Mammary Cell News Volume 13.06 | Feb 18 2021

May 12, 2022

2021-02-18 | MCN 13.06

Mammary Cell News by STEMCELL Technologies

Vol. 13.06 – 18 February, 2021

TOP STORY

Creatine-Mediated
Crosstalk between Adipocytes and Cancer Cells Regulates Obesity-Driven Breast Cancer

Researchers performed transcriptomic analysis of cancer cells and adjacent adipose tissue in a murine model of obesity-accelerated breast cancer and identified glycine amidinotransferase in adipocytes and Acsbg1 in cancer cells as required for obesity-driven tumor progression.
[Cell Metabolism]

Abstract Graphical Abstract

Request a free copy of the Growing Organoids from Stem Cells Wallchart

PUBLICATIONSRanked by the impact factor of the journal

YAP
and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer

Scientists showed that the receptor tyrosine kinase Met promoted YAP activity in basal-like breast cancer and found enhanced YAP activity within the cancer stem cell population.
[Cancer Research]

Abstract

Targeting Transcription of MCL-1 Sensitizes HER2-Amplified
Breast Cancers to HER2 Inhibitors

Investigators found dinaciclib suppressed myeloid cell leukemia 1 (MCL-1) RNA and was highly effective at sensitizing human epidermal growth factor receptor 2 (HER2) inhibitors both in vitro and in vivo.
[Cell Death & Disease]

Abstract

Identification
of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition

The authors identified multiple cyclooxygenase 2 (COX-2) associated genes that regulate tumor lung colonization in TNBC. They found that silencing MFGE8 and KLK5/7 gene expression in TNBC cells markedly restored sensitivity to COX-2 selective inhibitor both in vitro and in vivo.
[Breast Cancer Research]

Full Article

GABARAP Suppresses EMT and Breast Cancer Progression via the AKT/mTOR Signaling Pathway

Researchers found that γ-aminobutyric acid type A (GABA_A) receptor-associated protein (GABARAP) inhibited proliferation, migration and invasion in vitro and in vivo.
[Aging]

Full Article

Arsenic
Hexoxide Has Differential Effects on Cell Proliferation and Genome-Wide Gene Expression in Human Primary Mammary Epithelial and MCF7 Cells

Scientists report the mechanisms of arsenic hexoxide (AS6) through transcriptome analyses. The cytotoxicity and global gene expression regulation by AS6 were compared in human normal and cancer breast epithelial cells.
[Scientific Reports]

Full Article

Phosphorylation
of the Proline-Rich Domain of WAVE3 Drives Its Oncogenic Activity in Breast Cancer

Researchers showed that phosphorylation of WAVE3 proline rich domain was essential for migration and invasion of breast cancer cells in vitro, as well as tumor growth and metastasis in vivo.
[Scientific Reports]

Full Article

Glucose-Limiting
Conditions Induce an Invasive Population of MDA-MB-231 Breast Cancer Cells with Increased Connexin 43 Expression and Membrane Localization

To better explore the effects of altered cellular metabolism on gap junctional intercellular communication in breast cancer, investigators generated a derivative of the TNBC cell line MDA-MB-231 optimized for growth in low-glucose.
[Journal of Cell Communication and Signaling]

Full Article

SNHG3
Promotes Migration, Invasion, and Epithelial-Mesenchymal Transition of Breast Cancer Cells through the miR-186-5p/ZEB1 Axis

Researchers demonstrated that the expression of small nucleolar RNA host gene 3 (SNHG3) was abnormally high in breast cancer tissues and cells, and transgenic expression of SNHG3 promoted the proliferation, migration, and invasion of breast cancer cell lines.
[American Journal of Translational Research]

Full Article

Scientific resources to support your cancer research. Learn More!

REVIEWS

SOX
Factors as Cell-State Regulators in the Mammary Gland and Breast Cancer

The authors review the molecular and functional evidence linking SOX factors with mammary gland development and discuss how these cell-fate regulators are co-opted in breast cancer.
[Seminars in Cell & Developmental Biology]

Abstract

Targeting
the Purinergic Pathway in Breast Cancer and Its Therapeutic Applications

Several purinergic pathways have been found to be involved in breast cancer cell survival and progression. In addition to analyzing the pathways involved, scientists review the therapeutic interventions already studied for breast cancer related to the purinergic system, as well as to other possible therapeutic targets.
[Purinergic Signalling]

Full Article

INDUSTRY AND POLICY NEWS

European Commission Approves Seagen’s TUKYSA^® (tucatinib) for the Treatment of Patients with Locally Advanced or Metastatic HER2-Positive Breast Cancer

Seagen, Inc. announced that the European Commission has granted marketing authorization for tucatinib in combination with trastuzumab and capecitabine for the treatment of adult patients with HER2-positive locally advanced or metastatic breast cancer who have received at least two prior anti-HER2 treatment regimens.
[Seagen, Inc.]

Press Release

FEATURED EVENT

Creatine-Mediated
Crosstalk between Adipocytes and Cancer Cells Regulates Obesity-Driven Breast Cancer

YAP
and β-Catenin Cooperate to Drive Oncogenesis in Basal Breast Cancer

Targeting Transcription of MCL-1 Sensitizes HER2-Amplified
Breast Cancers to HER2 Inhibitors

Identification
of MFGE8 and KLK5/7 as Mediators of Breast Tumorigenesis and Resistance to COX-2 Inhibition

GABARAP Suppresses EMT and Breast Cancer Progression via the AKT/mTOR Signaling Pathway

Arsenic
Hexoxide Has Differential Effects on Cell Proliferation and Genome-Wide Gene Expression in Human Primary Mammary Epithelial and MCF7 Cells

Phosphorylation
of the Proline-Rich Domain of WAVE3 Drives Its Oncogenic Activity in Breast Cancer

Glucose-Limiting
Conditions Induce an Invasive Population of MDA-MB-231 Breast Cancer Cells with Increased Connexin 43 Expression and Membrane Localization

SNHG3
Promotes Migration, Invasion, and Epithelial-Mesenchymal Transition of Breast Cancer Cells through the miR-186-5p/ZEB1 Axis

SOX
Factors as Cell-State Regulators in the Mammary Gland and Breast Cancer

Targeting
the Purinergic Pathway in Breast Cancer and Its Therapeutic Applications

European Commission Approves Seagen’s TUKYSA^® (tucatinib) for the Treatment of Patients with Locally Advanced or Metastatic HER2-Positive Breast Cancer

ISSCR:
Stem Cells – From Basic Science to Clinical Translation

> See All Events

Research
Scientist – Breast Oncology

Postdoctoral
Position – Breast Cancer

Postdoctoral
Associate – Breast Tumorigenesis

Academic
Surgical Pathologist – Breast Pathology

Postdoctoral
Researcher – Somatic Mutations in Ribosomal Proteins in Cancer

> See All Jobs