Cell]

    AbstractGraphical Abstract

    Mapping
    Cellular-Scale Internal Mechanics in 3D Tissues with Thermally Responsive Hydrogel Probes

    The authors present thermoresponsive, smart material microgels that can be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks.
    [Nature Communications]

    Full Article

    Short
    Term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor Positive Breast Cancers

    Scientists sought to understand the effects of CDK4/6 inhibition and radiation in multiple preclinical breast cancer models.
    [Clinical Cancer Research]

    Abstract

    ASB13
    Inhibits Breast Cancer Metastasis Through Promoting SNAI2 Degradation and Relieving Its Transcriptional Repression of YAP

    The authors performed a dual-luciferase-based, genome-wide E3 ligase siRNA library screen and identified ASB13 as an E3 ubiquitin ligase that targeted SNAI2 for ubiquitination and degradation.
    [Genes & Development]

    AbstractPress Release

    RSK2
    Protects Human Breast Cancer Cells Under Endoplasmic Reticulum Stress through Activating AMPKα2-Mediated Autophagy

    Investigators demonstrated that RSK2 (p90 ribosomal S6 kinase 2) played a critical role in ER stress-induced autophagy in breast cancer cells.
    [Oncogene]

    Abstract

    The Ubiquitin Ligase RNF181 Stabilizes ERα and Modulates Breast Cancer Progression

    The authors identified that the ubiquitin ligase RNF181 stabilized ERα and facilitated breast cancer progression.
    [Oncogene]

    Full Article

    Loss
    of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

    Researchers report that Furin was frequently overexpressed in TNBC tumors and this correlated with poor prognosis in patients with TNBC tumors.
    [Cancers]

    Full Article

    Suppression
    of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer

    Scientists tested the effectiveness of a novel class of 1,1-diarylethylene FOXM1 inhibitory compounds in suppressing TNBC cell migration, invasion, and metastasis using in vitro cell culture and in vivo tumor models.
    [Cancers]

    Full Article

    Transcriptional
    Repression of p21 by EIF1AX Promotes the Proliferation of Breast Cancer Cells

    A mechanistic investigation showed that EIF1AX inhibited the expression of p21, which is an essential cell cycle regulator.
    [Cell Proliferation]

    Full Article

    Tumor-Derived HMGB1 Induces CD62Ldim
    Neutrophil Polarization and Promotes Lung Metastasis in Triple-Negative Breast Cancer

    Investigators observed that high mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis.
    [Oncogenesis]

    Full Article


    Virtual Conference Exhibition: Organoids
    REVIEWS

    The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

    The cell-surface and subcellular biomarkers related to breast cancer stem cell (BCSC) phenotypes are increasingly being recognised. These biomarkers are useful for the isolation of BCSCs and can serve as potential therapeutic targets and prognostic tools to monitor treatment responses.
    [Diagnostics ]

    Full Article

    INDUSTRY AND POLICY NEWS

    Lilly
    Announces Proof of Concept Data for Neutralizing Antibody LY-CoV555 in the COVID-19 Outpatient Setting

    Eli Lilly and Company announced proof of concept data from an interim analysis of the BLAZE-1 clinical trial, showing a reduced rate of hospitalization for patients treated with LY-CoV555.
    [Eli Lilly and Company]

    Press Release

    FEATURED EVENT

    International Chemical Biology Society (ICBS) 2020 Conference

    November 11 – November 13
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Bioinformatics and Functional Genomics

    Cedars-Sinai Medical Center – Los Angeles, California, United States

    Postdoctoral Position – Breast Cancer

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Researcher – Breast Segmentation

    Karlsruhe Institute of Technology – Karlsruhe, Germany

    Postdoctoral Fellow – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

    Postdoctoral Fellow – Breast & Ovarian Cancer

    The Research Institute of the McGill University Health Centre – Montreal, Quebec, Canada

    > See All Jobs

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