 | | Vol. 12.48 – 10 December, 2020 |
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| Scientists found that cultured circulating tumor cells, derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibited striking differences in proliferative potential in the brain.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated a novel mechanism for activation of GLI-mediated signaling in epithelial breast tumor cells via epithelial-to-mesenchymal transition (EMT) cell-induced production and secretion of VEGF-C.
[Oncogene] |
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| The authors optimized a small series of 4-acyl pyrroles, which they further analyzed by ITC, X-ray crystallography, selectivity studies, NCI60 cell-panel, and GI50 determinations for several cancer cell lines.
[Journal of Medicinal Chemistry] |
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| Investigators performed a genome-wide siRNA lethality screening and identified the RING-type E3 ubiquitin transferase (UBR2) as a specific regulator of caspase-independent cell death.
[Cell Death & Disease] |
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| Scientists explored the precise function of SPOCK1 in breast cancer progression and identified the mechanism by which SPOCK1 was involved in cell proliferation and epithelial-mesenchymal transition.
[Aging] |
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| In CCDC170-overexpressing MCF7 breast cancer cells, microarray analyses revealed that inositol-requiring enzyme 1 (IRE1) was the most elevated gene in enriched pathways.
[Aging] |
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| Combination therapy with small-molecule inhibitors of AKT and human epidermal growth factor receptor 2 (HER2) was conducted in HER2+ breast cancer cell lines with or without PIK3CA mutations, which led to constitutive activation of the PI3K pathway.
[Scientific Reports] |
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| Investigators revealed that apico-basal polarity of mammary epithelial cells occurred within a narrow range of matrix stiffness, and that phenotypic homogeneity was favored in matrices which were insensitive to MMP-mediated degradation.
[Scientific Reports] |
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| An orthotopic breast cancer mouse model was used to investigate the role of GREM1 in lung metastasis of breast cancer cells. GREM1 knockdown suppressed the proliferation of breast cancer cells, while its overexpression increased their growth, migration, and invasion.
[International Journal of Molecular Sciences] |
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| Research is underway to identify blood-based extracellular vesicle-associated diagnostic and predictive biomarkers for breast cancer.
[Drug Discovery Today] |
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| Odonate Therapeutics, Inc. announced the initiation of Cohort 3 of CONTESSA TRIO, which will evaluate tesetaxel monotherapy in approximately 60 non-elderly patients with human epidermal growth factor receptor 2-negative metastatic breast cancer.
[Odonate Therapeutics, Inc.] |
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| MSN Laboratories Private Limited received FDA approval to market their generic versions of Toremifene 60mg tablets & Aminocaproic Acid 500mg tablet under the Novadoz label. Toremifene 60mg, an estrogen agonist/antagonist for the treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor-positive or unknown tumors.
[MSN Laboratories Private Limited (PR Newswire, LLC)] |
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| January 15 – 16, 2021
Virtual |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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