Mammary Cell News Volume 12.45 | Nov 19 2020

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    2020-11-19 | MCN 12.45


    Mammary Cell News by STEMCELL Technologies
    Vol. 12.45 – 19 November, 2020
    TOP STORY

    Mechanical Suppression of Breast Cancer Cell Invasion and Paracrine Signaling to Osteoclasts Requires Nucleo-Cytoskeletal Connectivity

    Researchers examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration. Low-magnitude, high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration.
    [Bone Research]

    Full Article

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    Proto-Oncogene Src Links Lipogenesis via Lipin-1 to Breast Cancer Malignancy

    Scientists illustrated a direct lipogenesis-promoting role of the pro-oncogenic Src, providing a mechanistic link between obesity-associated mitogenic signaling and breast cancer malignancy.
    [Nature Communications]

    Full Article

    Proteomic Profiling and Genome-Wide Mapping of O-GlcNAc Chromatin-Associated Proteins Reveal an O-GlcNAc-Regulated Genotoxic Stress Response

    Comprehensive data was obtained by a chemical reporter-based method to survey O-GlcNAc function in human breast cancer cells stimulated with the genotoxic agent adriamycin.
    [Nature Communications]

    Full Article

    Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects

    To investigate the molecular effects of mutant estrogen receptor α (ER), researchers developed multiple isogenic ER mutant cell lines for the most common ligand binding domaid mutations, Y537S and D538G.
    [Cancer Research]

    Abstract

    ELP-Dependent Expression of MCL1 Promotes Resistance to EGFR Inhibition in Triple-Negative Breast Cancer Cells

    Using a genome-wide CRISPR-Cas9 genetic knockout screen, researchers found that the Elongator (ELP) complex mediated insensitivity to the EGFR inhibitor erlotinib in TNBC cells by promoting the synthesis of the antiapoptotic protein Mcl-1.
    [Science Signaling]

    Full Article

    Combination of Immunomagnetic Separation with Aptamer-Mediated Double Rolling Circle Amplification for Highly Sensitive Circulating Tumor Cell Detection

    Using human breast carcinoma BT474 cells as the model circulating tumor cell (CTC), a powerful assay platform was demonstrated by fluorescence spectrometry for the highly sensitive CTC detection by combining the dual-recognizing elements receptor-binding antibody and aptamer-mediated separation with double rolling circle amplification reactions
    [ACS Sensors]

    AbstractEditorialGraphical Abstract

    Tumor Necrosis Factor α Inhibition Overcomes Immunosuppressive M2b Macrophage-Induced Bevacizumab Resistance in Triple-Negative Breast Cancer

    Scientists developed a TNBC model resistant to bevacizumab under bevacizumab continuous administration. It was found that proportion of a specific subset of tumor-associated macrophages characterized as M2b increased and responsible for acquired resistance to bevacizumab.
    [Cell Death & Disease]

    Full Article

    In Vitro and In Vivo BNCT Investigations Using a Carborane Containing Sulfonamide Targeting CAIX Epitopes on Malignant Pleural Mesothelioma and Breast Cancer Cells

    Researchers merged the therapeutic effects associated with the inhibition of Carbonic Anhydrase IX (CAIX), an essential enzyme overexpressed by cancer cells including mesothelioma and breast cancer, with those ones brought by the application of Boron Neutron Capture Therapy (BNCT).
    [Scientific Reports]

    Full Article

    Evaluation of Chemotherapy and P2Et Extract Combination in Ex Vivo Derived Tumor Mammospheres from Breast Cancer Patients

    Investigators evaluated the presence of breast cancer stem cells as well as markers related to drug resistance in tumors obtained from 78 patients who had received (or not) chemotherapy before surgery.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Exosomes and Breast Cancer Drug Resistance

    The authors summarize the underlying associations between exosomes and drug resistance of breast cancer (BC) and discuss the unique biogenesis of exosomes, the change of exosome cargo, and the pattern of release by BC cells in response to drug treatment.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    Zymeworks and ALX Oncology Announce Clinical Collaboration Evaluating Zanidatamab with the CD47 Blocker ALX148 in Patients with Advanced HER2‑Expressing Breast Cancer

    Zymeworks, Inc. and ALX Oncology Holdings, Inc. announced they have entered into a clinical collaboration to evaluate the combination of Zymeworks’ zanidatamab, a HER2-targeted bispecific antibody, and ALX148, a next-generation CD47 blocker, for the treatment of patients with advanced HER2-expressing breast cancer and other solid tumors.
    [Zymeworks, Inc.]

    Press Release

    CHMP Recommends EU Approval of Roche’s Phesgo® (Fixed-Dose Combination of Perjeta and Herceptin for Subcutaneous Injection) for HER2-Positive Breast Cancer

    Roche announced that the European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Phesgo®, a fixed-dose combination of Perjeta® and Herceptin® with hyaluronidase, administered by subcutaneous injection in combination with intravenous chemotherapy, for the treatment of early and metastatic HER2-positive breast cancer.
    [Roche]

    Press Release

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    JOB OPPORTUNITIES

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