 | | Vol. 13.14 – 15 April, 2021 |
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| Researchers report that loss of exchange factor for ARF6, B (EFA6B) triggered a transcriptional reprogramming of cell-to-extracellular matrix interaction machinery and unleashed CDC42-dependent collective invasion in collagen.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors elucidated the cellular basis of tumor progression during the specification of the basal breast cancer subtype from the luminal progenitor population in the mouse mammary tumor virus-polyoma middle tumor-antigen mammary tumor model.
[Cell Reports] |
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| Researchers found an inverse correlation of IQGAP2 expression levels with oncogenic properties of breast cancer cell lines in estrogen receptor (ER) independent manner.
[Cell Death & Disease] |
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| Scientists report a novel function of nuclear ErbB2 in repressing the transcription of DEPTOR, a direct inhibitor of mammalian target of rapamycin.
[Cell Death & Disease] |
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| Scientists showed that the differences in progesterone receptor A (PRA) and PRB structure facilitated the binding of common and distinct protein interacting partners affecting the downstream signaling events of each PR-isoform. Tet-inducible HA-tagged PRA or HA-tagged PRB constructs were expressed in T47DC42 (PR/ER negative) breast cancer cells.
[Scientific Data] |
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| Investigators showed that the expression of basal/myoepithelial proteins CK5, CK14, and α-SMA altered along with the increasing grade of malignancy, and their loss affected the maintenance of organotypic 3D mammary architecture.
[iScience] |
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| Scientists report that TWIST1, an epithelial-to-mesenchymal transition (EMT) regulated by transcription factors, exhibited positive transcriptional regulation on PDGFRβ promoter, thus identifying PDGFRβ as one of the downstream targets of EMT regulation in breast cancer stem cells.
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] |
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| Investigators explored human TNBC metabolism by isotope tracing with glucose, a tracer that differentiates glycolytic versus oxidative pentose phosphate pathway catabolism and reveals glucose-driven anabolism.
[Med] |
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| The authors applied the pipeline to a breast cancer model and found that the L1PA2 transposon subfamily contributed abundant regulatory sequences to coordinated transcriptional regulation in breast cancer.
[Scientific Reports] |
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| Scientists explored the effect of combining metformin and propranolol, two repositioned drugs, in colorectal cancer and TNBC tumor types.
[Scientific Reports] |
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| The authors discuss the role of epithelial‐mesenchymal transition of breast cancer stem cells (BCSCs) in the setting of trastuzumab resistance and approaches of reducing or eradicating BCSCs in HER2‐positive breast cancer.
[Stem Cells] |
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| Investigators focus on the role of NLRP3 inflammasome and its components in breast cancer signaling, highlighting that a more detailed understanding of the clinical relevance of these pathways could significantly contribute to the development of novel therapeutic strategies for breast cancer.
[Journal of Biomedical Science] |
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| Everest Medicines announced that the FDA has granted full approval of Trodelvy® to Gilead Sciences, Inc, for the treatment of adult patients with unresectable locally advanced or metastatic TNBC who have received two or more prior systemic therapies, at least one of them for metastatic disease.
[Everest Medicines] |
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| Celcuity, Inc. reported preliminary data for the 103 patients enrolled in the expansion portion of an ongoing Phase Ib clinical trial evaluating gedatolisib, a first-in-class PI3K/mTOR inhibitor, plus Ibrance® and endocrine therapy, in ER+/HER2- advanced or metastatic breast cancer patients.
[Celcuity, Inc.] |
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| January 12 – 14, 2022
Shanghai, China |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | University of South Carolina – Columbia, South Carolina, United States |
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| | North Carolina Central University – Kannapolis, North Carolina, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | UT Southwestern Medical Center – Dallas, Texas, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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