Mammary Cell News Volume 13.08 | Mar 4 2021

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    2021-03-04 | MCN 13.08


    Mammary Cell News by STEMCELL Technologies
    Vol. 13.08 – 4 March, 2021
    TOP STORY

    Oncogenic Translation Directs Spliceosome Dynamics Revealing an Integral Role for SF3A3 in Breast Cancer

    The authors revealed that SF3A3 protein levels predict molecular and phenotypic features of aggressive human breast cancers.
    [Molecular Cell]

    Full ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    TAp73 Represses NF-κB–Mediated Recruitment of Tumor-Associated Macrophages in Breast Cancer

    Scientists report that low levels of TAp73 correlated with an increased NF-κB–regulated inflammatory signature in breast cancer.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Tektin4 Loss Promotes Triple-Negative Breast Cancer Metastasis through HDAC6-Mediated Tubulin Deacetylation and Increases Sensitivity to HDAC6 Inhibitor

    The authors found that tektin4 loss sensitized triple-negative breast cancer cells, xenograft models, and patient-derived organoid models to the HDAC6-selective inhibitor ACY1215.
    [Oncogene]

    Abstract

    BCDIN3D RNA Methyltransferase Stimulates Aldolase C Expression and Glycolysis through Let-7 MicroRNA in Breast Cancer Cells

    In order to uncover metabolic pathways regulated by BCDIN3D in cancer, researchers performed an unbiased analysis of the metabolome, transcriptome, and proteome of breast cancer cells depleted for BCDIN3D.
    [Oncogene]

    Abstract

    Inhibiting β-Catenin Disables Nucleolar Functions in Triple-Negative Breast Cancer

    Investigators demonstrated that LAS1 like ribosome biogenesis factor protein expression was significantly elevated in TNBC patients, and it functionally was important for mammary tumor growth in xenograft models and enabled invasive attributes.
    [Cell Death & Disease]

    Full Article

    TGFβ/Cyclin D1/Smad-Mediated Inhibition of BMP4 Promotes Breast Cancer Stem Cell Self-Renewal Activity

    Scientists investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in TNBC. They found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low cancer stem cell population.
    [Oncogenesis]

    Full Article

    Involvement of Actin Cytoskeletal Modifications in the Inhibition of Triple Negative Breast Cancer Growth and Metastasis by Nimbolide

    Nimbolide inhibited cell proliferation, migratory, and invasive abilities of TNBC cells and also changed the shape of MDA-MB-231 cells, which is correlated with cytoskeletal changes including actin depolymerization.
    [Molecular Therapy-Oncolytics]

    AbstractFull ArticleGraphical Abstract

    The Long Noncoding RNA TINCR Promotes Breast Cancer Cell Proliferation and Migration by Regulating OAS1

    Researchers focused on terminal differentiation-induced non-coding RNA (TINCR) and explored its role in the pathogenesis of breast cancer.
    [Cell Death Discovery]

    Full Article

    BKM120 Sensitizes BRCA-Proficient Triple Negative Breast Cancer Cells to Olaparib through Regulating FOXM1 and Exo1 Expression

    Scientists found that dual phosphoinositide 3-kinase and poly ADP-ribose polymerase inhibition with BKM120 and olaparib significantly reduced the proliferation of BRCA-proficient TNBC cell lines.
    [Scientific Reports]

    Full Article

    Epithelial to Mesenchymal Transition and MicroRNA Expression Are Associated with Spindle and Apocrine Cell Morphology in Triple-Negative Breast Cancer

    The authors analyzed miRNA expression within areas of TNBCs with cellular morphology that may be related to the epithelial to mesenchymal transition process and discussed possible associations.
    [Scientific Reports]

    Full Article

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    REVIEWS

    The Onco-Immunological Implications of F. nucleatum in Breast Cancer

    Scientists discuss the breast tumor microbiota, its colonization by F. nucleatum, possible mechanisms by which F. nucleatum might promote breast cancer progression and how this might impact breast cancer treatment.
    [Immunology Letters]

    Abstract

    INDUSTRY AND POLICY NEWS

    Allarity Therapeutics Initiates Phase II Trial of IXEMPRA® in Europe for the Treatment of Metastatic Breast Cancer

    Allarity Therapeutics A/S announced that it has enrolled the first patient in its European Phase II clinical trial of IXEMPRA® for the treatment of metastatic breast cancer.
    [Allarity Therapeutics A/S]

    Press Release

    Kintara Therapeutics Appoints Dr. Mario Lacouture to Scientific Advisory Board for Cutaneous Metastatic Breast Cancer

    Kintara Therapeutics, Inc.announced the appointment of Mario Lacouture, to the REM-001 Scientific Advisory Board with the initial focus in Cutaneous Metastatic Breast Cancer.
    [Kintara Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics

    May 3 – 4, 2021
    Virtual

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    JOB OPPORTUNITIES

    Business Unit Head – Breast Cancer

    Gilead Sciences, Inc. – Zug, Switzerland

    Research Fellow – Breast Cancer Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Scientific Officer – Signaling & Cancer Metabolism Team

    Institute of Cancer Research – London, England, United Kingdom

    PhD Student – Metastatic Breast Cancer

    German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany

    Senior Scientist – Assay Development

    CyberCoders – San Diego, California, United States

    > See All Jobs

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