Mammary Cell News Volume 12.38 | Oct 1 2020

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    2020-10-01 | MCN 12.38


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.38 – 1 October, 2020
    TOP STORY

    Upregulation of S100A10 in Metastasized Breast Cancer Stem Cells

    Knockdown of S100A10 in breast cancer cells suppressed their invasion abilities and overexpression of S100A10 in breast cancer patient‐derived tumor xenograft cells and 3D organoid formation capacities enhanced them in vitro.
    [Cancer Science]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Iodine Nanoparticle Radiotherapy of Human Breast Cancer Growing in the Brains of Athymic Mice

    Scientists used intravenously delivered iodine nanoparticles with human TNBC tumors growing in the brains of athymic nude mice.
    [Scientific Reports]

    Full Article

    Annurca Apple Polyphenol Extract Promotes Mesenchymal-to-Epithelial Transition and Inhibits Migration in Triple-Negative Breast Cancer Cells through ROS/JNK Signaling

    By qualitatively and quantitatively monitoring the real-time movements of live cells, researchers provided the first evidence that apple polyphenol extract inhibited the migration of MDA-MB-231 and MDA-MB-468 TNBC cells and downregulated metalloproteinase-2 and metalloproteinase-9.
    [Scientific Reports]

    Full Article

    Decorated Au NPs on Agar Modified Fe3O4 NPs: Investigation of Its Catalytic Performance in the Degradation of Methylene Orange, and Anti-Human Breast Carcinoma Properties

    The authors described an eco-friendly approach for in situ immobilization of Au nanoparticles on the surface of Fe3O4 nanoparticles, with help of Agar and ultrasound irradiations, without using any toxic reducing and capping agents.
    [International Journal of Biological Macromolecules]

    AbstractGraphical Abstract

    Recombinant Slam-Blind Measles Virus Is a Promising Candidate for Nectin-4-Positive Triple Negative Breast Cancer Therapy

    Scientists examined whether rMV-SLAMblind was effective for treating TNBC. Results suggested rMV-SLAMblind to be a promising candidate as a therapeutic agent for treating metastatic and/or TNBC.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    Introduction of Hsa-miR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

    Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
    [Breast Cancer Research and Treatment]

    Abstract

    Sodium Propionate Exerts Anticancer Effect in Mice Bearing Breast Cancer Cell Xenograft by Regulating JAK2/STAT3/ROS/p38 MAPK Signaling

    The authors investigated the effects of sodium propionate on the proliferation, apoptosis, autophagy, and antioxidant production of breast cancer cells.
    [Acta Pharmacologica Sinica]

    Full Article

    Knockdown of LINC00665 Inhibits Proliferation and Invasion of Breast Cancer via Competitive Binding of miR-3619-5p and Inhibition of Catenin Beta 1

    LINC00665 expression levels were determined using quantitative polymerase chain reaction analysis with breast cancer tissues and cell lines.
    [Cellular & Molecular Biology Letters]

    Full Article

    NDV-D90 Inhibits 17β-Estradiol-Mediated Resistance to Apoptosis by Differentially Modulating Classic and Nonclassic Estrogen Receptors in Breast Cancer Cells

    Scientists investigated whether Newcastle disease virus (NDV)‐D90, a novel strain isolated from natural sources in China, promoted apoptosis by modulating the expression of ERα or the G protein estrogen receptor in breast cancer cells exposed to 17β‐estradiol.
    [Journal of Cellular Biochemistry]

    Abstract

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    REVIEWS

    ARe We There Yet? Understanding Androgen Receptor Signaling in Breast Cancer

    As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling.
    [npj Breast Cancer]

    Full Article

    INDUSTRY AND POLICY NEWS

    Olema Oncology Raises $85 Million in Series C Financing to Advance Clinical Development of OP-1250 in Breast Cancer

    Olema Oncology announced the closing of a $85 million Series C financing. Olema used the financing proceeds to advance the clinical development of OP-1250, its lead product candidate in breast cancer, and expand ongoing research and development activities.
    [Olema Oncology]

    Press Release

    Cancer Compound Originating from the University of Illinois Scientists Leads to Major Licensing Deal

    Researchers affiliated with the Cancer Center at Illinois discovered a novel small molecule compound that is now the subject of a new global licensing agreement between the pharmaceutical company Bayer AG and the cancer drug development company, Systems Oncology LLC.
    [Cancer Center at Illinois]

    Press Release

    FEATURED EVENT

    10 Million Reasons to Defeat Cancer 2020 – Abbott World Summit

    October 13 – October 14
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Epigenomics in Breast and Prostate Cancer

    Princess Margaret Cancer Center – Toronto, Ontario, Canada

    Research Associate – Stem Cell Differentiation and Cancer Initiation

    University of Miami – Miami, Flordia, United States

    Postdoctoral Scientist – Bioinformatics and Functional Genomics

    Cedars-Sinai Medical Center – Los Angeles, California, United States

    Postdoctoral Position – Breast Cancer

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Researcher – Breast Segmentation

    Karlsruhe Institute of Technology – Karlsruhe, Germany

    > See All Jobs

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