 | | Vol. 13.01 – 14 January, 2021 |
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| Investigators report a nanotherapeutic strategy to kill cancer stem cells in tumors using nanoparticles that were co-loaded with the differentiation-inducing agent, all-trans retinoic acid, and the chemotherapeutic drug, camptothecin.
[Nature Nanotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Focusing on the shift in microbial community composition in diseased breast compared to normal breast, the authors identified the presence of Bacteroides fragilis in cancerous breast.
[Cancer Discovery] |
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| Investigators explored the efficacy of neratinib in combination with inhibitors of downstream signaling in HER2+ cancers in vitro and in vivo.
[Clinical Cancer Research] |
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| Researchers synthesized a small molecule inhibitor that acted as a transition state mimetic to block acetyl-CoA synthetase 2 (ACSS2) activity in vitro and in vivo.
[Cancer Research] |
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| Investigators found that high expression of desmoglein2, a component of desmosome-mediated intercellular adhesion complexes, promoted tumor growth, increased the prevalence of circulating tumor cell clusters, and facilitated distant organ colonization.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The effect of knocking down hsa_circ_0005273 in breast cancer cell lines was evaluated by examinations of cell proliferation, migration, and cell cycle.
[Journal of Experimental & Clinical Cancer Research] |
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| The oncogenic role of TINCR was examined in vitro and in vivo in breast cancer. The interaction between TINCR, DNMT1, and miR-503-5p methylation was explored.
[Cell Death & Disease] |
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| Researchers showed that lidocaine affected the viability and migration of breast cancer cells by regulating transient receptor potential 7 (TRPM7).
[Cancers] |
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| The authors found that interfering with the expression of the receptor for the lactogenic hormone prolactin in breast cancer cells representative of the luminal and epithelial breast cancer subtypes resulted in a loss of their differentiation state, enriched for stem-like cell subpopulations, and increased their tumorigenic capacity in a subtype-specific manner.
[Oncogenesis] |
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| Researchers investigated the biological functions of circNOL10 and its potential molecular mechanisms in breast cancer.
[Journal of Biomedical Science] |
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| Scientists identified the methyltransferase-like 3/microRNA-221-3p/homeodomain-interacting protein kinase 2/Che-1 (METTL3/miR-221-3p/HIPK2/Che-1) axis as a novel signaling event that may be responsible for the resistance of breast cancer cells to adriamycin.
[Experimental and Molecular Medicine] |
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| Researchers investigated the mechanism of metastasis in highly metastatic melanoma and breast cancer cells, and the mechanism of inhibition of metastasis by rhosin.
[Biomedicines] |
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| Targeting specific integrins and integrin-binding proteins may provide new therapeutic approaches for breast cancer therapies. Scientists examine the current knowledge of integrins’ role in breast cancer.
[Oncogene] |
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| The authors summarize and focus on the recent discoveries of promising macromolecules and cell-based biomarkers for the diagnosis and prognosis of breast cancer and provide implications for therapeutic strategies.
[International Journal of Molecular Sciences] |
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| HiberCell, Inc. announced an agreement with Biodesix, Inc. to further the development of an enzyme-linked immunosorbent assay as a companion diagnostic in future registrational trials in breast cancer for Imprime PGG programs.
[HiberCell, Inc.] |
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| January 25 – 28, 2021
Virtual |
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| | The Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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| | Salk Institute of Biological Studies – La Jolla, California, United States |
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Cancer Stem Cell News
Cell Therapy News
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Intestinal Cell News
Mammary Cell News
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